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Biomedicines
Special Issues
Future Trends in Regenerative Medicine
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Future Trends in Regenerative Medicine

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 5605

Special Issue Editor

Prof. Dr. Carlos Fernando Mourão

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Guest Editor
Department of Periodontology, Dental Research Administration, Tufts University School of Dental Medicine, Boston, MA 02111, USA
Interests: membranes/barries; blood-derived growth factors; guide bone regeneration; soft tissue regeneration; biomaterials; regenerative medicine; drug delivery systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Regenerative medicine is the field of medicine that focuses on repairing or replacing damaged tissues or organs by stimulating the body’s natural processes for healing and regrowth. Regenerative medicine uses medical techniques to accelerate and direct the body’s natural healing processes and promote tissue regeneration. This can help patients with serious illnesses or injuries to regain and maintain their health and quality of life. A branch of regenerative medicine, tissue engineering focuses on creating new tissues and organs in the laboratory. In recent years, many tissue engineering techniques have been developed and refined. These techniques are used to produce a wide variety of engineered tissues and organs (e.g., skin, bone, cartilage, and blood vessels). The present topic aims to report on the latest knowledge in the regenerative field, including hard and soft tissue regeneration, wound healing, and other technologies in tissue regeneration.

Prof. Dr. Carlos Fernando Mourão
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • new bone substitutes
  • membranes and/or barriers
  • stem cells
  • 3D bioprinting
  • growth factors
  • cell repair

Published Papers (3 papers)

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Research

12 pages, 4030 KiB  
Article
Plasma Gel Made of Platelet-Poor Plasma: In Vitro Verification as a Carrier of Polyphosphate
by Masayuki Nakamura, Hideo Masuki, Hideo Kawabata, Taisuke Watanabe, Takao Watanabe, Tetsuhiro Tsujino, Kazushige Isobe, Yutaka Kitamura, Carlos Fernando Mourão and Tomoyuki Kawase
Biomedicines 2023, 11(11), 2871; https://doi.org/10.3390/biomedicines11112871 - 24 Oct 2023
Cited by 1 | Viewed by 1381
Abstract
Plasma gel (PG) is a blood-derived biomaterial that can be prepared by heating or chemical cross-linking without the aid of intrinsic coagulation activity and has gradually been applied in the field of esthetic surgery. To explore the applicability of PG in regenerative therapy [...] Read more.
Plasma gel (PG) is a blood-derived biomaterial that can be prepared by heating or chemical cross-linking without the aid of intrinsic coagulation activity and has gradually been applied in the field of esthetic surgery. To explore the applicability of PG in regenerative therapy or tissue engineering, in this study, we focused on the advantages of the heating method and verified the retention capacity of the resulting PG for polyphosphate (polyP), a polyanion that contributes to hemostasis and bone regeneration. Pooled platelet-poor plasma (PPP) was prepared from four healthy male adult donors, mixed with synthetic polyP, and heated at 75 °C for 10 or 30 min to prepare PG in microtubes. The PG was incubated in PBS at 37 °C, and polyP levels in the extra-matrix PBS were determined by the fluorometric method every 24 h. The microstructure of PG was examined using scanning electron microscopy. In the small PG matrices, almost all of the added polyP (~100%) was released within the initial 24 h. In contrast, in the large PG matrices, approximately 50% of the polyP was released within the initial 24 h and thereafter gradually released over time. Owing to its simple chemical structure, linear polyP cannot be theoretically retained in the gel matrices used in this study. However, these findings suggest that thermally prepared PG matrices can be applied as carriers of polyP in tissue engineering and regenerative medicine. Full article
(This article belongs to the Special Issue Future Trends in Regenerative Medicine)
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12 pages, 1323 KiB  
Article
Efficacy of Fractional CO2 Laser Treatment for Genitourinary Syndrome of Menopause in Short-Term Evaluation—Preliminary Study
by Andrzej Woźniak, Sławomir Woźniak, Ewa Poleszak, Tomasz Kluz, Łukasz Zapała, Aleksander Woźniak, Tomasz Rechberger and Andrzej Wróbel
Biomedicines 2023, 11(5), 1304; https://doi.org/10.3390/biomedicines11051304 - 28 Apr 2023
Cited by 2 | Viewed by 1454
Abstract
The postmenopausal state covers 40% of modern women’s lives and 50–70% of postmenopausal women report GSM symptoms such as vaginal dryness, itching, frequent inflammations, lack of elasticity, or dyspareunia. Consequently, a safe and effective method of treatment is crucial. In a group of [...] Read more.
The postmenopausal state covers 40% of modern women’s lives and 50–70% of postmenopausal women report GSM symptoms such as vaginal dryness, itching, frequent inflammations, lack of elasticity, or dyspareunia. Consequently, a safe and effective method of treatment is crucial. In a group of 125 patients, a prospective observational study was performed. The aim was to evaluate the clinical effectiveness of fractional CO2 laser in the treatment of GSM symptoms using a protocol of three procedures in 6-week intervals. The vaginal pH, VHIS, VMI, FSFI, and treatment satisfaction questionnaire were used. The fractional CO2 laser treatment was effective in improving all the objective forms of evaluation: vaginal pH (from 5.61 ± 0.50 at the baseline up to 4.69 ± 0.21 in the 6-week follow-up after the third procedure); VHIS (12.02 ± 1.89 at the baseline vs. 21.50 ± 1.76); VMI (21.5 ± 5.66 vs. 48.4 ± 4.46). Similar results were obtained for FSFI: 12.79 ± 5.351 vs. 24.39 ± 2.733, where 79.77% of patients were highly satisfied. Fractional CO2 laser therapy increases the quality of life by having a beneficial effect on the sexual function of women with GSM symptoms. This effect is obtained by restoring the correct structure and proportions of the cellular composition of the vaginal epithelium. This positive effect was confirmed by both objective and subjective forms of evaluating GSM symptom severity. Full article
(This article belongs to the Special Issue Future Trends in Regenerative Medicine)
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16 pages, 4524 KiB  
Article
Morpho-Functional Effect of a New Collagen-Based Medical Device on Human Gingival Fibroblasts: An In Vitro Study
by Tea Romasco, Pier Michele Mandrillo, Erica Morsut, Margherita Tumedei, Domitilla Mandatori, Morena Petrini, Maria Cristina Curia, Francesco De Angelis, Camillo D’Arcangelo, Adriano Piattelli and Natalia Di Pietro
Biomedicines 2023, 11(3), 786; https://doi.org/10.3390/biomedicines11030786 - 5 Mar 2023
Cited by 1 | Viewed by 2314
Abstract
Maintaining periodontal and peri-implant soft tissues health is crucial for the long-term health of teeth and dental implants. New biomedical strategies aimed at avoiding connective tissue alterations and related diseases (e.g., periodontitis and peri-implantitis) are constantly evolving. Among these, collagen-based medical products have [...] Read more.
Maintaining periodontal and peri-implant soft tissues health is crucial for the long-term health of teeth and dental implants. New biomedical strategies aimed at avoiding connective tissue alterations and related diseases (e.g., periodontitis and peri-implantitis) are constantly evolving. Among these, collagen-based medical products have proven to be safe and effective. Accordingly, the aim of the present study was to evaluate the effects of Dental SKIN BioRegulation (Guna S.p.a., Milan, Italy), a new injectable medical device composed of type I collagen of porcine origin, on primary cultures of human gingival fibroblasts (hGF). To this end, hGF were cultured on collagen-coated (COL, 100 µg/2 mL) or uncoated plates (CTRL) before evaluating cell viability (24 h, 48 h, 72 h, and 7 d), wound healing properties (3 h, 6 h, 12 h, 24 h, and 48 h), and the activation of mechanotransduction markers, such as FAK, YAP, and TAZ (48 h). The results proved a significant increase in cell viability at 48 h (p < 0.05) and wound closure at 24 h (p < 0.001) of hGF grown on COL, with an increasing trend at all time-points. Furthermore, COL significantly induced the expression of FAK and YAP/TAZ (p < 0.05), thereby promoting the activation of mechanotransduction signaling pathways. Overall, these data suggest that COL, acting as a mechanical bio-scaffold, could represent a useful treatment for gingival rejuvenation and may possibly help in the resolution of oral pathologies. Full article
(This article belongs to the Special Issue Future Trends in Regenerative Medicine)
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