Special Issue "Signaling Networks and Gene Expression in Immune Cells"

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 53

Special Issue Editors

Department of Science, University of Basilicata, Potenza, Italy
Interests: gene expression; transcriptional regulation; macrophage activation; immunometabolism
Department of Science, University of Basilicata, Potenza, Italy
Interests: macrophage activation; cell signaling; immunometabolism; gene expression; transcriptional regulation; mitochondria; epigenetic mechanisms
Special Issues, Collections and Topics in MDPI journals
Dr. Paolo Convertini
Guest Editor
Department of Science, University of Basilicata, Potenza, Italy
Interests: transcriptional regulation; post-transcriptional regulation; miRNA; splicing mechanisms; liver
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Immune cells fight against infections and sustain cell integrity and homeostasis by initiating and orchestrating finely tuned immune responses to manifold internal and external triggers, including pathogens and cytokines. Innate and adaptive immune responses are shaped by intricate signaling networks. In relation to this, the fascinating and rapidly evolving field of immunometabolism depicts the impact of metabolites, enzymes, and pathways on immune system plasticity in both quiescence and activation. During immune cell activation, metabolism becomes highly adaptable to promptly provide necessary materials according to the organism's requirements. Metabolic processes provide nutrients and energy and also contribute to gene expression reprogramming and transcription of multiple signal proteins. The metabolic and transcriptional profiles drive the development of various immune cell subsets. Indeed, metabolic signaling is closely related to epigenetic and, in turn, gene expression changes in both innate and adaptive immune cells. There is a large body of evidence on how aberrant immunometabolism contributes to immune dysfunction and diseases like cancer and chronic inflammatory disorders such as diabetes, obesity, atherosclerosis, and rheumatoid arthritis.

For our upcoming Special Issue, we invite researchers to contribute their valuable work, whether original research or review articles, on the most recent findings of signaling networks, including immunometabolic pathways and mechanisms of gene expression in immune cells. We further encourage contributions that delve into the regulation, mechanisms, pathways, gene expression reprogramming, cell types, and mediators involved in the interplay between immunity and metabolism, as well as emerging therapies.

Dr. Santarsiero Anna
Dr. Vittoria Infantino
Dr. Paolo Convertini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cell signaling
  • immunometabolism
  • metabolic reprogramming
  • immunity
  • innate immune cells
  • adaptive immunity
  • transcriptional/post-transcriptional regulation
  • gene expression
  • inflammatory process
  • inflammatory diseases

Published Papers

This special issue is now open for submission.
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