The Role of Epithelial-Mesenchymal Transition (EMT) in Cancer Development and Metastasis
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 2514
Special Issue Editor
Special Issue Information
Dear Colleagues,
Benign tumor cells acquire infiltrating and metastasizing properties during tumor progression due to the epithelial to mesenchymal transition (EMT), which enhances tumors’ mobility, invasion, and resistance to apoptotic stimuli. EMT is known to generate cells with the properties of stem cells and according to a recent study carcinoma cells that have undergone an EMT differentiate into endothelial cells and contribute to tumor growth. Therefore, targeting EMT pathways constitutes an attractive strategy for cancer treatment. Major signaling pathways involved in EMT include transforming growth factor β(TGF-β), Wnt, Notch, Hedgehog, and other signaling pathways. These pathways are related to several transcription factors, including Twist, Smads and zinc finger proteins snail and slug. This Special Issue will focus on determining the functional role of EMT in metastasis, understanding the molecular mechanisms that regulate EMT-mediated tumor progression and metastasis, and the tools that are currently available for studying them both in vitro and in vivo (such as dynamic in vivo imaging, lineage tracing system, clinically relevant in vivo models, etc.).
Dr. Tapasree Roy Sarkar
Guest Editor
Manuscript Submission Information
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Keywords
- signaling networks guiding EMT
- EMT and metastasis
- in vivo models for studying EMT and metastasis
- EMT and tumor vasculature
- targeting EMT and cancer stem cells
- EMT in metastasis and therapy resistance
- cross-talk between EMT and autophagy
- miRNA-mediated EMT
- epigenetic regulation of EMT
