Biological Activity and Applications of Natural Plant Compounds

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Food Science and Technology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 649

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Science, Faculty of Pharmacy, “Vasile Goldis” Western University of Arad, 86 Liviu Rebreanu Street, 310045 Arad, Romania
Interests: natural products; quercetin; supplements; biochemistry; functional foods; environmental chemistry

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Guest Editor
Department of Clinical Laboratory and Food Safety, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania
Interests: antioxidant action; hydroalcoholic plant extracts; oxidative stress; polyphenols; medical nutrition; phytochemicals

Special Issue Information

Dear Colleagues,

Plants are a huge source of chemical compounds. Flavonoids, anthocyanins, tannins, and carotenoids represent some of the better known natural compounds.

The biological activity of natural plant compounds is expressed through their actions on the human body. Among the most important effects, we list antioxidant, anti-inflammatory, antimicrobial, antitumor, immunomodulatory, neuroprotective, antihypertensive and antidiabetic activity.

This Special Issue of Applied Sciences entitled “Biological Activity and Applications of Natural Plant Compounds” highlights the importance of the activity of natural plant compounds and the diversity of their pharmacological activities.

Dr. Melania Florina Munteanu
Dr. Elena Moroșan
Guest Editors

Manuscript Submission Information

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Keywords

  • plants
  • compounds
  • biological activity
  • antioxidant
  • anti-inflammatory
  • antimicrobial
  • antitumor
  • immunomodulatory
  • neuroprotective
  • antihypertensive and antidiabetic activity
  • flavonoids
  • anthocyanins
  • tannins
  • carotenoids

Published Papers (1 paper)

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Research

13 pages, 12571 KiB  
Article
Protective Effects of Hesperetin on Cardiomyocyte Integrity and Cytoskeletal Stability in a Murine Model of Epirubicin-Induced Cardiotoxicity: A Histopathological Study
by Adina Pop Moldovan, Simona Dumitra, Cristina Popescu, Radu Lala, Nicoleta Zurbau Anghel, Daniel Nisulescu, Ariana Nicoras, Coralia Cotoraci, Monica Puticiu, Anca Hermenean and Daniela Teodora Marti
Appl. Sci. 2024, 14(6), 2560; https://doi.org/10.3390/app14062560 - 19 Mar 2024
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Abstract
Anthracyclines, including epirubicin (Epi), are effective chemotherapeutics but are known for their cardiotoxic side effects, primarily inducing cardiomyocyte apoptosis. This study investigates the protective role of hesperetin (HSP) against cardiomyopathy triggered by Epi in a murine model. Male CD1 mice were divided into [...] Read more.
Anthracyclines, including epirubicin (Epi), are effective chemotherapeutics but are known for their cardiotoxic side effects, primarily inducing cardiomyocyte apoptosis. This study investigates the protective role of hesperetin (HSP) against cardiomyopathy triggered by Epi in a murine model. Male CD1 mice were divided into four groups, with the Epi group receiving a cumulative dose of 12 mg/kg intraperitoneally, reflecting a clinically relevant dosage. The co-treatment group received 100 mg/kg of HSP daily for 13 days. After the treatment period, mice were euthanized, and heart tissues were collected for histopathological, immunofluorescence/immunohistochemistry, and transmission electron microscopy (TEM) analyses. Histologically, Epi treatment led to cytoplasmic vacuolization, myofibril loss, and fiber disarray, while co-treatment with HSP preserved cardiac structure. Immunofluorescent analysis of Bcl-2 family proteins revealed Epi-induced upregulation of the pro-apoptotic protein Bax and a decrease in anti-apoptotic Bcl-2, which HSP treatment reversed. TEM observations confirmed the preservation of mitochondrial ultrastructure with HSP treatment. Moreover, in situ detection of DNA fragmentation highlighted a decrease in apoptotic nuclei with HSP treatment. In conclusion, HSP demonstrates a protective effect against Epi-induced cardiac injury and apoptosis, suggesting its potential as an adjunctive therapy in anthracycline-induced cardiomyopathy. Further studies, including chronic cardiotoxicity models and clinical trials, are warranted to optimize its therapeutic application in Epi-related cardiac dysfunction. Full article
(This article belongs to the Special Issue Biological Activity and Applications of Natural Plant Compounds)
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