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Journals
Antioxidants
Special Issues
Oxidative Stress and Environmental Toxicology
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Oxidative Stress and Environmental Toxicology

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 20 July 2024 | Viewed by 1527

Special Issue Editor

Dr. Ken-ichiro Tanaka

E-Mail Website
Guest Editor
Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, Nishitokyo 2028585, Japan
Interests: air pollution; metallothionein; oxidative stress; fibroblasts; idiopathic pulmonary fibrosis

Special Issue Information

Dear Colleagues,

Humans are exposed to air pollutants such as fine particulate matter (PM2.5), toxic metals such as cadmium and arsenic, and pesticides in the environment, and in many cases, these induce health problems. In addition, these toxic substances induce the excessive production of reactive oxygen species (ROS) through their own properties as radicals or by acting on our human tissues and cells. For example, it has been confirmed in cellular and animal experiments as well as clinical studies that air pollutants such as PM2.5 induce excessive ROS production, which in turn induces lung injury and cardiovascular damage. Therefore, discovering the detailed mechanisms of oxidative stress induced by toxic substances and how to prevent it is a critical issue for maintaining our health.

As Guest Editor, I invite you to contribute to the Special Issue on “Oxidative Stress and Environmental Toxicology”. Original articles and reviews will be published online in Antioxidants.

Dr. Ken-ichiro Tanaka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • air pollutants
  • toxic metals
  • environmental toxicology
  • ROS

Published Papers (1 paper)

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Review

27 pages, 817 KiB  
Review
Nitrooxidative Stress and Neuroinflammation Caused by Air Pollutants Are Associated with the Biological Markers of Neurodegenerative Diseases
by Abraham Alberto Ramírez-Mendoza, María Luisa Mendoza-Magaña, Mario Alberto Ramírez-Herrera, Zamira Helena Hernández-Nazara and José Alfredo Domínguez-Rosales
Antioxidants 2024, 13(3), 326; https://doi.org/10.3390/antiox13030326 - 07 Mar 2024
Viewed by 1196
Abstract
Millions of people around the world are exposed to air pollutants, such as particulate matter 2.5 (PM2.5) and ozone (O3). Such exposure usually does not exclude these two types of pollutants and their harmful effects could be additive or [...] Read more.
Millions of people around the world are exposed to air pollutants, such as particulate matter 2.5 (PM2.5) and ozone (O3). Such exposure usually does not exclude these two types of pollutants and their harmful effects could be additive or synergistic. O3 is a highly oxidizing gas that reacts with the cellular environment just as PM2.5, triggering nitrooxidative damage. Once nitrooxidative stress overcomes the endogenous antioxidant system, an acute neuroinflammatory process is generated, and once it becomes chronic, it favors the formation of neurodegenerative disease markers. The presence of these markers becomes potentially dangerous in people who have a genetic predisposition and are at a higher risk of developing neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Our experimental approach for nitrooxidative damage and neuroinflammation caused by air pollutants has focused on the exposure of rats to O3 in an isolated chamber. The hippocampus is the most studied brain structure because of its neuronal connectivity network with the olfactory epithelium, its weak antioxidant defense, and its fundamental roll in cognitive processes. However, other brain structures may exhibit a different degree of damage upon exposure to O3 and PM2.5, making their involvement an important factor in developing other CNS diseases. The age spectrum for augmented sensibility to air pollutants seems to mostly affect the pre-postnatal (autism spectrum) period and the elderly (neurodegenerative). Thus, a new approach could be the estimation of the damage caused by PM2.5 and O3 through a controlled exposure paradigm to determine the extent of damage caused by both pollutants. Full article
(This article belongs to the Special Issue Oxidative Stress and Environmental Toxicology)
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