Redox-Dependent Regulation of Haemostasis in Health and Disease
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 10488
Special Issue Editor
Special Issue Information
Dear Colleagues,
Haemostasis is the homeostatic response of the human body to injury and bleeding. Haemostasis is typically divided into primary haemostasis, in which circulating platelets play a pivotal role, and secondary haemostasis, consisting of the activation of the coagulation cascade leading to fibrin deposition and ultimately blood clotting. The distinction between primary and secondary haemostasis is only conceptual. In reality, these two responses are tightly entwined, with platelets promoting coagulation and coagulation activating platelets via thrombin. Canonical post-translational protein modifications regulate both platelets and coagulation, with protein phosphorylation central to platelet function and proteolytic activation of native zymogens pivotal for coagulation. In addition, a growing body of evidence suggests that oxidative post-translational modification of plasma proteins, blood cells and vascular tissues is involved in normal primary and secondary haemostasis in physiological conditions. Interestingly, oxidative stress leads to the dysregulation of protein oxidation in the circulatory system, which participates in the development of the thrombotic complications associated with human vascular diseases. In this collection, we aim to present our current understanding of how oxidant molecules and the enzyme responsible for their generation control the human vascular system both in health and disease.
Dr. Giordano Pula
Guest Editor
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Keywords
- haemostasis
- platelet
- coagulation
- endothelial
- thrombosis
- oxidative stress
- oxidant
- redox
