The Role of Nutrition and Exercise in the Prevention and Treatment of Oxidative Stress-Associated Diseases

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 1594

Special Issue Editors


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Guest Editor
1. Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany
2. Hector-Center for Nutrition, Exercise and Sports, Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany
3. German Center Immunotherapy (DZI), University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany
Interests: exercise; sport physiology; muscle physiology; chronic diseases; nutrition

E-Mail Website
Guest Editor
1. Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany
2. Hector-Center for Nutrition, Exercise and Sports, Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany
3. German Center Immunotherapy (DZI), University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany
Interests: cachexia syndrome; malnutrition; muscle function; atrophy and therapy; food intolerance and food allergy; celiac disease and non-celiac gluten sensitivity; chronic inflammatory bowel disease
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany
2. Hector-Center for Nutrition, Exercise and Sports, Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany
3. German Center Immunotherapy (DZI), University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany
Interests: nutrition; exercise; sport physiology; muscle physiology; metabolic syndrome; gastrointestinal diseases

Special Issue Information

Dear Colleagues,

Over the last decades, non-communicable chronic diseases (NCDs) have been dramatically increasing in their prevalence and constitute the most common causes of death around the globe. Therefore, the exploration and development of effective measures to prevent and control NCDs have become an important public health issue. Many of the most common chronic diseases, such as cardiovascular disease, type 2 diabetes and cancer, are associated with increased inflammation and oxidative stress. In this context, it is well accepted that lifestyle habits, including nutrition and physical activity, play a key role in the prevention of chronic conditions. Moreover, nutritional modifications and targeted exercise interventions are crucial cornerstones in NCD treatment. It has been shown, for example, that a good level of cardiorespiratory fitness is associated with a better overall health status and a reduced risk of mortality in apparently healthy individuals, as well as in clinical populations. In addition, both a proper diet and regular exercise and can help reduce medication needs and improve the quality of life in patients with a variety of chronic issues.

The goal of this Special Issue is to provide an updated overview and new knowledge on the role of nutrition, physical activity and exercise in the prevention and treatment of oxidative stress-related NCDs. Both original research and review papers are welcome for article collection. Authors are invited to submit the findings of their recent investigations relating the effects of diet, nutritional supplements, physical activity or exercise on oxidative stress, inflammation and associated outcomes in chronic conditions, particular (but not limited to) cardiometabolic diseases and cancer. We aim to present new discoveries in the field and to stimulate a fruitful discussion of innovative approaches to prevent and treat NCDs with nutrition and exercise.

Prof. Dr. Dejan Reljic
Prof. Dr. Yurdagül Zopf
Dr. Hans Joachim Herrmann
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • physical activity
  • exercise
  • oxidative stress
  • chronic diseases
  • cardiovascular disease
  • type 2 diabetes
  • cancer
  • inflammation

Published Papers (2 papers)

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Research

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13 pages, 304 KiB  
Article
Effects of Regular Exercise on the Biochemical, Oxidative, and Inflammatory Profiles and Quality of Life in Older Spaniards with Metabolic Syndrome
by Margalida Monserrat-Mesquida, Maria Magdalena Quetglas-Llabrés, Cristina Bouzas, Silvia García, David Mateos, Lucía Ugarriza, Cristina Gómez, Josep A. Tur and Antoni Sureda
Antioxidants 2024, 13(4), 450; https://doi.org/10.3390/antiox13040450 - 11 Apr 2024
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Abstract
Metabolic syndrome increases the risk of developing diabetes and cardiovascular disease. The regular practice of physical activity is a crucial factor for healthy aging and for controlling and preventing chronic diseases. To assess the effects of regular physical activity on the biochemical and [...] Read more.
Metabolic syndrome increases the risk of developing diabetes and cardiovascular disease. The regular practice of physical activity is a crucial factor for healthy aging and for controlling and preventing chronic diseases. To assess the effects of regular physical activity on the biochemical and inflammatory profiles, as well as the quality of life of older adults diagnosed with metabolic syndrome. Participants (aged 55–70 years; living in the Balearic Islands, Spain) were divided into two groups (n = 50 each) according to the degree of physical activity measured by metabolic equivalents of task (METs). Anthropometric parameters, blood pressure, biochemical and hematological parameters, and inflammatory biomarkers were measured. Beck Depression Inventory and adherence to the Mediterranean diet questionnaires, as well as the Dietary Inflammatory Index, chair test, health-related quality of life (HRQoL), and Rapid Assessment of Physical Activity, were also determined. The characterization of the patients was similar in both groups, showing a homogeneous sample. The group with the highest METs experienced a decrease in depression and an increase in the intensity of physical activity. Adherence to the Mediterranean diet and HRQoL physical dimensions increased in participants with the highest METs, also showing a decrease in glycemia and glycosylated hemoglobin values. Inflammatory biomarkers, including tumor necrosis factor alpha, interleukin-6, interleukin-1β, and osteoprotegerin, decreased in patients practicing more physical activity. High levels of physical activity are related to a healthier lifestyle, characterized by high adherence to the Mediterranean diet, decreased depressive behavior, oxidative stress, and inflammatory status in older people with metabolic syndrome. Full article
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Review

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16 pages, 1061 KiB  
Review
The Role of the Myokine Irisin in the Protection and Carcinogenesis of the Gastrointestinal Tract
by Monika Pinkas and Tomasz Brzozowski
Antioxidants 2024, 13(4), 413; https://doi.org/10.3390/antiox13040413 - 28 Mar 2024
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Abstract
Recently discovered irisin, a member of the myokines family, is a potential mediator of exercise-induced energy metabolism and a factor promoting browning of the white adipose tissue. Recent evidence indicates that this myokine, released from contracting muscles, can mediate the beneficial effects of [...] Read more.
Recently discovered irisin, a member of the myokines family, is a potential mediator of exercise-induced energy metabolism and a factor promoting browning of the white adipose tissue. Recent evidence indicates that this myokine, released from contracting muscles, can mediate the beneficial effects of exercise on health. Irisin may be a potential therapeutic agent against obesity and has been shown to play an important role in the protection of various cells, tissues, and organs due to its anti-inflammatory, antioxidative, and anti-cancer properties. Our aim was to review the recent experimental and clinical studies on irisin and its expression, release into the bloodstream, tissue targets, and potential contribution to the protective effects of exercise in the gastrointestinal tract. Particular emphasis was placed on inflammatory bowel disease, intestinal ischemia/reperfusion injury, periodontitis, and other digestive tract disorders, including carcinogenesis. Overall, irisin holds significant potential as a novel target molecule, offering a safe and therapeutic approach to treating various gastrointestinal diseases. Full article
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