Dear Colleagues,

Many studies have illustrated the role of oxidative stress in mediating hypertension associated with various pathologies, including obesity, chronic kidney disease, diabetes, and preeclampsia. Oxidative stress is defined as an imbalance between prooxidants and antioxidants, resulting in an excessive production of reactive oxygen species (ROS). ROS include superoxide anion radical, hydrogen peroxide, hydroxyl radical, peroxynitrite, and lipid radicals. Imbalanced ROS generation/elimination can cause structural and physiological damage to DNA, RNA, proteins, and lipids, thereby contributing to inflammation, endothelial dysfunction, vascular injury, and tissue damage associated with hypertension. Furthermore, high levels of ROS can reduce the bioavailability of nitric oxide, a key factor in maintaining the vascular tone.

We encourage you to contribute your latest research or review to this Special Issue, which aims to compile the latest advances in the understanding of the relationship between oxidative stress and hypertension, as well as their potential for designing and evaluating novel antihypertensive therapies. This can include studies relating to any of the following topics:  the molecular mechanisms of vascular dysfunction in essential hypertension or associated with other pathologies; oxidative stress addressed through genetic and epigenetic approaches (histone acetylation/methylation, DNA methylation, regulation of microRNA); development of new strategies such as physical training and therapeutics targeting eNOS with oxidative impairment or soluble guanylate cyclase; the delivery of antioxidants directly to the endothelium through specific ligands or through vectors.

We look forward your contribution.

Dr. Isabel Hernández
Dr. María Teresa Llinas Más
Guest Editors

Manuscript Submission Information

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• oxidative stress
• nitric oxide
• hypertension
• endothelial function
• epigenetic