Dear Colleagues,

The ageing process is associated with a loss of neuronal function that leads to neurodegeneration. The main cellular alteration is linked with a decline in mitochondrial function and increased oxidative stress. Normal and pathological ageing depend on the response of the repair mechanisms of the cells at the multisystemic level. These mechanisms aim to refresh the cells in order to maintain normal function. Activation of opposing cellular pathways such as autophagy or neurogenesis can prolong healthy ageing and the lifespan. For this Special Issue, we want researchers to submit original research articles and review articles about the role of neuronal function in age-related physiological states and diseases, as well as about recent findings on the neuroprotective mechanisms that stop neuronal loss and control neurorecovery in the elderly. To help bridge the current knowledge gap, this Special Issue includes, but is not limited to, age-related diseases of the central and peripheral nervous system, chronic inflammatory diseases such as multiple sclerosis, ankylosing spondylitis, amyotrophic lateral sclerosis, rheumatoid arthritis, or frailty, as well as healthy ageing. Submissions may address a broad range of topics, including but not limited to the therapeutic potential of bioactive compounds, physical exercise, nutrition, nutriomics, metabolomics, epigenetics, personalized nutrition, oxidative stress, antioxidants, autophagy, nanotechnology, neurodegeneration, and neuroregeneration. We are also interested in research that examines the effects of nutraceuticals or pharmaceuticals related to pharmacokinetics, pharmacodynamics, bioavailability, and efficacy. These may be in vitro or in vivo studies, studies on humans or clinical trials, and dietary intervention studies evaluating impacts on health and diseases or required intake and usage dosage.

We look forward to your submissions.

Dr. Ana-Maria Buga
Dr. Carmen Nicoleta Oancea
Guest Editors

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• ageing
• nutrition
• physical exercise
• oxidative stress
• antioxidants
• autophagy
• fragility
• neurodegeneration
• inflammation
• nutrigenomics
• nanotechnology