Epigenetic Regulation and Its Impact for Medicine
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 780
Special Issue Editor
Interests: epigenetics of human; etiopatogenesis of multifactorial diseases; immunogenetics of autoimmunity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The term epigenetics was first introduced by Conrad Waddington in 1942. For half a century, its significance to gene expression, cell differentiation and heritability was unclear. However, modern technologies that emerged at the beginning of the 21st century have opened a new area of research. The epigenetic regulation of the genome allow cells to react to external signals caused by the alternation of gene activity by modifying gene expression. Epigenome controls the accessibility of DNA for transcription factors that regulate the level of gene expression. Therefore, epigenetic modifications are the collective heritable changes in phenotype caused by the processes that arise independent of primary DNA sequence.
A major driving force in epigenetics has been the development of new technology that has not only stimulated new discoveries, but also expanded this field by allowing novel discoveries only possible through the use of these tools.
Plenty of studies have focused on the identification of possible biomarkers able to predict the onset of the disease, its activity degree, its progression phase and its response to disease-modifying drugs. Non-coding RNAs have the potential to serve as such biomarkers. These molecules can easily be detected in the peripheral blood or urine.
We encourage authors to submit articles and review papers about the role of epigenetic modulation in the etiopathology, prognosis and therapy of various diseases. We believe that this Special Issue will reflect the new era of epigenetics and show its important role in modern medicine.
Dr. Marie Černá
Guest Editor
Manuscript Submission Information
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Keywords
- gene expression
- DNA methylation
- histone modifications
- non-coding RNAs
- biomarkers
