Emerging Topics in Precision Medicine: Non-invasive Innovations Shaping Cancer and Immunotherapy Progress

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 829

Special Issue Editors


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Guest Editor
Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, USA
Interests: lymphoma; tumor microenvironment; immunotherapy; artificial intelligence
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, USA
Interests: computational systems biology; systems immunology; translational systems biology; drug discovery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Immunotherapy, which harnesses the power of immune cells, holds promise in enhancing clinical outcomes, yet is challenged by cancer heterogeneity, variable therapy response, and the development of resistance. Despite several advanced clinical approaches, cancer remains the second-most deadly disease in the world. Therefore, comprehending cancer heterogeneity and immunotherapy response is crucial to optimize personalized therapeutic interventions based on individual tumors. With the integration of big data in medical applications, the incorporation of diverse biomedical data, ranging from molecular to imaging, provides a high-dimensional visualization of cancer behavior. This enables cancer stratification, diagnosis, and therapy management. Thus, the utilization of multimodal data fusion will open avenues for the development of advanced non-invasive investigations, addressing the challenges of cancer intricacies and enhancing the precision of personalized treatment strategies.

The topic welcomes reviews and research articles in computational non-invasive approaches including, but not limited to, radiomics, radiogenomics, computational models, and artificial intelligence methods. 

Dr. Rada Amin
Dr. Bhanwar Lal Puniya
Guest Editors

Manuscript Submission Information

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Keywords

  • cancer
  • immunotherapy
  • computational biology
  • radiogenomics
  • radiomics
  • in silico systems
  • drug delivery
  • non-invasive approaches

Published Papers (1 paper)

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Review

27 pages, 1177 KiB  
Review
Characteristics of the Colorectal Cancer Microenvironment—Role in Cancer Progression and Therapeutic Possibilities
by Paulina Pieniądz, Mateusz Pięt and Roman Paduch
Appl. Sci. 2024, 14(7), 2930; https://doi.org/10.3390/app14072930 - 30 Mar 2024
Viewed by 603
Abstract
Colorectal cancer (CRC) is one of the most common and deadliest cancers worldwide. According to the GLOBOCAN (WHO) report in 2020, nearly 2 million patients were diagnosed globally. Despite the advances in cancer diagnosis and therapy, CRC remains a global challenge. Recently, attention [...] Read more.
Colorectal cancer (CRC) is one of the most common and deadliest cancers worldwide. According to the GLOBOCAN (WHO) report in 2020, nearly 2 million patients were diagnosed globally. Despite the advances in cancer diagnosis and therapy, CRC remains a global challenge. Recently, attention has been paid to the tumor microenvironment (TME), which constitutes a significant part of the tumor and mainly includes various immune cells, fibroblasts, vascular cells, and extracellular elements, such as the extracellular matrix (ECM). Many components of the stroma initially exert an anti-tumor effect, but over time, they undergo functional transformation into elements that promote tumor growth. As a result, conditions conducive to further cancer development, invasion into local tissues, and distant metastasis arise. The microenvironment of colorectal cancer (CRC) may be an important direction in the search for therapeutic targets, but it requires further understanding. The main purpose of our review is to explain the role of the complex CRC microenvironment in the progression of this cancer and highlight the potential of targeted therapy directed at the TME. Therefore, continued research into its components and typical biomarkers is necessary to improve therapy and enhance the quality of life for patients. Full article
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