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Antioxidants
Special Issues
Significance of Antioxidant Mechanisms in Intestinal Inflammation
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Significance of Antioxidant Mechanisms in Intestinal Inflammation

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 6057

Special Issue Editors

Dr. Alba Rodríguez-Nogales

E-Mail Website
Guest Editor
Department of Pharmacology, Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain
Interests: antioxidant; immune response; inflammation; microbiota; polyphenols; prebiotics; probiotics
Special Issues, Collections and Topics in MDPI journals
Dr. María Elena Rodríguez Cabezas

E-Mail Website
Guest Editor
Department of Pharmacology, Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain
Interests: antioxidant; intestinal inflammation; microbiota; natural compounds; postbiotics; prebiotics; probiotics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antioxidant therapy has emerged as a potential approach to mitigate inflammation and oxidative damage in the gut. In the context of intestinal inflammation, antioxidants such as vitamins C and E, selenium, and natural polyphenols like curcumin and resveratrol have shown promise in reducing inflammation by reducing oxidative damage to intestinal cells. Although numerous experimental and clinical studies have demonstrated that antioxidants could modulate key pathways involved in inflammation, such as NF-κB and MAPK signalling, leading to the reduced production of pro-inflammatory cytokines, more studies are needed. A deeper understanding of the mechanisms involved in the generation of reactive oxygen species in intestinal inflammation, as well as their role and interaction with several treatments, will help us identify new targets and therapeutic strategies.

As Guest Editors, we invite you to contribute to this Special Issue, whose focus will be the role of oxidative stress in the initiation and progression of intestinal inflammation as well as during therapeutic interventions.

Dr. Alba Rodríguez-Nogales
Dr. María Elena Rodríguez Cabezas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant therapy
  • antioxidants
  • intestinal inflammation
  • oxidative stress
  • polyphenol
  • reactive oxygen/nitrogen species
  • redox homeostasis

Published Papers (3 papers)

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Research

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18 pages, 2767 KiB  
Article
The Antioxidant Properties of Salvia verbenaca Extract Contribute to Its Intestinal Antiinflammatory Effects in Experimental Colitis in Rats
by Teresa Vezza, Jose Alberto Molina-Tijeras, Alba Rodríguez-Nogales, Jose Garrido-Mesa, María de la Luz Cádiz-Gurrea, Antonio Segura-Carretero, María Reyes González-Tejero, María Elena Rodríguez-Cabezas, Julio Gálvez and Francesca Algieri
Antioxidants 2023, 12(12), 2071; https://doi.org/10.3390/antiox12122071 - 02 Dec 2023
Cited by 1 | Viewed by 1994
Abstract
Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammation with unpredictable symptom fluctuations. While there is no effective cure for IBD, various treatments aim to manage symptoms and improve the quality of life for affected individuals. In recent years, there has been growing [...] Read more.
Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammation with unpredictable symptom fluctuations. While there is no effective cure for IBD, various treatments aim to manage symptoms and improve the quality of life for affected individuals. In recent years, there has been growing interest in the potential benefits of certain natural plants and herbs in the management of IBD. In this regard, this study aimed to evaluate the immunomodulatory and anti-inflammatory effects of a well-characterized extract of Salvia verbenaca (S. verbenaca) in an experimental model of colitis in rats. Interestingly, the daily administration of S. verbenaca (10 and 25 mg/kg) effectively alleviated colitis symptoms, as evidenced by reduced weight/length ratio and colonic damage. Moreover, it reduced oxidative stress markers (MPO and GSH), decreased pro-inflammatory cytokine expression (Il-6, Il-12a, Il-1β, Il-23, Icam-1, Mcp-1, Cinc-1), and preserved the integrity of the intestinal barrier (Villin, Muc-2, Muc-3). These effects suggest S. verbenaca extract could represent a potential complementary candidate to treat gastrointestinal disorders. Its beneficial actions can be related to its antioxidant properties as well as the downregulation of the immune response, which can result in the improvement in the intestine epithelial barrier. Full article
(This article belongs to the Special Issue Significance of Antioxidant Mechanisms in Intestinal Inflammation)
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Review

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32 pages, 1584 KiB  
Review
Natural Products as Dietary Agents for the Prevention and Mitigation of Oxidative Damage and Inflammation in the Intestinal Barrier
by Carlos Martins-Gomes, Fernando M. Nunes and Amélia M. Silva
Antioxidants 2024, 13(1), 65; https://doi.org/10.3390/antiox13010065 - 01 Jan 2024
Cited by 1 | Viewed by 1916
Abstract
Food intake is a basic need to sustain life, but foodborne pathogens and food-related xenobiotics are also the main health concerns regarding intestinal barrier homeostasis. With a predominant role in the well-being of the entire human body, intestinal barrier homeostasis is strictly regulated [...] Read more.
Food intake is a basic need to sustain life, but foodborne pathogens and food-related xenobiotics are also the main health concerns regarding intestinal barrier homeostasis. With a predominant role in the well-being of the entire human body, intestinal barrier homeostasis is strictly regulated by epithelial and immune cells. These cells are also the main intervenients in oxidative stress and inflammation-related diseases in the intestinal tract, triggered, for example, by genetic/epigenetic factors, food additives, pesticides, drugs, pathogens, and their metabolites. Nevertheless, the human diet can also be seen as a solution for the problem, mainly via the inclusion of functional foods or nutraceuticals that may act as antioxidant/anti-inflammatory agents to prevent and mitigate acute and chronic oxidative damage and inflammation. A literature analysis of recent advances in this topic highlights the significant role of Nrf2 (nuclear factor erythroid 2-related factor 2) and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) pathways in these biological processes, with many natural products and phytochemicals targeting endogenous antioxidant systems and cytokine production and balance. In this review, we summarized and discussed studies using in vitro and in vivo models of the intestinal tract used to reproduce oxidative damage and inflammatory events, as well as the role of natural products as modulators of Nrf2 and NK-kB pathways. Full article
(This article belongs to the Special Issue Significance of Antioxidant Mechanisms in Intestinal Inflammation)
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22 pages, 1189 KiB  
Review
Melatonin Prevents Alcohol- and Metabolic Dysfunction- Associated Steatotic Liver Disease by Mitigating Gut Dysbiosis, Intestinal Barrier Dysfunction, and Endotoxemia
by Karli R. LeFort, Wiramon Rungratanawanich and Byoung-Joon Song
Antioxidants 2024, 13(1), 43; https://doi.org/10.3390/antiox13010043 - 25 Dec 2023
Cited by 1 | Viewed by 1926
Abstract
Melatonin (MT) has often been used to support good sleep quality, especially during the COVID-19 pandemic, as many have suffered from stress-related disrupted sleep patterns. It is less known that MT is an antioxidant, anti-inflammatory compound, and modulator of gut barrier dysfunction, which [...] Read more.
Melatonin (MT) has often been used to support good sleep quality, especially during the COVID-19 pandemic, as many have suffered from stress-related disrupted sleep patterns. It is less known that MT is an antioxidant, anti-inflammatory compound, and modulator of gut barrier dysfunction, which plays a significant role in many disease states. Furthermore, MT is produced at 400–500 times greater concentrations in intestinal enterochromaffin cells, supporting the role of MT in maintaining the functions of the intestines and gut–organ axes. Given this information, the focus of this article is to review the functions of MT and the molecular mechanisms by which it prevents alcohol-associated liver disease (ALD) and metabolic dysfunction-associated steatotic liver disease (MASLD), including its metabolism and interactions with mitochondria to exert its antioxidant and anti-inflammatory activities in the gut–liver axis. We detail various mechanisms by which MT acts as an antioxidant, anti-inflammatory compound, and modulator of intestinal barrier function to prevent the progression of ALD and MASLD via the gut–liver axis, with a focus on how these conditions are modeled in animal studies. Using the mechanisms of MT prevention and animal studies described, we suggest behavioral modifications and several exogenous sources of MT, including food and supplements. Further clinical research should be performed to develop the field of MT in preventing the progression of liver diseases via the gut–liver axis, so we mention a few considerations regarding MT supplementation in the context of clinical trials in order to advance this field of research. Full article
(This article belongs to the Special Issue Significance of Antioxidant Mechanisms in Intestinal Inflammation)
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