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Bioengineering
Special Issues
3D Bioprinting Advanced Vascularized Tissues and Organs
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3D Bioprinting Advanced Vascularized Tissues and Organs

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 7140

Special Issue Editors

Prof. Dr. Jeremy M. Crook

E-Mail Website
Guest Editor
1. Biomedical Innovation, Chris O`Brien Lifehouse, Camperdown, NSW 2050, Australia
2. School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW 2006, Australia
Interests: stem cell biology; cancer cell biology; neurobiology; biomaterials; electroceuticals; organoids; tissue engineering; bioprinting; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Carmine Gentile

E-Mail Website
Guest Editor
School of Biomedical Engineering, University of Technology Sydney, Ultimo, NSW 2007, Australia
Interests: 3D bioprinting; stem cells; regenerative medicine; cardiovascular pathophysiology and pharmacology; in vitro disease modeling; bioinks; spheroids

Special Issue Information

Dear Colleagues,

3D bioprinting has emerged as a developing opportunity to biofabricate viable and functional tissues for preclinical and clinical applications. 3D bioprinting comprises a diversity of approaches, including extrusion-, ink-jet- and stereolithography-based printing platforms, to name a few. Despite its scalability, reproducibility, and precision in locating cells according to a desired geometry, a major challenge with bioprinting tissues remains the recapitulation of a robust functional vascular network, necessary for the transportation of nutrients and oxygen throughout engineered constructs, as well as the elimination of cellular waste and CO2.

This Special Issue covers recent developments in vascular tissue engineering and related key features of 3D-bioprinting platforms, with a particular focus on technical requirements for the recapitulation of native vasculature. It includes advanced methods and biomaterials for vascularizing bioinks, together with perspectives on the optimal use of vascularized 3D bioprinted tissues for disease modeling, high-throughput screening of drugs, tissue replacement therapy and medical device development.

Prof. Dr. Jeremy M. Crook
Dr. Carmine Gentile
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 3D bioprinting
  • bioink
  • tissue engineering
  • vascularized tissue
  • additive manufacturing
  • bioprinting
  • vasculature

Published Papers (2 papers)

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Research

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19 pages, 6982 KiB  
Article
Bioprinting of Perfusable, Biocompatible Vessel-like Channels with dECM-Based Bioinks and Living Cells
by Marta Klak, Michał Rachalewski, Anna Filip, Tomasz Dobrzański, Andrzej Berman and Michał Wszoła
Bioengineering 2024, 11(5), 439; https://doi.org/10.3390/bioengineering11050439 - 29 Apr 2024
Viewed by 185
Abstract
There is a growing interest in the production of bioinks that on the one hand, are biocompatible and, on the other hand, have mechanical properties that allow for the production of stable constructs that can survive for a long time after transplantation. While [...] Read more.
There is a growing interest in the production of bioinks that on the one hand, are biocompatible and, on the other hand, have mechanical properties that allow for the production of stable constructs that can survive for a long time after transplantation. While the selection of the right material is crucial for bioprinting, there is another equally important issue that is currently being extensively researched—the incorporation of the vascular system into the fabricated scaffolds. Therefore, in the following manuscript, we present the results of research on bioink with unique physico-chemical and biological properties. In this article, two methods of seeding cells were tested using bioink B and seeding after bioprinting the whole model. After 2, 5, 8, or 24 h of incubation, the flow medium was used in the tested systems. At the end of the experimental trial, for each time variant, the canals were stored in formaldehyde, and immunohistochemical staining was performed to examine the presence of cells on the canal walls and roof. Cells adhered to both ways of fiber arrangement; however, a parallel bioprint with the 5 h incubation and the intermediate plating of cells resulted in better adhesion efficiency. For this test variant, the percentage of cells that adhered was at least 20% higher than in the other analyzed variants. In addition, it was for this variant that the lowest percentage of viable cells was found that were washed out of the tested model. Importantly, hematoxylin and eosin staining showed that after 8 days of culture, the cells were evenly distributed throughout the canal roof. Our study clearly shows that neovascularization-promoting cells effectively adhere to ECM-based pancreatic bioink. Summarizing the presented results, it was demonstrated that the proposed bioink compositions can be used for bioprinting bionic organs with a vascular system formed by endothelial cells and fibroblasts. Full article
(This article belongs to the Special Issue 3D Bioprinting Advanced Vascularized Tissues and Organs)
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Review

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16 pages, 1200 KiB  
Review
Taking It Personally: 3D Bioprinting a Patient-Specific Cardiac Patch for the Treatment of Heart Failure
by Niina Matthews, Berto Pandolfo, Daniel Moses and Carmine Gentile
Bioengineering 2022, 9(3), 93; https://doi.org/10.3390/bioengineering9030093 - 25 Feb 2022
Cited by 5 | Viewed by 6708
Abstract
Despite a massive global preventative effort, heart failure remains the major cause of death globally. The number of patients requiring a heart transplant, the eventual last treatment option, far outnumbers the available donor hearts, leaving many to deteriorate or die on the transplant [...] Read more.
Despite a massive global preventative effort, heart failure remains the major cause of death globally. The number of patients requiring a heart transplant, the eventual last treatment option, far outnumbers the available donor hearts, leaving many to deteriorate or die on the transplant waiting list. Treating heart failure by transplanting a 3D bioprinted patient-specific cardiac patch to the infarcted region on the myocardium has been investigated as a potential future treatment. To date, several studies have created cardiac patches using 3D bioprinting; however, testing the concept is still at a pre-clinical stage. A handful of clinical studies have been conducted. However, moving from animal studies to human trials will require an increase in research in this area. This review covers key elements to the design of a patient-specific cardiac patch, divided into general areas of biological design and 3D modelling. It will make recommendations on incorporating anatomical considerations and high-definition motion data into the process of 3D-bioprinting a patient-specific cardiac patch. Full article
(This article belongs to the Special Issue 3D Bioprinting Advanced Vascularized Tissues and Organs)
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