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Biomedicines
Special Issues
Extracellular Vesicles in Drug Delivery System
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Extracellular Vesicles in Drug Delivery System

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 4724

Special Issue Editor

Dr. Hongbo Chen

E-Mail Website
Guest Editor
Associate Professor of Pharmacology, School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China
Interests: exosome; immunomodulatory drugs; cancer nanomedicine; exosomal-like nanovesicles; molecular cancer therapeutics

Special Issue Information

Dear Colleagues,

The special issue will focus on extracellular vesicles (EVs) -based drug delivery, including microvesicles, exosomes, ectosomes, apoptotic bodies, bacterial EVs plant EVs and milk EVs and so on. The focus areas of this topic include but are not limited to:

  • Progress in isolation and purification of extracellular vesicles.
  • Gene engineering and chemical modification of extracellular vesicles to improve their targeting or function.
  • Advances in dosage form, drug delivery routes and pharmacokinetics of extracellular vesicles.
  • Technical progress of exosomes loading small molecule drugs, protein and polypeptide drugs and nucleic acid drugs
  • Application of exosomes or drug loaded extracellular vesicles in tumor therapy, immunotherapy, tissue damage repair and other diseases.

Dr. Hongbo Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extracellular vesicles
  • drug delivery
  • EVs
  • exosomes
  • gene engineering

Published Papers (2 papers)

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Review

14 pages, 1522 KiB  
Review
Plant Exosome-like Nanovesicles and Their Role in the Innovative Delivery of RNA Therapeutics
by Yu-Xin Chen and Qiang Cai
Biomedicines 2023, 11(7), 1806; https://doi.org/10.3390/biomedicines11071806 - 24 Jun 2023
Cited by 1 | Viewed by 2137
Abstract
Exosomes are single membrane-bound spheres released from cells carrying complex cargoes, including lipids, proteins, and nucleic acids. Exosomes transfer specific cargoes from donor to acceptor cells, playing important roles in cell-to-cell communication. Current studies have reported that plant exosomes are prominent in transferring [...] Read more.
Exosomes are single membrane-bound spheres released from cells carrying complex cargoes, including lipids, proteins, and nucleic acids. Exosomes transfer specific cargoes from donor to acceptor cells, playing important roles in cell-to-cell communication. Current studies have reported that plant exosomes are prominent in transferring small RNA between host and pathogens in a cross-kingdom manner. Plant exosomes are excellent RNA interference (RNAi) delivery agents with similar physical and chemical properties to mammalian exosomes and have potential applications in therapeutic delivery systems. Recent data have suggested that plant exosome-like nanovesicles (PENVs) and artificial PENV-derived nano-vectors (APNVs) are beneficial for delivering therapeutic small RNA in mammalian systems and exhibit excellent competitiveness in future clinical applications. This review features their preparation methods, composition, roles in small RNA delivery for health functionalities, and their potency as functional nanomedicine. Full article
(This article belongs to the Special Issue Extracellular Vesicles in Drug Delivery System)
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17 pages, 1556 KiB  
Review
Novel Technologies for Exosome and Exosome-like Nanovesicle Procurement and Enhancement
by Andrés Martínez-Santillán and José González-Valdez
Biomedicines 2023, 11(5), 1487; https://doi.org/10.3390/biomedicines11051487 - 19 May 2023
Cited by 4 | Viewed by 2255
Abstract
Exosomes are extracellular nanovesicles commonly produced by mammalian cells that in recent years have risen as a novel strategy for drug delivery systems and cancer therapy because of their innate specificity and high bioavailability. However, there are limitations that undermine their potential. Among [...] Read more.
Exosomes are extracellular nanovesicles commonly produced by mammalian cells that in recent years have risen as a novel strategy for drug delivery systems and cancer therapy because of their innate specificity and high bioavailability. However, there are limitations that undermine their potential. Among them is the lack of mass production capacity with the current available sources and the failure to reach the intended therapeutic effect because of their insufficient uptake or their rapid clearance once administered. This review aims to show the current advances in overcoming these limitations by presenting, firstly, reported strategies to improve exosome and exosome-like nanovesicle extraction from possible novel eukaryotic sources, including animals, plants, and protozoa; and secondly, alternative modification methods that functionalize exosomes by conferring them higher targeting capacity and protection from organism defenses, which results in an increase in the attachment of ligands and cellular uptake of inorganic materials. However, even when these strategies might address some of the obstacles in their procurement and therapeutic use, there are still several aspects that need to be addressed, so several perspectives of the matter are also presented and analyzed throughout this work. Full article
(This article belongs to the Special Issue Extracellular Vesicles in Drug Delivery System)
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