Role of Super Oxide Dismutase (SOD)1 Isoenzyme and Reactive Oxygen Species (ROS) Generation in Cellular Pathophysiology

Dear Colleagues,

Intracellular Reactive Oxygen Species (ROS) have been recognised as key second messengers for a series of receptor/ligand interactions. Moreover, ROS involvement in the regulation of neuronal networks as well as of antigen-dependent T cell responses has been largely demonstrated.

ROS-dependent regulatory networks are usually mediated by peroxides. SOD enzymes physiologically mediate the scavenging of ROS to H₂O₂ and molecular oxygen. Particularly, SOD1 has been observed to interfere with multiple intracellular signalling networks, independently from its enzymatic activity. Indeed, SOD1/M1 muscarinic receptor interaction has been shown to mediate the activation of Protein Kinase C (PKC)-dependent signalling pathways and increase in intracellular Ca⁺⁺ level in excitable cells. Moreover, mTOR enzyme, a key molecule for differentiation of the Treg immune-modulating subset, has been described to regulate SOD1 activity.

A series of physiological inputs have been observed to mediate SOD-1 exocytosis, thus inducing increased interaction of the enzyme with a complex molecular network involved in the regulation of multiple biological processes. These findings add SOD to the molecules to be potentially targeted for innovative therapeutic approaches.

We invite you to submit your latest research findings or review/perspective articles to this Special Issue, which plans to bring together current research concerning SOD-dependent pathways in both physiological and pathological processes. We will welcome in vitro and in vivo studies related to SOD structure/function; the regulation of SOD production, intracellular localization and extracellular export; SOD posttranslational modifications; and the role of SOD in cell signalling, cell metabolism, cell cycle regulation, epigenetic pathway modulation, cellular stress managing and disease pathogenesis.

We look forward to your contribution.

Prof. Paolo Mondola
Dr. Giuseppina Ruggiero
Guest Editors

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• superoxide dismutase (SOD) isoenzymes
• superoxide dismutase (SOD)1
• cell signalling
• cell metabolism
• cell functions
• cellular stress
• disease pathogenesis