Dear Colleagues,

Immune cells fight against infections and sustain cell integrity and homeostasis by initiating and orchestrating finely tuned immune responses to manifold internal and external triggers, including pathogens and cytokines. Innate and adaptive immune responses are shaped by intricate signaling networks. In relation to this, the fascinating and rapidly evolving field of immunometabolism depicts the impact of metabolites, enzymes, and pathways on immune system plasticity in both quiescence and activation. During immune cell activation, metabolism becomes highly adaptable to promptly provide necessary materials according to the organism's requirements. Metabolic processes provide nutrients and energy and also contribute to gene expression reprogramming and transcription of multiple signal proteins. The metabolic and transcriptional profiles drive the development of various immune cell subsets. Indeed, metabolic signaling is closely related to epigenetic and, in turn, gene expression changes in both innate and adaptive immune cells. There is a large body of evidence on how aberrant immunometabolism contributes to immune dysfunction and diseases like cancer and chronic inflammatory disorders such as diabetes, obesity, atherosclerosis, and rheumatoid arthritis.

For our upcoming Special Issue, we invite researchers to contribute their valuable work, whether original research or review articles, on the most recent findings of signaling networks, including immunometabolic pathways and mechanisms of gene expression in immune cells. We further encourage contributions that delve into the regulation, mechanisms, pathways, gene expression reprogramming, cell types, and mediators involved in the interplay between immunity and metabolism, as well as emerging therapies.

Dr. Santarsiero Anna
Dr. Vittoria Infantino
Dr. Paolo Convertini
Guest Editors

Manuscript Submission Information

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• cell signaling
• immunometabolism
• metabolic reprogramming
• immunity
• innate immune cells
• adaptive immunity
• transcriptional/post-transcriptional regulation
• gene expression
• inflammatory process
• inflammatory diseases