Internal and/or External Radiotherapy and Dosimetric Evaluation: From Cellular Level to the Patient

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 20 July 2024 | Viewed by 1466

Special Issue Editors

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Guest Editor
MedicalPhysics Unit, IRCCS IstitutoRomagnolo per lo Studio deiTumori (IRST) “Dino Amadori”, 47014 Meldola, Italy
Interests: medical physics; dosimetry; radiation therapy; radiobiology; radiotherapy; cytotoxicity; raman spectroscopy; radioactivity

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Guest Editor
Department of Medical Physics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy
Interests: radiotherapy; nuclear medicine; dosimetry and radiobiology
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Special Issue Information

Dear Colleagues,

We are inviting submissions to the Special Issue on "Internal and/or External Radiotherapy and Dosimetric Evaluation: From Cellular Level to the Patient", which aims to cover the recent outstanding developments of radiotherapy and nuclear medicine treatments.  

Radiotherapy and nuclear medicine have a central role in the multidisciplinary field of oncology, either considered individually as possible way to irradiate tumors in combination with other modalities of treatment or in a combination of internal and external radiotherapy.

In recent years, both have experienced great improvements and developments, such as the increased number of particle therapy facilities worldwide; the concept of "theranostic"; a deeper understanding of tumor biology; improvements in imaging (together with radiomics and deep learning methods) from diagnosis and staging passing through treatment and finally to follow-up.

Although these are some of the goals achieved, the answers to questions ranging from the cellular level down to the patient remain opened. Some examples are: the possibility of using spectroscopy investigations to study cancer cell radioresistance; the basis to trigger a certain type of cell death after ionizing radiation treatment; the precise dosimetry evaluation of the treatment performed; dosimetric and radiobiological impact related to the treatment schedule with the possibility of a less toxic effect to normal tissues or improved tumor control/survival.

In this Special Issue, we invite you to contribute with original research articles exploring application of radiotherapy and/or nuclear medicine therapy on cell cultures and/or patients. Theoretical and experimental studies are welcome for submission, as well as are comprehensive reviews and editorials.

Potential topics include, but are not limited to:

  • Basic research on cell cultures exposed to ionizing radiation;
  • Spectroscopic investigation on cell cultures exposed to ionizing radiation;
  • Dosimetry and radiobiological study at the cellular and/or animal level;
  • Radiobiology analysis of in vitro assays with tumor cell lines and in animal models of cancer;
  • Diagnostic nuclear medicine (PET, SPECT, and hybrid imaging);
  • Quantitative imaging;
  • Advances in nuclear medicine dosimetry;
  • Therapeutic nuclear medicine;
  • Advances in radiotherapy planning and delivery;
  • Basic research in radiotherapy;
  • Pre-treatment and/or in vivo dosimetric evaluation of ionizing radiation treatments or online dosimetry;
  • Software and instruments for dose assessment;
  • Radiomics;
  • Predictive models.

Dr. Emilio Mezzenga
Dr. Lidia Strigari
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cell research
  • animal research
  • cancer cells
  • spectroscopy
  • Raman spectroscopy
  • FT-IR spectroscopy
  • radiotherapy
  • particle therapy
  • molecular radiotherapy
  • radiobiology
  • dosimetry
  • radiomics

Published Papers (1 paper)

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12 pages, 2313 KiB  
The Role of Lung Density in the Voxel-Based Dosimetry of 90Y-TARE Evaluated with the Voxel S-Value (VSV) Method and Fast Monte Carlo Simulation
by Amedeo Capotosti, Roberto Moretti, Maria Vaccaro, Cintia De Almeida Ribeiro, Lorenzo Placidi, Matteo Nardini, Guenda Meffe, Davide Cusumano, Luca Zagaria, Marina De Risi, Germano Perotti, Lucia Leccisotti, Marco De Spirito, Roberto Iezzi and Luca Indovina
Appl. Sci. 2024, 14(3), 1019; - 25 Jan 2024
Viewed by 952
(1) Background: In 90Y-TARE treatments, lung-absorbed doses should be calculated according to the manufacturer’s instructions, using the MIRD-scheme. This scheme is derived from the assumption that 90Y-microspheres deliver the dose in a water-equivalent medium. Since the density of the lungs is [...] Read more.
(1) Background: In 90Y-TARE treatments, lung-absorbed doses should be calculated according to the manufacturer’s instructions, using the MIRD-scheme. This scheme is derived from the assumption that 90Y-microspheres deliver the dose in a water-equivalent medium. Since the density of the lungs is quite different from that of the liver, the absorbed dose to the lungs could vary considerably, especially at the liver/lungs interface. The aim of this work is to compare the dosimetric results obtained by two dedicated software packages implementing a water-equivalent dose calculation and a Monte Carlo (MC) simulation, respectively. (2) Methods: An anthropomorphic IEC phantom and a retrospective selection of 24 patients with a diagnosis of HCC were taken into account. In the phantom study, starting from a 90Y-PET/CT acquisition, the liver cavity was manually fixed with a uniform activity concentration on PET series, while the lung compartment was manually expanded on a CT series to simulate a realistic situation in which the liver and lungs are adjacent. These steps were performed by using MIM 90Y SurePlan. Then, a first simulation was carried out with only the liver cavity filled, while a second one was carried out, in which the lung compartment was also manually fixed with a uniform activity concentration corresponding to 10% lung shunt fraction. MIM 90Y SurePlan was used to obtain Voxel S-Value (VSV) approach dose values; instead, Torch was used to obtain MC approach dose values for both the phantom and the patients. (3) Results: In the phantom study, the percentage mean dose differences (∆D%) between VSV and MC in the first and second simulation, respectively were found to be 1.2 and 0.5% (absolute dose variation, ∆D, of 0.7 and 0.3 Gy) for the liver, −56 and 70% (∆D of −0.3 and −16.2 Gy) for the lungs, and −48 and −60% (∆D of −4.3 and −16.5 Gy) for the Liver/Lungs Edge region. The patient study reports similar results with ∆D% between VSV and MC of 7.0%, 4.1% and 6.7% for the whole liver, healthy liver, and tumor, respectively, while the result was −61.2% for the left lung and −61.1% for both the right lung and lungs. (4) Conclusion: Both VSV and MC allowed accurate radiation dose estimation with small differences (<7%) in regions of uniform water-equivalent density (i.e., within the liver). Larger differences between the two methods (>50%) were observed for air-equivalent regions in the phantom simulation and the patient study. Full article
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