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Pain: Neurobiology, Pathophysiology, and Therapeutic Approaches
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Pain: Neurobiology, Pathophysiology, and Therapeutic Approaches

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Neuroscience".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 9272

Special Issue Editor

Dr. Joshua W. Little

E-Mail Website
Guest Editor
Adams School of Dentistry, University of North Carolina-Chapel Hill, 385 S. Columbia Street, Chapel-Hill, NC 27599, USA
Interests: neurobiology; pain (efficacy of treatments, musculoskeletal, glial-mediated mechanisms, sex differences, health disparities)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pain, including chronic pain, is a global socioeconomic problem that has only been worsened by the opioid epidemic. The multidisciplinary field of pain must continue to evolve and bring forward new insights into the neurobiology of pain, the pathophysiological mechanisms underlying acute and chronic pain, and innovative pharmacological or nonpharmacological approaches to provide nonopioid options for better pain management.

The Special Issue will highlight pain research related to neurobiology, pathophysiology, and therapy, fitting well within the broad scope of the Neuroscience Section in Biology.                                

Original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: pain neurobiology, pathology of diseases that cause pain, pain therapies, pathophysiological pain mechanisms, biomedical imaging of pain, mechanisms of pain, novel pain therapies, and pain management to reduce and/or replace opioid medications.

I look forward to receiving your contributions.

You may choose our Joint Special Issue in Cells.

Dr. Joshua W. Little
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pain
  • pain pathophysiology
  • neurobiology
  • nonopioid therapy
  • acute pain
  • chronic pain

Published Papers (4 papers)

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Research

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12 pages, 1310 KiB  
Article
Prevalence of Ponticulus Posticus and Migraine in 220 Orthodontic Patients: A Cross-Sectional Study
by Monica Macrì, Fabiola Rendina, Beatrice Feragalli, Francesco Pegreffi and Felice Festa
Biology 2023, 12(3), 471; https://doi.org/10.3390/biology12030471 - 20 Mar 2023
Cited by 4 | Viewed by 1908
Abstract
Background: Ponticulus posticus (PP) is a medical term that describes an anomaly of the atlas (C1), which has a complete or partial bone bridge over the vertebral artery (VA) groove. The purpose of the study is to estimate the prevalence of PP in [...] Read more.
Background: Ponticulus posticus (PP) is a medical term that describes an anomaly of the atlas (C1), which has a complete or partial bone bridge over the vertebral artery (VA) groove. The purpose of the study is to estimate the prevalence of PP in patients with a diagnosis of migraine. Methods: Cone beam CT (CBCT) scans (n = 220) were reviewed for the detection of PP in the University “G. D’Annunzio” of Chieti in the Department of Medical, Oral and Biotechnological Sciences. The sample included 220 Italian patients between 18 and 87 years. Pearson chi-square analysis (p < 0.05 and 95% CI) was used to establish an association between migraine and PP. Results: The present study found a prevalence of PP of 20.9% and a prevalence of migraine of 12.272%. The association between migraine and PP was confirmed by the chi-square statistic, since the p-value was 0.008065 (significant at p < 0.05). PP was more frequent in the migraine without aura group, without a statistical difference relative to the migraine with aura group. Conclusions. The study concluded that PP is positively associated with migraine. Full article
(This article belongs to the Special Issue Pain: Neurobiology, Pathophysiology, and Therapeutic Approaches)
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23 pages, 10181 KiB  
Article
The NGF R100W Mutation, Associated with Hereditary Sensory Autonomic Neuropathy Type V, Specifically Affects the Binding Energetic Landscapes of NGF and of Its Precursor proNGF and p75NTR
by Sonia Covaceuszach and Doriano Lamba
Biology 2023, 12(3), 364; https://doi.org/10.3390/biology12030364 - 25 Feb 2023
Viewed by 1504
Abstract
Nerve Growth Factor (NGF), the prototype of the neurotrophin family, stimulates morphological differentiation and regulates neuronal gene expression by binding to TrkA and p75NTR receptors. It plays a critical role in maintaining the function and phenotype of peripheral sensory and sympathetic neurons and [...] Read more.
Nerve Growth Factor (NGF), the prototype of the neurotrophin family, stimulates morphological differentiation and regulates neuronal gene expression by binding to TrkA and p75NTR receptors. It plays a critical role in maintaining the function and phenotype of peripheral sensory and sympathetic neurons and in mediating pain transmission and perception during adulthood. A point mutation in the NGFB gene (leading to the amino acid substitution R100W) is responsible for Hereditary Sensory and Autonomic Neuropathy type V (HSAN V), leading to a congenital pain insensitivity with no clear cognitive impairments, but with alterations in the NGF/proNGF balance. The available crystal structures of the p75NTR/NGF and 2p75NTR/proNGF complexes offer a starting point for Molecular Dynamics (MD) simulations in order to capture the impact of the R100W mutation on their binding energetic landscapes and to unveil the molecular determinants that trigger their different physiological and pathological outcomes. The present in silico studies highlight that the stability and the binding energetic fingerprints in the 2p75NTR/proNGF complex is not affected by R100W mutation, which on the contrary, deeply affects the energetic landscape, and thus the stability in the p75NTR/NGF complex. Overall, these findings present insights into the structural basis of the molecular mechanisms beyond the clinical manifestations of HSAN V patients. Full article
(This article belongs to the Special Issue Pain: Neurobiology, Pathophysiology, and Therapeutic Approaches)
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Review

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16 pages, 1891 KiB  
Review
Post-Traumatic Trigeminal Neuropathy: Neurobiology and Pathophysiology
by Tal Eliav, Rafael Benoliel and Olga A. Korczeniewska
Biology 2024, 13(3), 167; https://doi.org/10.3390/biology13030167 - 04 Mar 2024
Viewed by 1267
Abstract
Painful traumatic trigeminal neuropathy (PTTN) is a chronic neuropathic pain that may develop following injury to the trigeminal nerve. Etiologies include cranio-orofacial trauma that may result from dental, surgical, or anesthetic procedures or physical trauma, such as a motor vehicle accident. Following nerve [...] Read more.
Painful traumatic trigeminal neuropathy (PTTN) is a chronic neuropathic pain that may develop following injury to the trigeminal nerve. Etiologies include cranio-orofacial trauma that may result from dental, surgical, or anesthetic procedures or physical trauma, such as a motor vehicle accident. Following nerve injury, there are various mechanisms, including peripheral and central, as well as phenotypic changes and genetic predispositions that may contribute to the development of neuropathic pain. In this article, we review current literature pertaining to the cellular processes that occur following traumatic damage to the trigeminal nerve, also called cranial nerve V, that results in chronic neuropathic pain. We examine the neurobiology and pathophysiology based mostly on pre-clinical animal models of neuropathic/trigeminal pain. Full article
(This article belongs to the Special Issue Pain: Neurobiology, Pathophysiology, and Therapeutic Approaches)
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12 pages, 1319 KiB  
Review
Erector Spinae Plane Block and Chronic Pain: An Updated Review and Possible Future Directions
by Alessandro De Cassai, Federico Geraldini, Ulderico Freo, Annalisa Boscolo, Tommaso Pettenuzzo, Francesco Zarantonello, Nicolò Sella, Serkan Tulgar, Veronica Busetto, Sebastiano Negro, Marina Munari and Paolo Navalesi
Biology 2023, 12(8), 1073; https://doi.org/10.3390/biology12081073 - 01 Aug 2023
Cited by 1 | Viewed by 4046
Abstract
Chronic pain is a common, pervasive, and often disabling medical condition that affects millions of people worldwide. According to the Global Burden of Disease survey, painful chronic conditions are causing the largest numbers of years lived with disability worldwide. In America, more than [...] Read more.
Chronic pain is a common, pervasive, and often disabling medical condition that affects millions of people worldwide. According to the Global Burden of Disease survey, painful chronic conditions are causing the largest numbers of years lived with disability worldwide. In America, more than one in five adults experiences chronic pain. Erector spinae plane block is a novel regional anesthesia technique used to provide analgesia with multiple possible uses and a relatively low learning curve and complication rate. Here, we review the erector spinae plane block rationale, mechanism of action and possible complications, and discuss its potential use for chronic pain with possible future directions for research Full article
(This article belongs to the Special Issue Pain: Neurobiology, Pathophysiology, and Therapeutic Approaches)
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