Role of Natural Antioxidants in Cardiovascular Diseases and Cancers

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 1619

Special Issue Editor


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Guest Editor
Facultad de Ingenieria Química, Universidad Autónoma de Yucatán, Merida 97203, Mexico
Interests: bioactive compounds; functional foods; health

Special Issue Information

Dear Colleagues,

Cardiovascular disease (CVD) comprises health disorders associated with the heart and blood vessels, including diseases such as coronary heart disease, cerebrovascular disease, and rheumatic heart disease, among others. This group of diseases is the leading cause of death worldwide, accounting for an estimated of 17.9 million deaths each year, a third of which occur prematurely in people under the age of 70. Recently, cancers have been strongly associated with CVD, as people with CVD have a higher risk of developing cancer than those without CVD. Both groups of diseases share several risk factors, the most important of which are behavioral. Several studies have suggested that CVD and cancer can be prevented by lifestyle changes, including diet. In this context, studies suggest that a higher dietary antioxidant intake or antioxidant supplementation may reduce the incidence of these diseases. Antioxidants are essential components that help inhibit the oxidation process by scavenging free radicals in the human body, which result from the oxidation process and can severely damage an organism's cells. The World Health Organization has recognized the importance of antioxidants by advocating for an increase in their global consumption through dietary sources, as food intake is the primary way to obtain these compounds. Natural antioxidants are extensively present in functional foods. Beyond their fundamental nutritional capabilities, functional foods are those that have physiological advantages and/or lower the risk of chronic diseases. Among these plant-based natural antioxidants are polyphenols (phenolic acids, flavonoids, anthocyanins, lignans, and stilbenes), carotenoids (xanthophylls and carotenes), vitamins (E and C) and, more recently reported, peptides. Thus, increasing the knowledge about healthy affordable and available choices is essential for promoting the approval and sustained practice of healthy behaviors. We invite you to submit your latest research findings or a review article to this Special Issue, which will bring together current research that may serve as a useful collection of evidence for clinicians and medical professionals for the treatment of CVD and cancer through the consumption of functional foods rich in antioxidants, in addition to serving as a resource of updated information for researchers.

We look forward to your contribution.

Dr. Maira Rubi Segura Campos
Guest Editor

Manuscript Submission Information

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Keywords

  • natural antioxidants
  • oxidative stress
  • cardiovascular diseases
  • cancer

Published Papers (1 paper)

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Review

18 pages, 2905 KiB  
Review
Molecular Mechanism of Natural Food Antioxidants to Regulate ROS in Treating Cancer: A Review
by Muchtaridi Muchtaridi, Farhah Az-Zahra, Hendris Wongso, Luthfi Utami Setyawati, Dhania Novitasari and Emmy Hainida Khairul Ikram
Antioxidants 2024, 13(2), 207; https://doi.org/10.3390/antiox13020207 - 06 Feb 2024
Viewed by 1351
Abstract
Cancer is the second-highest mortality rate disease worldwide, and it has been estimated that cancer will increase by up to 20 million cases yearly by 2030. There are various options of treatment for cancer, including surgery, radiotherapy, and chemotherapy. All of these options [...] Read more.
Cancer is the second-highest mortality rate disease worldwide, and it has been estimated that cancer will increase by up to 20 million cases yearly by 2030. There are various options of treatment for cancer, including surgery, radiotherapy, and chemotherapy. All of these options have damaging adverse effects that can reduce the patient’s quality of life. Cancer itself arises from a series of mutations in normal cells that generate the ability to divide uncontrollably. This cell mutation can happen as a result of DNA damage induced by the high concentration of ROS in normal cells. High levels of reactive oxygen species (ROS) can cause oxidative stress, which can initiate cancer cell proliferation. On the other hand, the cytotoxic effect from elevated ROS levels can be utilized as anticancer therapy. Some bioactive compounds from natural foods such as fruit, vegetables, herbs, honey, and many more have been identified as a promising source of natural antioxidants that can prevent oxidative stress by regulating the level of ROS in the body. In this review, we have highlighted and discussed the benefits of various natural antioxidant compounds from natural foods that can regulate reactive oxygen species through various pathways. Full article
(This article belongs to the Special Issue Role of Natural Antioxidants in Cardiovascular Diseases and Cancers)
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