The Interplay of Oxidative Stress, the Gut–Brain Axis, and Neurodegenerative Diseases
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 May 2024 | Viewed by 830
Special Issue Editor
Interests: redox signaling; inflammation; hormesis; vitagenes; polyphenols
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The antioxidant and anti-inflammatory effects of polyphenols for enhancing human stress resilience in health and disease have received more attention. Recently, the gut–brain axis (GBA) has gained attention for preventing and therapeutically impacting neuropathologies and gastrointestinal diseases. Polyphenols and polyphenol-combined nanoparticles in synergy with probiotics are shown to improve their gut bioavailability and blood–brain barrier (BBB) permeability, thus inhibiting oxidative stress, metabolic dysfunction, and inflammation linked to gut dysbiosis and the consequent onset and progression of nervous system disorders. According to hormesis, nutrients exhibit biphasic dose–response effects, activating low-dose antioxidant signaling pathways, as in the case of the Nrf2 pathway upregulated by hydroxytyrosol or curcumin and NAD/NADH-sirtuin-1 activated by resveratrol to block ROS production, microbiota dysfunction, and neurotoxic damage. Importantly, modulating the composition and function of gut microbiota through polyphenols increases the abundance of beneficial bacteria and can prevent and treat Alzheimer’s disease and also other neurological disorders. The Special Issue mainly focuses on oxidative stress and the role of hormetic nutrients by summarizing their neuroprotective and anti-inflammatory properties as well as pharmacological interventions in gut–brain disorders.
Dr. Maria Concetta Scuto
Guest Editor
Manuscript Submission Information
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Keywords
- oxidative stress
- hormetic nutrients
- natural antioxidants
- neurodegenerative disorders
- gut–brain axis
