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Antioxidants
Special Issues
Antioxidant Capacity of Natural Products
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Antioxidant Capacity of Natural Products

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 2940

Special Issue Editor

Prof. Dr. Younghwa Kim

E-Mail Website
Guest Editor
School of Food Biotechnology and Nutrition, Kyungsung University, Busan 48434, Republic of Korea
Interests: food chemistry and experiment; food chemistry; food analysis; functional food science

Special Issue Information

Dear Colleagues,

This Special Issue aims to highlight studies relating to the antioxidant capacity of natural products. Excessive oxidative stress results from an imbalance between the production of oxidant derivatives and the defense mechanisms of antioxidants. This stress can result in the impairment of cells, proteins and DNA, contributing to the aging process. Moreover, oxidative stress is a critical factor in the pathogenesis and progression of diabetes, cancer and neurodegenerative disorders such as Alzheimer's disease.

Reactive oxygen species (ROS) are generally recognized as detrimental to health, capable of damaging cellular macromolecules and leading to processes such as apoptosis and necrosis. There are numerous substances from nature that can act as antioxidants. Among these, dietary phytochemicals, including phenolic compounds, vitamins and carotenoids, are potent antioxidants that can scavenge and intercept free radicals to prevent cellular damage. Researchers are actively investigating the properties and activities of promising antioxidants derived from natural sources as potential countermeasures against metabolic disorders.

Therefore, this Special Issue welcomes original research papers or review articles focusing on the antioxidant effects of diverse natural resources, as well as the mechanisms underlying their antioxidant actions both in vivo and in vitro.

We look forward to your contribution.

Sincerely,

Prof. Dr. Younghwa Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

14 pages, 1742 KiB  
Article
Comparison of the Antioxidant Potency of Four Triterpenes of Centella asiatica against Oxidative Stress
by Jinyeong Lim, Hana Lee, Seonghwa Hong, Junsoo Lee and Younghwa Kim
Antioxidants 2024, 13(4), 483; https://doi.org/10.3390/antiox13040483 - 18 Apr 2024
Viewed by 367
Abstract
We comparatively evaluated the antioxidant properties of key triterpenes from Centella asiatica, including asiatic acid (AA), asiaticoside, madecassic acid, and madecassoside, in several cell types, including skin fibroblasts, macrophages, hepatocytes, and endothelial cells, under conditions promoting oxidative stress. AA conferred the highest [...] Read more.
We comparatively evaluated the antioxidant properties of key triterpenes from Centella asiatica, including asiatic acid (AA), asiaticoside, madecassic acid, and madecassoside, in several cell types, including skin fibroblasts, macrophages, hepatocytes, and endothelial cells, under conditions promoting oxidative stress. AA conferred the highest viability on Hs68 cells exposed to ultraviolet B (UVB) irradiation. Triterpene pretreatment attenuated the UVB-induced generation of reactive oxygen species (ROS) and malondialdehyde (MDA), as well as the UVB-induced depletion of glutathione (GSH) in skin fibroblasts. AA most potently inhibited UVB-induced MMP generation, resulting in increased intracellular collagen levels. Pretreatment with triterpenes, particularly AA, significantly improved cell viability and attenuated TBHP-induced levels of ROS, alanine aminotransferase, and aspartate aminotransferase in HepG2 cells. Triterpenes attenuated ROS levels and reduced MDA and GSH expression in EA.hy926 cells. In RAW264.7 macrophages, production of nitric oxide, tumor necrosis factor-α, and interleukin-6 (indicators of LPS-induced oxidative damage) was significantly reduced by treatment with any of the triterpenes. Statistical analyses of triterpene biological activities using principal component analysis and hierarchical clustering revealed that AA exerted the greatest overall influence and showed remarkable activity in Hs68 and HepG2 cells. Full article
(This article belongs to the Special Issue Antioxidant Capacity of Natural Products)
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18 pages, 1906 KiB  
Article
Unveiling Glucosinolate Diversity in Brassica Germplasm and In Silico Analysis for Determining Optimal Antioxidant Potential
by Kanivalan Iwar, Kebede Taye Desta, Kingsley Ochar and Seong-Hoon Kim
Antioxidants 2024, 13(3), 376; https://doi.org/10.3390/antiox13030376 - 19 Mar 2024
Viewed by 714
Abstract
This study explored the glucosinolate (GSL) content in Brassica plants and utilized in silico analysis approach to assess their antioxidant capabilities. GSLs, present abundantly in Brassica vegetables, offer potential health advantages, including antioxidant effects. Employing Ultra-Performance Liquid Chromatography (UPLC) coupled with tandem mass [...] Read more.
This study explored the glucosinolate (GSL) content in Brassica plants and utilized in silico analysis approach to assess their antioxidant capabilities. GSLs, present abundantly in Brassica vegetables, offer potential health advantages, including antioxidant effects. Employing Ultra-Performance Liquid Chromatography (UPLC) coupled with tandem mass spectrometry (MS/MS), major GSLs were identified in 89 accessions from diverse species and subspecies. Statistical analysis and principal component analysis unveiled significant GSL variation and potential correlations among the Brassica germplasms. This study unveils the dominance of aliphatic GSLs over aromatic and indolyl compounds in all the accessions. Notably, Gluconapin (GNA) (33,049.23 µmol·kg−1 DW), Glucobrassicanapin (GBN) (9803.82 µmol·kg−1 DW), Progoitrin (PRO) (12,780.48 µmol·kg−1 DW) and Sinigrin (SIN) (14,872.93 µmol·kg−1 DW) were the most abundant compounds across the analyzed accessions. Moreover, in silico docking studies predicted promising antioxidant activity by evaluating the interactions of each GSL with antioxidant enzymes. Specifically, Sinigrin and Gluconapin exhibited a notably weaker influence on antioxidant enzymes. This provides key insights into the antioxidant potential of Brassica germplasm and highlights the importance of in silico analysis for evaluating bioactive properties. In general, the results of this study could be utilized in breeding programs to maximize GSL levels and antioxidant properties in Brassica crops and for developing functional foods with enhanced health benefits. Full article
(This article belongs to the Special Issue Antioxidant Capacity of Natural Products)
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20 pages, 3844 KiB  
Article
Insights on the Nutraceutical Properties of Different Specialty Teas Grown and Processed in a German Tea Garden
by Patricia Carloni, Federico Girolametti, Elisabetta Giorgini, Tiziana Bacchetti, Cristina Truzzi, Silvia Illuminati and Elisabetta Damiani
Antioxidants 2023, 12(11), 1943; https://doi.org/10.3390/antiox12111943 - 31 Oct 2023
Cited by 1 | Viewed by 1355
Abstract
European countries have recently started experimenting with growing and producing their own teas in small quantities, mainly for the specialty tea sector. To characterize European teas, this study investigated a set of five tea types obtained from different Camellia sinensis varieties/cultivars, representing various [...] Read more.
European countries have recently started experimenting with growing and producing their own teas in small quantities, mainly for the specialty tea sector. To characterize European teas, this study investigated a set of five tea types obtained from different Camellia sinensis varieties/cultivars, representing various oxidation grades (green, white, yellow, oolong, black), all grown and processed in the only tea garden in Europe (in Germany) that focuses on all five types. Hot and cold brews were studied by measuring the total phenolic (TPC) and flavonoid contents (TFC), the antioxidant capacity and UV-Vis spectra, also with the objective of discriminating between the different tea types and the different plant varieties. The dried leaves were analyzed to measure the content of essential and toxic elements and by ATR-FTIR spectroscopy to determine a chemical fingerprint for identifying the tea varieties and types. The average levels of TPC (hot brew = 5.82 ± 2.06; cold brew = 5.4 ± 2.46 mM GAEq), TFC (hot brew = 0.87 ± 0.309; cold brew = 0.87 ± 0.413 mM CAEq), and antioxidant capacity (ORAC assay-hot brew = 20.9 ± 605; cold brew = 21.8 ± 8.0 mM TXEq, ABTS assay-hot brew = 15.2 ± 5.09; cold brew = 15.1 ± 5.8 mM TXEq, FRAP assay-hot brew = 9.2 ± 3.84; cold brew = 10.4 ± 5.23 mM AAEq) observed compared well with those from other parts of the world such as China, Africa, and Taiwan. The hazard quotient <1 and the hazard index of 0.14 indicate that there is no non-carcinogenic risk from consumption of these teas. The obtained information is essential for elucidating the characteristics and the impact of tea processing and tea variety on the health benefits of these tea products coming from a single European tea garden. This multifaceted approach would help tea growers in Europe increase their knowledge on the health attributes of the teas they grow, ultimately leading to optimization of the nutraceutical properties of these teas. Full article
(This article belongs to the Special Issue Antioxidant Capacity of Natural Products)
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