Cellular and Molecular Regulation of Inflammatory Diseases

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cell Biology".

Deadline for manuscript submissions: closed (15 April 2022) | Viewed by 6669

Special Issue Editors


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Guest Editor
Department of Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA
Interests: macrophages; inflammation; obesity; atherosclerosis; cancer

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Guest Editor
Department of the Critical Care Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
Interests: immune; Sepsis; molecular biology

Special Issue Information

Dear Colleagues,

There are too many pathogenic factors on the planet. Bacteria or viruses may induce acute cytokine storms, such as sepsis. Diabetes and obesity can develop over time if we eat incorrectly. Pollen may make our eyes itch and our nose run. Even chronic psychological stress may make cancer worse. All these stimuli will alert our defense system—the immune system in the first step. In particular, our immune system sometimes may mistakenly injure a part of our body and cause autoimmune disease. Cancer may grow silently when the immune system is out of control. At the cellular level, frontline cells (such as neutrophils, monocytes, or macrophages) are challenged to protect us and simultaneously release signals to other cells to maintain homeostasis. At the molecular level, extracellular signals are transduced intracellularly in these frontier cells or recruited cells and induce the alterations of genes and proteins. In this way, the immune system is regulated and responds to all disease malfunctions through horizontal and vertical interactions.

In this Special Issue, we encourage the submission of manuscripts on any aspect of the regulation of any inflammatory diseases at the cellular or molecular level. We accept reviews, conference proceedings, short and full-length research papers, technical advances, bioinformatics analyses, and studies that address the above topics.

Dr. Xianfeng Wang
Dr. Vidula Vachharajani
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammatory diseases
  • acute infection
  • chronic inflammation
  • autoimmune
  • cancer
  • signal transduction
  • bioinformatics
  • cellular biology
  • molecular biology
  • disease modulation

Published Papers (2 papers)

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Research

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13 pages, 1392 KiB  
Article
SERPINE1 rs6092 Variant Is Related to Plasma Coagulation Proteins in Patients with Severe COVID-19 from a Tertiary Care Hospital
by Ingrid Fricke-Galindo, Ivette Buendia-Roldan, Leslie Chavez-Galan, Gloria Pérez-Rubio, Rafael de Jesús Hernández-Zenteno, Espiridión Ramos-Martinez, Armando Zazueta-Márquez, Felipe Reyes-Melendres, Aimé Alarcón-Dionet, Javier Guzmán-Vargas, Omar Andrés Bravo-Gutiérrez, Teresa Quintero-Puerta, Ilse Adriana Gutiérrez-Pérez, Alejandro Ortega-Martínez, Enrique Ambrocio-Ortiz, Karol J. Nava-Quiroz, José Luis Bañuelos-Flores, María Esther Jaime-Capetillo, Mayra Mejía, Jorge Rojas-Serrano and Ramcés Falfán-Valenciaadd Show full author list remove Hide full author list
Biology 2022, 11(4), 595; https://doi.org/10.3390/biology11040595 - 14 Apr 2022
Cited by 6 | Viewed by 3308
Abstract
An impaired coagulation process has been described in patients with severe or critical coronavirus disease (COVID-19). Nevertheless, the implication of coagulation-related genes has not been explored. We aimed to evaluate the impact of F5 rs6025 and SERPINE1 rs6092 on invasive mechanical ventilation (IMV) [...] Read more.
An impaired coagulation process has been described in patients with severe or critical coronavirus disease (COVID-19). Nevertheless, the implication of coagulation-related genes has not been explored. We aimed to evaluate the impact of F5 rs6025 and SERPINE1 rs6092 on invasive mechanical ventilation (IMV) requirement and the levels of coagulation proteins among patients with severe COVID-19. Four-hundred fifty-five patients with severe COVID-19 were genotyped using TaqMan assays. Coagulation-related proteins (P-Selectin, D-dimer, P-selectin glycoprotein ligand-1, tissue plasminogen activator [tPA], plasminogen activator inhibitor-1, and Factor IX) were assessed by cytometric bead arrays in one- and two-time determinations. Accordingly, SERPINE1 rs6092, P-Selectin (GG 385 pg/mL vs. AG+AA 632 pg/mL, p = 0.0037), and tPA (GG 1858 pg/mL vs. AG+AA 2546 pg/mL, p = 0.0284) levels were different. Patients carrying the CT F5-rs6025 genotype exhibited lower levels of factor IX (CC 17,136 pg/mL vs. CT 10,247 pg/mL, p = 0.0355). Coagulation proteins were also different among IMV patients than non-IMV. PSGL-1 levels were significantly increased in the late stage of COVID-19 (>10 days). The frequencies of F5 rs6025 and SERPINE1 rs6092 variants were not different among IMV and non-IMV. The SERPINE1 rs6092 variant is related to the impaired coagulation process in patients with COVID-19 severe. Full article
(This article belongs to the Special Issue Cellular and Molecular Regulation of Inflammatory Diseases)
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Review

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18 pages, 3439 KiB  
Review
Molecular Mechanisms and Key Processes in Interstitial, Hemorrhagic and Radiation Cystitis
by Clément Brossard, Anne-Charlotte Lefranc, Anne-Laure Pouliet, Jean-Marc Simon, Marc Benderitter, Fabien Milliat and Alain Chapel
Biology 2022, 11(7), 972; https://doi.org/10.3390/biology11070972 - 28 Jun 2022
Cited by 4 | Viewed by 2470
Abstract
Cystitis is a bladder disease with a high rate of prevalence in the world population. This report focuses on Interstitial Cystitis (IC), Hemorrhagic Cystitis (HC) and Chronic Radiation Cystitis. These pathologies have different etiologies, but they share common symptoms, for instance, pain, bleeding, [...] Read more.
Cystitis is a bladder disease with a high rate of prevalence in the world population. This report focuses on Interstitial Cystitis (IC), Hemorrhagic Cystitis (HC) and Chronic Radiation Cystitis. These pathologies have different etiologies, but they share common symptoms, for instance, pain, bleeding, and a contracted bladder. Overall, treatments are quite similar for abacterial cystitis, and include bladder epithelium protective or anti-inflammatory agents, alleviating pain and reducing bleeding. This review summarizes the mechanisms that the pathologies have in common, for instance, bladder dysfunction and inflammation. Conversely, some mechanisms have been described as present in only one pathology, such as neural regulation. Based on these specificities, we propose identifying a mechanism that could be common to all the above-mentioned pathologies. Full article
(This article belongs to the Special Issue Cellular and Molecular Regulation of Inflammatory Diseases)
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