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Antioxidants
Special Issues
Bioenergetic in Mitochondria and Reactive Oxygen Species Production in Domestic...
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Bioenergetic in Mitochondria and Reactive Oxygen Species Production in Domestic Animals

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "ROS, RNS and RSS".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 2044

Special Issue Editor

Dr. Motoi Kikusato

E-Mail Website
Guest Editor
Animal Nutrition, Life Sciences, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza-Aoba, Aoba-ku, Sendai 980-8572, Japan
Interests: mitochondria; phytochemicals; intestinal/systemic inflammation; protein metabolism; metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Mitochondria are the power plants of the cells and have an important role in cell energetic homeostasis. The organelle also generates reactive oxygen species as a byproduct of anerobic metabolism, which affects cell physiology, metabolism, immunity, etc. The study of mitochondria in domestic animals has evolved to understand the influences on phenotypes such as growth performance, stress resistance, and pathology. In this Special Issue, studies of mitochondrial functions, morphology/histochemistry and bioenergetics, but not genetics, in domestic animals’ tissues and cultured cells are welcomed.

Dr. Motoi Kikusato
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cell physiology
  • metabolism
  • inflammation
  • stress
  • pathology
  • chicken
  • pig
  • cow/cattle

Published Papers (1 paper)

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Research

20 pages, 2353 KiB  
Article
Polydatin Attenuates Intra-Uterine Growth Retardation-Induced Liver Injury and Mitochondrial Dysfunction in Weanling Piglets by Improving Energy Metabolism and Redox Balance
by Yanan Chen, Yue Li, Peilu Jia, Shuli Ji, Hao Zhang and Tian Wang
Antioxidants 2022, 11(4), 666; https://doi.org/10.3390/antiox11040666 - 30 Mar 2022
Cited by 1 | Viewed by 1602
Abstract
The present study investigated the potential of polydatin to protect against liver injury and the mitochondrial dysfunction of weanling piglets suffering from intra-uterine growth retardation (IUGR). Thirty-six normal birth weight weanling piglets and an equal number of IUGR littermates were given a basal [...] Read more.
The present study investigated the potential of polydatin to protect against liver injury and the mitochondrial dysfunction of weanling piglets suffering from intra-uterine growth retardation (IUGR). Thirty-six normal birth weight weanling piglets and an equal number of IUGR littermates were given a basal diet with or without polydatin (250 mg/kg) from 21 to 35 d of age. Plasma and liver samples were collected to measure biochemistry parameters at 35 d of age. IUGR caused hepatic apoptosis, mitochondrial dysfunction, and oxidative damage, along with a lower efficiency of energy metabolism and inferior antioxidant ability. Polydatin decreased apoptotic rate, improved the features of mitochondrial damage, inhibited mitochondrial swelling and superoxide anion formation, and preserved mitochondrial membrane potential in the liver. Concurrently, polydatin promoted mitochondrial biogenesis, increased sirtuin 1 activity, and upregulated the expression levels of several genes related to mitochondrial function and fitness. Polydatin also facilitated mitochondrial oxidative metabolism with a beneficial outcome of increased energy production. Furthermore, polydatin mitigated the IUGR-induced reduction in manganese superoxide dismutase activity and prevented the excessive accumulation of oxidative damaging products in the liver. These findings indicate that polydatin confers protection against hepatic injury and mitochondrial dysfunction in the IUGR piglets by improving energy metabolism and redox balance. Full article
(This article belongs to the Special Issue Bioenergetic in Mitochondria and Reactive Oxygen Species Production in Domestic Animals)
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