Dear Colleagues,

Postprandial oxidative stress (POS) is characterized by an increased susceptibility of the organism towards oxidative damage after consumption mainly of a meal rich in lipids. POS is mainly affected by advanced lipid oxidation end products (ALEs), high lipid diet (HLD), or by diets containing both ALEs and high-lipid constituents. The gastrointestinal tract (GIT) provides an excellent medium for lipid peroxidation and co-oxidation of dietary constituents such as proteins, cholesterol, and vitamins through the generation of ALEs including reactive carbonyls, oxy-cholesterols, and many other by-products. These ALEs and by-products are, in part, absorbed through the enterocyte into the blood system and generate POS, affecting many organs. Chronic exposures of the GIT and other organs to ALEs through activation of RAGE and cholesterol receptors, as well as through activation of NADPH-oxidase-H₂O₂/NFkB/axis, induce a high risk of developing POS; gastrointestinal, cardiovascular, kidney, and neurodegenerative diseases; diabetes; and the same kinds of cancers. Many epidemiologic and experimental studies have provided significant data regarding the beneficial effects of regular consumption of plant foods associated with polyphenol content on POS and human health. There are health benefits of consuming polyphenols’ molecules in the diet, derived mainly from their common activities in the gastrointestinal tract at high concentrations, as antioxidants prevent the generation of reactive carbonyls, and at the level of the blood system, as they are generators of low concentrations of H₂O₂, thus activating the signalling factor Nrf2/axis/ of cell adaptation to oxidative stress. I hypothesize that ingestion of polyphenols at the right amount and time during a meal acts synergistically at the level of the gastrointestinal tract (GIT) and blood system to maintain the redox homeostasis in our body and better balance human health.

I invite you to submit your latest research or review article to this Special Issue. Manuscripts may be related to this subject based on the scientific areas of chemistry, biochemistry, molecular biology, clinical nutrition, or nutrigenomics, or focused on POS/antioxidant effects on GIT and other organs.

Prof. Dr. Joseph Kanner
Guest Editor

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• postprandial oxidative stress
• prooxidants
• antioxidants
• gastrointestinal tract
• organs