Dear Colleagues,

Periodontal disease, which is a bacterial-induced infection that may lead to long-lasting oral inflammation, affects the soft connective tissue and supporting bone. The imbalance between periodontal pathogens and the immune and inflammatory responses of the host to the pathogens can explain chronic periodontal tissue destruction.

Besides the extensive studies of the relationships between periodontal disease, type 2 diabetes, and CVD, recent epidemiological studies have suggested an association between periodontal disease and many other systemic inflammatory diseases/disorders, including adverse pregnancy outcomes, rheumatoid arthritis, inflammatory bowel disease (IBD), Alzheimer’s disease, non-alcoholic fatty liver disease, certain cancers, and COVID-19. Most studies highlighted that periodontal disease as a risk factor for these systemic diseases/disorders, but few have assessed the reverse direction, i.e., that systemic diseases/disorders are risk factors for periodontal disease development or progression, while some authors suggested that a bi-directional relationship exists. Periodontal and systemic diseases may share underlying common biological pathways, the exacerbation of which may lead to the occurrence or co-occurrence of either or both health outcomes. These health conditions often occur in the same individuals, revealing a co-morbid condition, and they may act independently or adversely affect each other. However, the underlying mechanism pathways explaining the link between Periodontal disease and systemic comorbidities are still largely unknown. Understanding whether the link is simply a correlative one driven by causal mechanistic interactions is crucial to the diagnosis and treatment of these diseases.

For this Special Issue, we invite authors to submit articles focusing on the study of potential biological mechanisms related to the link between any systemic comorbid diseases/disorders and periodontal disease development. The topic also involve a mechanism of action driving the host-mediated tissue injury via its immune response to periodontal pathogens and related metabolic products and inflammation, which may interdependently play important roles in chronic periodontal tissue destruction.

Dr. Oelisoa Mireille Andriankaja
Guest Editor

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• periodontal disease
• periodontitis
• systemic diseases
• biological mechanisms
• correlation
• inflammation
• immune response
• therapeutic targets