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Biomedicines
Special Issues
Skin Tissue Regeneration and Wound Healing
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Skin Tissue Regeneration and Wound Healing

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1572

Special Issue Editors

Dr. Kazuo Kishi

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Guest Editor
Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, Tokyo, Japan
Interests: regeneration; skin; fetus
Special Issues, Collections and Topics in MDPI journals
Dr. Ryoichi Mori

E-Mail Website
Guest Editor
Department of Pathology, Nagasaki University School of Medicine and Graduate School of Biomedical Sciences, Nagasaki, Japan
Interests: skin wound healing; microrna; inflammation; live imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skin tissue regeneration and wound healing are complex processes that involve multiple cell types and molecular signaling pathways. There has been growing interest in developing new strategies for promoting skin tissue regeneration and wound healing. Nevertheless, there is still a lack of knowledge regarding the identification of key factors that can be modified to improve skin tissue regeneration and wound healing.

This Special Issue provides the recent advancements in the field of study, focusing on the role of the inflammatory response, production of the extracellular matrix from fibroblasts, the function of stem cells, evaluation of the biomimetic model, and the development of novel therapies including biomaterials and nanotherapeutics for non-healed and chronic wounds. Overall, this Special Issue provides crucial scientific information about skin tissue regeneration and wound healing for researchers and clinicians.

Dr. Kazuo Kishi
Dr. Ryoichi Mori
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammation
  • wound healing
  • scarring
  • regeneration

Published Papers (1 paper)

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Review

16 pages, 6215 KiB  
Review
Perspectives on the Current State of Bioprinted Skin Substitutes for Wound Healing
by Celena A. Sörgel, Aijia Cai, Rafael Schmid and Raymund E. Horch
Biomedicines 2023, 11(10), 2678; https://doi.org/10.3390/biomedicines11102678 - 29 Sep 2023
Cited by 3 | Viewed by 1170
Abstract
Human skin is particularly vulnerable to external damaging influences such as irradiation, extreme temperatures, chemical trauma, and certain systemic diseases, which reduce the skin’s capacity for regeneration and restoration and can possibly lead to large-scale skin defects. To restore skin continuity in severe [...] Read more.
Human skin is particularly vulnerable to external damaging influences such as irradiation, extreme temperatures, chemical trauma, and certain systemic diseases, which reduce the skin’s capacity for regeneration and restoration and can possibly lead to large-scale skin defects. To restore skin continuity in severe cases, surgical interventions such as the transplantation of autologous tissue are needed. Nevertheless, the coverage of larger skin defects caused by severe third-grade burns or extensive irradiation therapy is limited due to the depletion of uninjured autologous tissue. In such cases, many of the patient’s epidermal cells can become available using biofabricated skin grafts, thereby restoring the skin’s vital functions. Given the limited availability of autologous skin grafts for restoring integrity in large-scale defects, using bioprinted constructs as skin graft substitutes could offer an encouraging therapeutic alternative to conventional therapies for large-scale wounds, such as the transplantation of autologous tissue. Using layer-by-layer aggregation or volumetric bioprinting, inkjet bioprinting, laser-assisted bioprinting, or extrusion-based bioprinting, skin cells are deposited in a desired pattern. The resulting constructs may be used as skin graft substitutes to accelerate wound healing and reconstitute the physiological functions of the skin. In this review, we aimed to elucidate the current state of bioprinting within the context of skin tissue engineering and introduce and discuss different bioprinting techniques, possible approaches and materials, commonly used cell types, and strategies for graft vascularization for the production of bioprinted constructs for use as skin graft substitutes. Full article
(This article belongs to the Special Issue Skin Tissue Regeneration and Wound Healing)
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