Special Issue "Advances in Macrophage-Based Immunotherapy"
Deadline for manuscript submissions: 30 April 2024 | Viewed by 1084
2. Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBERehd), 46010 Valencia, Spain
Interests: macrophages; fibrosis; TGF; WNT; myofibroblasts; MMT; NOTCH; complications; succinate; autophagy; senescence; chronic inflammation
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Adoptive cellular therapies are making major strides in the treatment of many diseases, especially in cancer and fibrosis. Amongst cell types used in immunotherapies, macrophages are prominent candidates. Macrophages have critical functions in both innate and adaptive immune responses. They are present in almost every tissue, recognize exogenous/endogenous danger signals through pattern-recognition receptors, produce cytokines/chemokines that orchestrate immune responses, function as professional antigen-presenting cells, and are important elements in wound repair and fibrosis by regulating extracellular matrix turnover. The diversity of functions they perform is due to the fact that their phenotype is highly plastic and exists across a spectrum of pro- and anti-inflammatory states. Plasticity allows participating in numerous effector functions that could support chronic autoimmune diseases, tumor, or fibrosis clearance. The Special Issue “Advanced in Macrophage-Based Immunotherapy” aims to collect information on the use of cell therapy in different pathologies, with a special interest in therapy that uses reprogrammed macrophages capable of limiting the pathology by modifying the microenvironment, favoring the cleaning of cancer and fibrotic cells or promoting regeneration, among other processes.
Prof. Dr. Dolores Ortiz-Masiá
Manuscript Submission Information
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- chronic inflammation