Special Issue "Model Systems for Human Disease and Medicine: From Advanced Cell and Tissue Culture to In Silico Methods"
Deadline for manuscript submissions: 15 May 2024 | Viewed by 3440
2. School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia
3. Intelligent Polymer Research Institute, AIIM Facility, University of Wollongong, Fairy Meadow, NSW 2519, Australia
Interests: biomedical engineering; regenerative medicine (incl. stem cells); cancer therapy; medical devices
Special Issues, Collections and Topics in MDPI journals
Special Issue in Cells: Cell Biology: State-of-the-Art and Perspectives in Australia
Special Issue in Bioengineering: 3D Bioprinting Advanced Vascularized Tissues and Organs
Advances in the understanding and treatment of human diseases, whether of unknown (idiopathic) or known origin, are increasingly reliant upon non-animal laboratory-based modelling of cell and tissue biology as well as contributing risk factors. Notwithstanding the many different approaches to modelling, ranging from in vitro-engineered and patient-derived three-dimensional (3D) cell and tissue culture systems (e.g., bioprinted, organoid, cell-on-a-chip) to in silico (computer-based) methods that leverage data from real patients (e.g., genomic, proteomic, metabolomic, pharmacologic, and clinical trials data), an effective model must accurately recapitulate or simulate complex higher-level physiological and pathological aspects of human biology, including therapeutic response in a representative context (i.e., environment). By doing so, biological processes are being identified that are specific to human pathobiology and treatment response, unable to be modelled in a classical animal system. Modelling can be especially important for rare diseases with small patient populations, where both live cell/tissue-based and in silico methods provide scientifically robust frameworks for assessing disease mechanisms and treatment efficacy where it may not be feasible to conduct a clinical trial requiring actual patients only.
This Special Issue will provide a forum to discuss and reflect on the latest progress in laboratory-based modelling for human disease and medicine, ranging from advanced cell and tissue culture to in silico methods, including but not limited to the topics of disease cell and tissue (e.g., developmental, degenerative, cancer, etc.); tissue specific stem cell; native or induced pluripotent stem cell; organoid; cell- and organ-on-a-chip technologies; and cell, gene, and drug therapy. A wide range of contributions are therefore encouraged, including original research reports, review articles, and perspective articles to summarize and reflect on the progress for a specific topic.
We look forward to your contributions.
Prof. Dr. Jeremy Micah Crook
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- human model systems
- in vitro
- stem cells
- pluripotent stem cells
- in silico
- regenerative medicine