Mitochondrial Oxidative Metabolism in Heart and Muscle
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 1284
Special Issue Editor
Special Issue Information
Dear Colleagues,
Beyond their well-known role in ATP production, mitochondria take part in many cellular processes, such as apoptosis, ion homeostasis, thermogenesis, and production of radical oxygen species (ROS). In cardiac muscle cells and skeletal muscle slow twitch fibers, mitochondria are the main energy producers and occupy a large volume of intracellular medium. Consequently, these myocytes are particularly exposed to mitochondrial ROS, which are inevitably produced when the mitochondrial electron transfer chain is working. While low production of ROS is an essential intracellular signal and participates in cellular homeostasis in cells with an appropriate antioxidant defense system, dysregulation of ROS production and/or degradation leads to oxidative stress, which can be a key element in the pathophysiology of cardiac and muscular diseases. This Special Issue focuses on recent research advances made to better understand mitochondrial oxidative metabolism in heart and skeletal muscle in physiology and pathophysiology and how this could be impacted by potential antioxidant compounds. We warmly welcome the submission of original papers and reviews addressing these topics.
Dr. Jérôme Piquereau
Guest Editor
Manuscript Submission Information
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Keywords
- mitochondrion
- oxidative stress
- heart
- skeletal muscle
- cardiac disease
- myopathy
