ROS-Mediated Transition From Adaptation to Maladaptation in Myocardial Remodeling: Points of Convergence and Divergence
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "ROS, RNS and RSS".
Deadline for manuscript submissions: closed (10 December 2023) | Viewed by 1420
Special Issue Editor
Special Issue Information
Dear Colleagues,
Myocardial remodeling is a response of cardiac muscle to the stressful influence and injury caused by a large number of physiological and pathological conditions. Initially, it was considered a beneficial mechanism. However, sustained and prolonged cardiac remodeling has been associated with a significant increase in the risk of cardiovascular disease and mortality. There is growing evidence that oxidative stress, defined as an excess production of reactive oxygen species (ROS) relative to antioxidant defense, plays a central role in the pathophysiology of cardiac remodeling processes. It dictates subtle changes in intracellular pathways and redox signaling at lower levels, but causes cellular dysfunction, abnormal metabolism and damage at higher levels. Many researchers are trying to understand whether ROS-mediated cardiac remodeling is a “good” response to adaptation or a “bad” process to maladaptation.
This Topic aims to increase knowledge and understanding of physio(patho)logical nature of cardiac remodeling processes linked to oxidative stress status.
Dr. Oksana Kunduzova
Guest Editor
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Keywords
- ROS
- oxidative stress
- injury
- environmental stresses
- cardiac remodeling
- metabolism
- antioxidants
- OXPHOS
- heart
