Methodologies for Improving Antioxidant Properties and Absorption

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1374

Special Issue Editor


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Guest Editor
Department of Science, “Roma Tre” University, 00146 Rome, Italy
Interests: organic chemistry; antioxidants; natural compound synthesis; antioxidant activity

Special Issue Information

Dear Colleagues,

The beneficial effects of an antioxidant are determined not only by its radical scavenging capacity, but also by its absorption profile and bioavailability, which allows the molecule to reach the target cell or to prevent the long-term oxidation of compounds used in biology, medicine or food, and in the cosmetic industry.

Various systems have been explored to enhance the absorption and/or bioavailability of natural antioxidants: (a) modifications of the structure of the molecule, to enhance its solubility, activity, or stability; and (b) the use of “delivery” systems (nanocarriers, liposomes, etc.) which facilitate transport to the target.

We invite you to submit your latest research findings or a review article to this Special Issue, which will bring together current research regarding the effect of antioxidant structure modifications on antioxidant activity and the results of new carrier systems in enhancing antioxidant transport, cell targeting, and absorption.

This research can include both in vitro and in vivo studies, relating to any of the following topics: (i) the structure/antioxidant activity of modified natural or synthetic antioxidants, or (ii) the role of carrier systems in the enhancement and/or specificity of cell/tissue/organ absorption of the target antioxidant molecule.

We look forward to receiving your contribution.

Dr. Daniela Tofani
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • modified antioxidant synthesis
  • antioxidants activity/capacity
  • antioxidant adsorption
  • nanocarriers
  • liposomes
  • transport systems
  • antioxidant polymers

Published Papers (1 paper)

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Research

16 pages, 4025 KiB  
Article
Inclusion of a Catechol-Derived Hydrazinyl-Thiazole (CHT) in β-Cyclodextrin Nanocavity and Its Effect on Antioxidant Activity: A Calorimetric, Spectroscopic and Molecular Docking Approach
by Mihaela Mic, Adrian Pîrnău, Călin G. Floare, Mariana Doina Palage, Ovidiu Oniga and Gabriel Marc
Antioxidants 2023, 12(7), 1367; https://doi.org/10.3390/antiox12071367 - 29 Jun 2023
Cited by 2 | Viewed by 1007
Abstract
The aim of the present research was to obtain a supramolecular complex between a strong antioxidant compound previously reported by our group, in order to extend its antioxidant activity. The formation of the inclusion complex of a catechol hydrazinyl-thiazole derivative (CHT) and β-cyclodextrin [...] Read more.
The aim of the present research was to obtain a supramolecular complex between a strong antioxidant compound previously reported by our group, in order to extend its antioxidant activity. The formation of the inclusion complex of a catechol hydrazinyl-thiazole derivative (CHT) and β-cyclodextrin in aqueous solution has been investigated using isothermal titration calorimetry (ITC), spectroscopic and theoretical methods. The stoichiometry of this inclusion complex was established to be equimolar (1:1) and its equilibrium constant was determined. An estimation of the thermodynamic parameters of the inclusion complex showed that it is an enthalpy and entropy-driven process. Our observations also show that hydrophobic interactions are the key interactions that prevail in the complex. 1H NMR spectroscopic method was employed to study the inclusion process in an aqueous solution. Job plots derived from the 1H NMR spectral data demonstrated 1:1 stoichiometry of the inclusion complex in a liquid state. A 2D NMR spectrum suggests the orientation of the aromatic ring of CHT inside the β-CD cavity. The antiradical activity of the complex was evaluated and compared with free CHT, indicating a delayed activity compared with free CHT. To obtain additional qualitative and visual insight into the particularity of CHT and β-CD interaction, molecular docking calculations have been performed. Full article
(This article belongs to the Special Issue Methodologies for Improving Antioxidant Properties and Absorption)
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