Novel Approaches towards Targeted Head and Neck Cancer Therapies

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1009

Special Issue Editor


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Guest Editor
Department of Biomedical and Clinical Sciences (BKV), Division of Cell Biology, Linköping University, Region Östergötland, 58185 Linköping, Sweden
Interests: head and neck cancer; cancer stem cells; biomarkers of treatment response; 3D tumor models; genetic and epigenetics of cancer cells; cancer metabolism EditInterests:

Special Issue Information

Dear Colleagues,

Head and neck cancer is often a highly malignant disease that is etiologically and genetically complex, and notoriously difficult to treat. Recent advances in our understanding of head and neck cancer biology have prompted us to compile this Special Issue. The research helping to uncover the unique properties of head and neck cancer has not only initiated the development of targeted therapies (therapies targeted at specific, upregulated signaling pathways and/or unique mutations frequently present in the particular cancer), such as EGFR-inhibitors and, to a certain extent, VEGF inhibitors, but has also helped to improve the efficacy of both classical chemotherapy protocols as well as radiotherapy. This Special Issue aims to gather manuscripts advancing our general knowledge of head and neck cancer biology, the development of novel therapies, as well as the communication on progress/improvement of classical therapies, including clinical trials.

Dr. Emilia Wiecheć
Guest Editor

Manuscript Submission Information

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Keywords

  • EGFR
  • VEGFR
  • RET
  • MET
  • PI3K
  • radiotherapy
  • chemotherapy
  • immunotherapy
  • HPV
  • preclinical HNSCC model
  • biomarkers of treatment response

Published Papers (1 paper)

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Research

14 pages, 1466 KiB  
Article
The Impact of Clinical Prognosis of Viral Hepatitis in Head and Neck Cancer Patients Receiving Concurrent Chemoradiotherapy
by Yu-Ming Wang, Sheng-Dean Luo, Ching-Nung Wu, Shao-Chun Wu, Wei-Chih Chen, Yao-Hsu Yang and Tai-Jan Chiu
Biomedicines 2023, 11(11), 2946; https://doi.org/10.3390/biomedicines11112946 - 01 Nov 2023
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Abstract
This study evaluated the clinical characteristics of head and neck cancer (HNC) patients with hepatitis B (HBV) or hepatitis C (HCV) who underwent concurrent chemoradiotherapy (CCRT) and examined the prognostic impact of antiviral therapies. In a 19-year retrospective analysis of 8224 HNC patients [...] Read more.
This study evaluated the clinical characteristics of head and neck cancer (HNC) patients with hepatitis B (HBV) or hepatitis C (HCV) who underwent concurrent chemoradiotherapy (CCRT) and examined the prognostic impact of antiviral therapies. In a 19-year retrospective analysis of 8224 HNC patients treated with CCRT, 29.8% (2452) were diagnosed with HBV or HCV, of whom 714 received antiviral therapy. For non-metastatic HNC patients on CCRT, factors such as gender, Charlson Comorbidity Index (CCI), liver cirrhosis markers (Fibrosis-4, APRI), and initial tumor stage were significant determinants of their overall survival. However, the presence of HBV or HCV and the administration of antiviral treatments did not yield distinct survival outcomes. In summary, antiviral therapy for HBV or HCV did not affect the 5-year survival rates of non-metastatic HNC patients undergoing CCRT, while gender, tumor stage, CCI, and liver cirrhosis were notable prognostic indicators. Full article
(This article belongs to the Special Issue Novel Approaches towards Targeted Head and Neck Cancer Therapies)
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