Metabolic Interactions between the Gut Microbiome and Host

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Microbiology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1344

Special Issue Editors

Academy of National Food and Strategic Reserves Administration, Beijing 100037, China
Interests: intestinal microbiome; probiotics; intestinal barrier; metabolome; intestinal innate immunity
State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
Interests: nutrition; gut microbiota; IBD; NAFLD; intestinal barrier function
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The symbiotic relationship between the gut microbiota and the host imparts metabolic, immune, and intestinal protective functions to healthy individuals. This interaction is largely determined by factors such as nutritional status and lifestyle habits. Diet is a major driver in shaping the gut microecosystem, which provides selective growth advantages for specific species of bacteria. Long-term dietary intervention can regulate the composition and function of intestinal microbiota in both humans and animals. Simultaneously, the metabolic activity of gut microbes also has an important impact on host health and the metabolic phenotype of the host, which can be beneficial or harmful. Gut microbiota imbalance is closely related to the occurrence and development of chronic metabolic diseases, such as diabetes, obesity, inflammatory bowel disease, cardiovascular disease, depression, tumor, and so on. Therefore, it is vital to reveal the strain specificity that produces microbial metabolites, which will facilitate the identification and discovery of strains or specific metabolites for diseases for therapeutic purposes.

This Special Issue focuses on “Metabolic Interactions between the Gut Microbiome and Host” and welcomes the submission of original research and review articles focusing on the causal relationship and its intrinsic mechanisms between the gut microbiome and the host; however, research on new methods and technologies employed for studying key bacteria and their specific molecules, microbial heterogeneity, that will help us to understand the gut microbiota in depth is also welcome. This Special Issue will enlighten readers about new discoveries, advances, and developments in microbiome-related disease therapeutics.

Dr. Weiwei Wang
Dr. Yun Ji
Guest Editors

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  • gut microbiome
  • host
  • metabolome
  • microbial heterogeneity
  • biomolecules

Published Papers (1 paper)

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16 pages, 1581 KiB  
Blood Metabolites and Faecal Microbial Communities in Nonpregnant and Early Gestation Ewes in Highly Cold Areas
Biology 2023, 12(11), 1436; - 16 Nov 2023
Viewed by 955
Ewes undergo complex metabolic changes during pregnancy. Understanding the specific process of these changes is a necessary prerequisite in ewes for regulating and intervening in order to maintain pregnancies. However, there have been relatively few studies on the specific changes that occur in [...] Read more.
Ewes undergo complex metabolic changes during pregnancy. Understanding the specific process of these changes is a necessary prerequisite in ewes for regulating and intervening in order to maintain pregnancies. However, there have been relatively few studies on the specific changes that occur in nutritional metabolism in pregnant ewes during early gestation, especially for some landrace ewes in highly cold areas. Therefore, this study aimed to (1) elucidate the changes in metabolites and microbial communities in pregnant ewes during early gestation using metabolomics and 16S ribosomal RNA gene (rDNA) amplicon sequencing approaches, and to (2) discover novel early pregnancy-induced biomarkers in the blood and faeces. Rams were placed together with ewes on D0 and removed on D45. During early gestation, blood and faecal samples were collected from ewes in a highly cold area for analysing the metabolites and microbial communities; these were retrospectively classified as the early gestation pregnant (EP) ewe group or the nonpregnant (NP) ewe group based on the lambing status recorded during the expected delivery period. The differences in the plasma biochemical parameters, plasma metabolites, and faecal microbial communities of pregnant and nonpregnant ewes were characterised. The GC, IL-6, O-acetyl-l-serine, L-glutamine, and 6-acetamido-2-oxohexanoic acid were screened out as potential biomarkers for evaluating the occurrence of early pregnancy. These novel early pregnancy-induced metabolites discovered in ewes might allow for the development of technologies to detect early pregnancies in sheep in highly cold areas. Full article
(This article belongs to the Special Issue Metabolic Interactions between the Gut Microbiome and Host)
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