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Biomedicines
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Advances on Nanomaterials Derived from Natural Resources and Their Biomedical...
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Advances on Nanomaterials Derived from Natural Resources and Their Biomedical Applications

A special issue of Biomedicines (ISSN 2227-9059).

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 5738

Special Issue Editors

Dr. Kaliannan Durairaj

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Guest Editor
Zoonosis Research Center, Department of Infection Biology, School of Medicine, Wonkwang University, Iksan, Korea
Interests: nanomaterial; hybrid nanocomposites; biomedical engineering; infectious biology
Prof. Dr. Vijaya Anand

E-Mail Website
Guest Editor
Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore - 46, Tamil Nadu, India
Interests: phytotherapeutics; clinical biochemistry; medical genetics and epigenetics
Dr. Balamuralikrishnan Balasubramanian

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Guest Editor
Department of Food Science and Biotechnology, College of Life Sciences, Sejong University, 209 Neungdong-ro, Gunja-dong, Gwangjin-gu, Seoul, Republic of Korea
Interests: animal science; bioactive compounds of natural products; biomedical; nutrients; metabolites
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Naturally derived biomaterials are nanomaterials with unique biological activities, representing an imminent and promising area of research. In recent decades, advances in biomedical engineering have introduced novel development opportunities for bioactive materials. However, bionanomaterials are a new class of materials widely utilized in specified biomedical sciences, such as the development of biosensors, cancer therapy, drug delivery of therapeutics, diagnosis of infectious disease, and tissue engineering. They have significant effects due to their variety of composition, nanoscale size effect, nanostructures, surface area, and other functional group properties.  Further, current and future applications ensure that biomaterials have high hypothetical and clinical importance. We invite researchers from different fields to contribute their original research and review articles to explore the theme of this Special Issue.

Dr. Kaliannan Durairaj
Dr. Arumugam Vijaya Anand
Dr. Balamuralikrishnan Balasubramanian
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant-derived nanomaterials
  • hybrid nanocomposites
  • pharmaceutical agents
  • anti-inflammatory activity
  • antimicrobial activity
  • anticancer activity
  • in vitro/in vivo studies

Published Papers (3 papers)

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Research

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11 pages, 2020 KiB  
Article
Assessing the Layer-by-Layer Assembly of Cellulose Nanofibrils and Polyelectrolytes in Pancreatic Tumor Spheroid Formation
by Negar Abbasi Aval, Ekeram Lahchaichi, Oana Tudoran, Farzaneh Fayazbakhsh, Rainer Heuchel, Matthias Löhr, Torbjörn Pettersson and Aman Russom
Biomedicines 2023, 11(11), 3061; https://doi.org/10.3390/biomedicines11113061 - 15 Nov 2023
Viewed by 1132
Abstract
Three-dimensional (3D) tumor spheroids are regarded as promising models for utilization as preclinical assessments of chemo-sensitivity. However, the creation of these tumor spheroids presents challenges, given that not all tumor cell lines are able to form consistent and regular spheroids. In this context, [...] Read more.
Three-dimensional (3D) tumor spheroids are regarded as promising models for utilization as preclinical assessments of chemo-sensitivity. However, the creation of these tumor spheroids presents challenges, given that not all tumor cell lines are able to form consistent and regular spheroids. In this context, we have developed a novel layer-by-layer coating of cellulose nanofibril–polyelectrolyte bilayers for the generation of spheroids. This technique builds bilayers of cellulose nanofibrils and polyelectrolytes and is used here to coat two distinct 96-well plate types: nontreated/non-sterilized and Nunclon Delta. In this work, we optimized the protocol aimed at generating and characterizing spheroids on difficult-to-grow pancreatic tumor cell lines. Here, diverse parameters were explored, encompassing the bilayer count (five and ten) and multiple cell-seeding concentrations (10, 100, 200, 500, and 1000 cells per well), using four pancreatic tumor cell lines—KPCT, PANC-1, MiaPaCa-2, and CFPAC-I. The evaluation includes the quantification (number of spheroids, size, and morphology) and proliferation of the produced spheroids, as well as an assessment of their viability. Notably, our findings reveal a significant influence from both the number of bilayers and the plate type used on the successful formation of spheroids. The novel and simple layer-by-layer-based coating method has the potential to offer the large-scale production of spheroids across a spectrum of tumor cell lines. Full article
(This article belongs to the Special Issue Advances on Nanomaterials Derived from Natural Resources and Their Biomedical Applications)
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16 pages, 10649 KiB  
Article
Cytotoxic Effects of Nanoliposomal Cisplatin and Diallyl Disulfide on Breast Cancer and Lung Cancer Cell Lines
by Kaavya Gunasekaran, Bala Murali Krishna Vasamsetti, Priyadharshini Thangavelu, Karthi Natesan, Bonaventure Mujyambere, Viswanathan Sundaram, Rama Jayaraj, Yeon-Jun Kim, Suja Samiappan and Jae-Won Choi
Biomedicines 2023, 11(4), 1021; https://doi.org/10.3390/biomedicines11041021 - 27 Mar 2023
Cited by 1 | Viewed by 1814
Abstract
Dual drug delivery has become the choice of interest nowadays due to its increased therapeutic efficacy in targeting the tumor site precisely. As quoted in recent literature, it has been known to treat several cancers with an acute course of action. Even so, [...] Read more.
Dual drug delivery has become the choice of interest nowadays due to its increased therapeutic efficacy in targeting the tumor site precisely. As quoted in recent literature, it has been known to treat several cancers with an acute course of action. Even so, its use is restricted due to the drug’s low pharmacological activity, which leads to poor bioavailability and increases first-pass metabolism. To overcome these issues, a drug delivery system using nanomaterials which would not only encapsulate the drugs of interest but also carry them to the target site of action is needed. Given all these attributes, we have formulated dual drug-loaded nanoliposomes with cisplatin (cis-diamminedichloroplatinum(II) (CDDP)), an effective anti-cancer drug, and diallyl disulfide (DADS), an organosulfur compound derived from garlic. The CDDP and DADS-loaded nanoliposomes (Lipo-CDDP/DADS) exhibited better physical characteristics such as size, zeta potential, polydispersity index, spherical shape, optimal stability, and satisfactory encapsulation percentage. The in vitro anti-cancer activity against MDA-MB-231 and A549 cell lines revealed that Lipo-CDDP/DADS showed significant efficacy against the cancer cell lines, depicted through cell nucleus staining. We conclude that Lipo-CDDP/DADS hold exceptional pharmacological properties with better anti-cancer activity and would serve as a promising formulation to treat various cancers. Full article
(This article belongs to the Special Issue Advances on Nanomaterials Derived from Natural Resources and Their Biomedical Applications)
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Review

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19 pages, 27178 KiB  
Review
Recent Biomedical Applications of Coupling Nanocomposite Polymeric Materials Reinforced with Variable Carbon Nanofillers
by Abeer M. Alosaimi, Randa O. Alorabi, Dina F. Katowah, Zahrah T. Al-Thagafi, Eman S. Alsolami, Mahmoud A. Hussein, Mohammad Qutob and Mohd Rafatullah
Biomedicines 2023, 11(3), 967; https://doi.org/10.3390/biomedicines11030967 - 21 Mar 2023
Cited by 4 | Viewed by 1555
Abstract
The hybridization between polymers and carbon materials is one of the most recent and crucial study areas which abstracted more concern from scientists in the past few years. Polymers could be classified into two classes according to the source materials synthetic and natural. [...] Read more.
The hybridization between polymers and carbon materials is one of the most recent and crucial study areas which abstracted more concern from scientists in the past few years. Polymers could be classified into two classes according to the source materials synthetic and natural. Synthetic polymeric materials have been applied over a floppy zone of industrial fields including the field of biomedicine. Carbon nanomaterials including (fullerene, carbon nanotubes, and graphene) classified as one of the most significant sources of hybrid materials. Nanocarbons are improving significantly mechanical properties of polymers in nanocomposites in addition to physical and chemical properties of the new materials. In all varieties of proposed bio-nanocomposites, a considerable improvement in the microbiological performance of the materials has been explored. Various polymeric materials and carbon-course nanofillers were present, along with antibacterial, antifungal, and anticancer products. This review spots the light on the types of synthetic polymers-based carbon materials and presented state-of-art examples on their application in the area of biomedicine. Full article
(This article belongs to the Special Issue Advances on Nanomaterials Derived from Natural Resources and Their Biomedical Applications)
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