Special Issue "Oxidative Stress-Related Pharmacological Interventions Targeting CNS Disorders"

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 1 August 2024 | Viewed by 38

Special Issue Editors

Laboratory of Molecular Neuropharmacology, Division of Molecular Medicine, Ruđer Bošković Institute, POB 180 Zagreb, Croatia
Interests: pharmacology; neuroscience; natural products; antioxidant capacity; antimicrobial potential
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress (OS) plays a prominent role in the pathogenesis of many CNS disorders. This devastating condition results from an imbalance between the generation of reactive oxygen species (ROS) and their elimination by endogenous mechanisms of antioxidative defence systems, including various small non-enzymatic molecules and antioxidative enzymes. In comparison with other tissues, the brain is particularly vulnerable to ROS production and oxidative injury. Increased levels of ROS disturb the activity of redox-sensitive signalling pathways and induce oxidative damage and structural modifications of nucleic acids, proteins, and lipids, threatening neuronal functioning and ultimately progressing to neuronal death and behavioural and cognitive deficits. Together with accompanying neuroinflammation, uncontrolled immune response and increased release of proinflammatory mediators, enhanced ROS levels are one of the main mechanisms driving the onset and progression of various neurological disorders. OS is a hallmark of neurodegenerative disorders, epilepsy, multiple sclerosis, and psychiatric illnesses such as depression and schizophrenia. All these conditions require long-term standard therapy, often with disappointing results and unpleasant side-effects. Many natural compounds, either originating from dietary sources or dietary supplements, target various mechanisms underlying the impairment of brain functioning. Polyphenols in particular display powerful antioxidative, anti-inflammatory and neuroprotective effects and may regulate redox-dependent signalling pathways. These multilevel pharmacological possibilities and the better safety profile make them a promising strategy for alleviating symptoms of OS-initiated neuronal injury in CNS disorders.

We cordially invite authors to submit their latest research findings or comprehensive overviews bringing innovative perspectives regarding the pharmacological potential of antioxidants in alleviating the development, progression and symptom severity of OS-accompanied CNS disorders. We welcome studies that shed light on novel molecular and cellular mechanisms underlying the beneficial effects of antioxidants in various pathological conditions in vitro and in preclinical models but would like to encourage the submission of the results from human studies. Although cellular and animal models are both valuable and informative, novel advances in clinical trials are urgently needed to better understand the pharmacological potential of endogenous, dietary or synthetic antioxidants and synergistic interactions of their multimodal ways of action, predominantly related to endogenous mechanisms of antioxidative defence, regulation of redox-regulated signalling pathways and interplay with neuroinflammatory mechanisms, in the prevention and treatment of CNS disorders. 

Dr. Maja Jazvinšćak Jembrek
Dr. Josipa Vlainić
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • redox imbalance
  • oxidative stress
  • natural and synthetic antioxidants
  • endogenous antioxidative defence systems
  • neuroinflammation
  • cell signalling
  • clinical trials

Published Papers

This special issue is now open for submission.
Back to TopTop