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Biomedicines
Special Issues
Animal Models for Neuropsychiatric Disorder Research
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Animal Models for Neuropsychiatric Disorder Research

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 1774

Special Issue Editors

Dr. Ioana-Miruna Balmus

E-Mail Website
Guest Editor
1. Department of Exact Sciences and Natural Sciences, Institute of Interdisciplinary Research, “Alexandru Ioan Cuza” University, Carol I Avenue, 20A, 700506 Iasi, Romania
2. Doctoral School of Biology, Faculty of Biology, “Alexandru Ioan Cuza” University, Carol I Avenue, 20A, 700506 Iasi, Romania
Interests: neurophysiology; neurodegeneration; animal behaviour; molecular biology; molecular genetics; oxidative stress
Dr. Alin Ciobica

E-Mail Website
Guest Editor
Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, B dul Carol I, No. 11, 700506 Iasi, Romania
Interests: neuropsychiatry; oxidative stress
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, “Animal Models for Neuropsychiatric Disorder Research”, will mainly focus on the importance of animal models in both basic and applied research, on the description of novel animal models, and innovative applications using the recognized models for neuropsychiatric disorders (NDs) research.

The topics addressed in this Special Issue include, but are not limited to:

  • Neurophysiopathological mechanisms of common and rare NDs;
  • Mechanistic and pharmacological aspects of neuropsychiatric comorbidities in chronic diseases and of disorders co-occurring with NDs;
  • The roles of oxidative stress and inflammation in NDs and comorbidities;
  • Extraneuronal manifestations of NDs;
  • Pharmacokinetic and neurophysiological descriptions of innovative animal models;
  • Biomedicines offering promising results in neuropsychiatric disorders’ treatment and management.

We invite authors to submit original research, presenting their innovative work in animal model research in NDs and good quality review articles dealing with various controversies in animal model research.

Dr. Ioana-Miruna Balmus
Dr. Alin Ciobica
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • animal models
  • neurodegeneration
  • aging
  • affective spectrum disorders
  • autism spectrum disoder
  • oxidative stress
  • inflammation
  • antioxidant biomedicines
  • anti-inflammatory biomedicines

Published Papers (1 paper)

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Research

20 pages, 3097 KiB  
Article
Abstinence from Escalation of Cocaine Intake Changes the microRNA Landscape in the Cortico-Accumbal Pathway
by Vidhya Kumaresan, Yolpanhchana Lim, Poorva Juneja, Allison E. Tipton, Giordano de Guglielmo, Lieselot L. G. Carrette, Marsida Kallupi, Lisa Maturin, Ying Liu, Olivier George and Huiping Zhang
Biomedicines 2023, 11(5), 1368; https://doi.org/10.3390/biomedicines11051368 - 05 May 2023
Cited by 1 | Viewed by 1477
Abstract
Cocaine administration alters the microRNA (miRNA) landscape in the cortico-accumbal pathway. These changes in miRNA can play a major role in the posttranscriptional regulation of gene expression during withdrawal. This study aimed to investigate the changes in microRNA expression in the cortico-accumbal pathway [...] Read more.
Cocaine administration alters the microRNA (miRNA) landscape in the cortico-accumbal pathway. These changes in miRNA can play a major role in the posttranscriptional regulation of gene expression during withdrawal. This study aimed to investigate the changes in microRNA expression in the cortico-accumbal pathway during acute withdrawal and protracted abstinence following escalated cocaine intake. Small RNA sequencing (sRNA-seq) was used to profile miRNA transcriptomic changes in the cortico-accumbal pathway [infralimbic- and prelimbic-prefrontal cortex (IL and PL) and nucleus accumbens (NAc)] of rats with extended access to cocaine self-administration followed by an 18-h withdrawal or a 4-week abstinence. An 18-h withdrawal led to differential expression (fold-change > 1.5 and p < 0.05) of 21 miRNAs in the IL, 18 miRNAs in the PL, and two miRNAs in the NAc. The mRNAs potentially targeted by these miRNAs were enriched in the following pathways: gap junctions, neurotrophin signaling, MAPK signaling, and cocaine addiction. Moreover, a 4-week abstinence led to differential expression (fold-change > 1.5 and p < 0.05) of 23 miRNAs in the IL, seven in the PL, and five miRNAs in the NAc. The mRNAs potentially targeted by these miRNAs were enriched in pathways including gap junctions, cocaine addiction, MAPK signaling, glutamatergic synapse, morphine addiction, and amphetamine addiction. Additionally, the expression levels of several miRNAs differentially expressed in either the IL or the NAc were significantly correlated with addiction behaviors. Our findings highlight the impact of acute and protracted abstinence from escalated cocaine intake on miRNA expression in the cortico-accumbal pathway, a key circuit in addiction, and suggest developing novel biomarkers and therapeutic approaches to prevent relapse by targeting abstinence-associated miRNAs and their regulated mRNAs. Full article
(This article belongs to the Special Issue Animal Models for Neuropsychiatric Disorder Research)
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