Special Issue "Periodontal Inflammation, Periodontal Disease and Systemic Diseases"

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: 31 January 2024 | Viewed by 604

Special Issue Editor

Dr. Oelisoa Mireille Andriankaja
E-Mail Website
Guest Editor
Center for Oral Health Research (COHR), University of Kentucky College of Dentistry, Lexington, KY, USA
Interests: periodontal disease; periodontitis

Special Issue Information

Dear Colleagues,

Periodontal disease, which is a bacterial-induced infection that may lead to long-lasting oral inflammation, affects the soft connective tissue and supporting bone. The imbalance between periodontal pathogens and the immune and inflammatory responses of the host to the pathogens can explain chronic periodontal tissue destruction.

Besides the extensive studies of the relationships between periodontal disease, type 2 diabetes, and CVD, recent epidemiological studies have suggested an association between periodontal disease and many other systemic inflammatory diseases/disorders, including adverse pregnancy outcomes, rheumatoid arthritis, inflammatory bowel disease (IBD), Alzheimer’s disease, non-alcoholic fatty liver disease, certain cancers, and COVID-19. Most studies highlighted that periodontal disease as a risk factor for these systemic diseases/disorders, but few have assessed the reverse direction, i.e., that systemic diseases/disorders are risk factors for periodontal disease development or progression, while some authors suggested that a bi-directional relationship exists. Periodontal and systemic diseases may share underlying common biological pathways, the exacerbation of which may lead to the occurrence or co-occurrence of either or both health outcomes. These health conditions often occur in the same individuals, revealing a co-morbid condition, and they may act independently or adversely affect each other. However, the underlying mechanism pathways explaining the link between Periodontal disease and systemic comorbidities are still largely unknown. Understanding whether the link is simply a correlative one driven by causal mechanistic interactions is crucial to the diagnosis and treatment of these diseases.

For this Special Issue, we invite authors to submit articles focusing on the study of potential biological mechanisms related to the link between any systemic comorbid diseases/disorders and periodontal disease development. The topic also involve a mechanism of action driving the host-mediated tissue injury via its immune response to periodontal pathogens and related metabolic products and inflammation, which may interdependently play important roles in chronic periodontal tissue destruction.

Dr. Oelisoa Mireille Andriankaja
Guest Editor

Manuscript Submission Information

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  • periodontal disease
  • periodontitis
  • systemic diseases
  • biological mechanisms
  • correlation
  • inflammation
  • immune response
  • therapeutic targets

Published Papers (1 paper)

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15 pages, 720 KiB  
Periodontal Disease, Local and Systemic Inflammation in Puerto Ricans with Type 2 Diabetes Mellitus
Biomedicines 2023, 11(10), 2770; https://doi.org/10.3390/biomedicines11102770 - 12 Oct 2023
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Periodontal disease (PD) is prevalent in type 2 diabetic condition (T2DM). Objectives: We assessed the associations between serum or gingival crevicular fluid (GCF) endothelial and inflammatory mediators and chronic PD among T2DM Hispanic adults. Methods: We enrolled 248 Puerto Rican residents with T2DM [...] Read more.
Periodontal disease (PD) is prevalent in type 2 diabetic condition (T2DM). Objectives: We assessed the associations between serum or gingival crevicular fluid (GCF) endothelial and inflammatory mediators and chronic PD among T2DM Hispanic adults. Methods: We enrolled 248 Puerto Rican residents with T2DM aged 40–65 years. The exposures included serum inflammatory mediators (IL-1b, IL-6, IL-10, and TNF-α), endothelial adhesion molecules, RANKL levels, and the GCF content of these analytes from a subset of 158 samples. The outcomes included the percent of sites with a probing pocket depth (PPD) ≥ 4 mm and clinical attachment loss ≥ 4 mm. Adjusted logistic regression models were fit to the categorized outcomes. Results: Increased serum IL-10 (Adj. OR: 1.10, p = 0.04), sICAM-1 (Adj. OR: 1.01; p = 0.06), and elevated serum IL-1β (Adj. OR: 1.93; p = 0.06) were statistically significant or close to being significantly associated with a percent of sites with PPD ≥ 4 mm. An increase in GCF IL-1α (Adj. OR: 1.16; p < 0.01) and IL-1β (Adj: 2.40; p = 0.02) was associated with periodontal parameters. Conclusions: Our findings suggested that oral and systemic endothelial and inflammatory mediators are associated with periodontal clinical parameters among Hispanic adults with T2DM. Full article
(This article belongs to the Special Issue Periodontal Inflammation, Periodontal Disease and Systemic Diseases)
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