Advances in Macrophage-Based Immunotherapy

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1570

Special Issue Editor


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Guest Editor
1. Departamento de Medicina, Facultad de Medicina, Universidad de Valencia, 46010 Valencia, Spain
2. Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBERehd), 46010 Valencia, Spain
Interests: macrophages; fibrosis; TGF; WNT; myofibroblasts; MMT; NOTCH; complications; succinate; autophagy; senescence; chronic inflammation
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Special Issue Information

Dear Colleagues,

Adoptive cellular therapies are making major strides in the treatment of many diseases, especially in cancer and fibrosis. Amongst cell types used in immunotherapies, macrophages are prominent candidates. Macrophages have critical functions in both innate and adaptive immune responses. They are present in almost every tissue, recognize exogenous/endogenous danger signals through pattern-recognition receptors, produce cytokines/chemokines that orchestrate immune responses, function as professional antigen-presenting cells, and are important elements in wound repair and fibrosis by regulating extracellular matrix turnover. The diversity of functions they perform is due to the fact that their phenotype is highly plastic and exists across a spectrum of pro- and anti-inflammatory states. Plasticity allows participating in numerous effector functions that could support chronic autoimmune diseases, tumor, or fibrosis clearance. The Special Issue “Advanced in Macrophage-Based Immunotherapy” aims to collect information on the use of cell therapy in different pathologies, with a special interest in therapy that uses reprogrammed macrophages capable of limiting the pathology by modifying the microenvironment, favoring the cleaning of cancer and fibrotic cells or promoting regeneration, among other processes.

Prof. Dr. Dolores Ortiz-Masiá
Guest Editor

Manuscript Submission Information

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Keywords

  • macrophages
  • fibrosis
  • cancer
  • chronic inflammation
  • autophagy
  • apoptosis
  • senescence
  • immunotherapy

Published Papers (1 paper)

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Research

11 pages, 3214 KiB  
Article
Mechanisms Underlying the Suppression of IL-1β Expression by Magnesium Hydroxide Nanoparticles
by Ayaka Koga, Chuencheewit Thongsiri, Daisuke Kudo, Dao Nguyen Duy Phuong, Yoshihito Iwamoto, Wataru Fujii, Yoshie Nagai-Yoshioka, Ryota Yamasaki and Wataru Ariyoshi
Biomedicines 2023, 11(5), 1291; https://doi.org/10.3390/biomedicines11051291 - 27 Apr 2023
Viewed by 1256
Abstract
In recent years, magnesium hydroxide has been widely studied due to its bioactivity and biocompatibility. The bactericidal effects of magnesium hydroxide nanoparticles on oral bacteria have also been reported. Therefore, in this study, we investigated the biological effects of magnesium hydroxide nanoparticles on [...] Read more.
In recent years, magnesium hydroxide has been widely studied due to its bioactivity and biocompatibility. The bactericidal effects of magnesium hydroxide nanoparticles on oral bacteria have also been reported. Therefore, in this study, we investigated the biological effects of magnesium hydroxide nanoparticles on inflammatory responses induced by periodontopathic bacteria. Macrophage-like cells, namely J774.1 cells, were treated with LPS derived from Aggregatibacter actinomycetemcomitans and two different sizes of magnesium hydroxide nanoparticles (NM80/NM300) to evaluate their effects on the inflammatory response. Statistical analysis was performed using an unresponsive Student’s t-test or one-way ANOVA followed by Tukey’s post hoc test. NM80 and NM300 inhibited the expression and secretion of IL-1β induced by LPS. Furthermore, IL-1β inhibition by NM80 was dependent on the downregulation of PI3K/Akt-mediated NF-κB activation and the phosphorylation of MAPK molecules such as JNK, ERK1/2, and p38 MAPK. By contrast, only the deactivation of the ERK1/2-mediated signaling cascade is involved in IL-1β suppression by NM300. Although the molecular mechanism involved varied with size, these results suggest that magnesium hydroxide nanoparticles have an anti-inflammatory effect against the etiologic factors of periodontopathic bacteria. These properties of magnesium hydroxide nanoparticles can be applied to dental materials. Full article
(This article belongs to the Special Issue Advances in Macrophage-Based Immunotherapy)
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