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Antioxidants
Special Issues
Mitochondrial Oxidative Stress and Inflammation
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Mitochondrial Oxidative Stress and Inflammation

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 1283

Special Issue Editor

Prof. Dr. Aldrin V. Gomes

E-Mail Website
Guest Editor
1. Department of Neurobiology, Physiology, and Behavior, University of California, One Shields Ave., Davis, CA 95616, USA
2. Department of Physiology and Membrane Biology, University of California, Davis, CA 95616, USA
Interests: antioxidants; cardiovascular diseases; mitochondrial metabolism; muscle contraction; proteasome; proteomics; reactive oxygen species

Special Issue Information

Dear Colleagues,

The main source of reactive oxygen species (ROS) responsible for oxidative stress in cells is mitochondrial respiration. When the excessive formation of ROS overwhelms the intrinsic antioxidant, a condition known as oxidative stress occurs. ROS can have damaging effects on proteins, lipids, and DNA, disrupting mitochondrial function and causing the subsequent development of various disease processes. Mitochondrial oxidative stress has been implicated in a wide variety of diseases including Alzheimer’s disease (AD), cardiovascular disease, and autoimmune type 1 diabetes. Research also suggests that mitochondria play an important role in pro-inflammatory signaling. Likewise, pro-inflammatory mediators may also alter mitochondrial function. Both processes increase mitochondrial oxidative stress, promoting an inflammatory cycle.

As Guest Editors, we invite you to contribute to this Special Issue, where the focus of which will be on the role of mitochondrial oxidative stress and/or inflammation in disease progression and during therapeutic interventions.

Prof. Dr. Aldrin V. Gomes
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • mitochondria
  • antioxidants
  • disease
  • inflammation
  • mitochondrial oxidative stress

Published Papers (1 paper)

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16 pages, 961 KiB  
Systematic Review
Oxidative Stress Mediated Therapy in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
by Katarina Djordjevic, Andjela Milojevic Samanovic, Mirjana Veselinovic, Vladimir Zivkovic, Victor Mikhaylovsky, Maria Mikerova, Vladimir Reshetnikov, Vladimir Jakovljevic and Tamara Nikolic Turnic
Antioxidants 2023, 12(11), 1938; https://doi.org/10.3390/antiox12111938 - 31 Oct 2023
Viewed by 977
Abstract
Objective: The aim of this meta-analysis is to explore all the available literature to obtain updated data about the potential use of antioxidants in the treatment of rheumatoid arthritis (RA) and its ability to reduce disease progression and cardiovascular risk. Methods: This systematic [...] Read more.
Objective: The aim of this meta-analysis is to explore all the available literature to obtain updated data about the potential use of antioxidants in the treatment of rheumatoid arthritis (RA) and its ability to reduce disease progression and cardiovascular risk. Methods: This systematic review and meta-analysis was performed strictly in accordance with the PRISMA guidelines. English and Chinese databases were searched with a retrieval time up to March 2023. These databases included the PubMed, Embase, Medline Complete, Web of Sciences and Cochrane Collaboration, Wanfang, China National Knowledge Infrastructure, and VIP databases. This literature search was formulated by the two researchers independently. The search strategy consists of reading, collecting the literature, and conducting the preliminary screening. After that, they provide the final selection of the literature according to the inclusion criteria and data extraction. Also, for all studies, the risk bias was assessed to evaluate the quality of the included references. The content of the risk assessment of bias included the following criteria: random allocation method, allocation plan hiding, blind method, completeness of result data, and selectivity of reporting of results, as well as other biases. The main outcomes were clinical efficiency of antioxidant therapy (C-reactive protein, DAS28 score, HAQ, Number of tender joints, etc.) and oxidative stress indicators (catalase, superoxide dismutase, or total antioxidant capacity). Results: We observed, in most of the studies, the small or moderate effects of antioxidant treatment. The mean effect size is 0.525, and that means that moderate effects were observed in 30 selected RCTs. Also, this effect is confirmed in the 1652 patients with RA with the mean confidence interval of 0.276 (lower limit) and 0.983 (upper limit). Cohen coefficient was calculated at 0.05. Conclusion: The existing evidence is that antioxidants can reduce systemic and local oxidative stress and can reduce damage as the main agent involved in autoimmune diseases such as rheumatoid arthritis. Full article
(This article belongs to the Special Issue Mitochondrial Oxidative Stress and Inflammation)
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