Advances in Nanoantioxidants

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: closed (15 October 2021) | Viewed by 6861

Special Issue Editor


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Guest Editor
Department of Chemistry "Ugo Schiff", University of Florence, 50019 Sesto Fiorentino (FI), Italy
Interests: design and synthesis of bioinspired antioxidants; molecular, macromolecular and nano-supported antioxidants; redox chemistry

Special Issue Information

Dear Colleagues,

I am pleased to announce the Special Issue, entitled "Advances in Nanoantioxidants", that aims to present a collection of original papers and reviews examining new knowledge and developments in the field of nanoantioxidants.

The oxidative degradation of natural compounds or synthetic materials is associated to free radical oxidation process and the key function of antioxidants is to transform free radicals into harmless products terminating the adverse radical chain reactions. In recent years research on antioxidants moved toward nanotechnology, with the introduction of nanoantioxidants. This new category include inorganic nanoparticles possessing intrinsic antioxidant properties, antioxidant compounds or antioxidant enzymes covalently linked to nanoparticles, entrapped in nanogel or encapsulated into nanoparticles of different nature, size and shape.

Nanoantioxidants have shown potential applications in different sectors:

  • Nanomedicine as high-performance therapeutic oxidative stress regulators with potential applications in treating and preventing neurodegenerative conditions;
  • Material science as stabilizers capable of preventing the autoxidation of organic solvents, or able of protecting the packaged product and extending the shelf life of multilayered plastic material;
  • Environmental science for enhancing the growth of different variety of plants.

With this special issue, we aim to increase knowledge about nanoantioxidants, including the controversial aspects related to the use of nanoparticles. In particular, we are interested in synthesis and antioxidant activity of new nanomaterials, biological activity and toxicology of nanoantioxidants, studies of mechanisms of radical trapping by nanoantioxidants and new-found useful applications.

Articles and reviews dealing with the above subjects are welcome and will be considered for publication in this special issue.

Dr. Caterina Viglianisi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Free radicals
  • Antioxidants
  • Nano-structured antioxidants
  • Oxidative stress
  • Redox active compounds

Published Papers (1 paper)

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Research

16 pages, 6119 KiB  
Article
Nasal Spray Formulations Based on Combined Hyalurosomes and Glycerosomes Loading Zingiber officinalis Extract as Green and Natural Strategy for the Treatment of Rhinitis and Rhinosinusitis
by Eleonora Casula, Maria Letizia Manca, Matteo Perra, Jose Luis Pedraz, Tania Belen Lopez-Mendez, Antonio Lozano, Esteban Calvo, Marco Zaru and Maria Manconi
Antioxidants 2021, 10(7), 1109; https://doi.org/10.3390/antiox10071109 - 11 Jul 2021
Cited by 16 | Viewed by 5803
Abstract
A total green nanotechnological nasal spray has been manufactured and proposed as an alternative treatment of rhinitis and rhinosinusitis. It was obtained by combining the strengthening effect of liposomes on barrier function, the hydrating and lubricating properties of sodium hyaluronan and the anti-inflammatory [...] Read more.
A total green nanotechnological nasal spray has been manufactured and proposed as an alternative treatment of rhinitis and rhinosinusitis. It was obtained by combining the strengthening effect of liposomes on barrier function, the hydrating and lubricating properties of sodium hyaluronan and the anti-inflammatory and antioxidant activities of the extract of Zingiber officinalis. To this purpose, the extract was loaded in special phospholipid vesicles immobilized with hyaluronic acid (hyalurosomes), which were further enriched with glycerol in the water phase. Liposomes and glycerosomes were prepared as well and used as reference. Vesicles were oligolamellar and multicompartment, as confirmed by cryogenic transmission electron microscopy (cryo-TEM) observation, small in size (~140 nm) and negatively charged (~−23 mV). Spray characteristics were evaluated by using the Spraytec® and instant images, from which the plume angle was measured. The range of the droplet size distribution and the narrow spray angle obtained suggest a good nebulization and a possible local deposition in the nasal cavity. In vitro studies performed by using human keratinocytes confirmed the high biocompatibility of vesicles and their ability to effectively counteract oxidative damage on cells induced by hydrogen peroxide. The overall collected data suggest that our vesicles are suitable as nasal spray. Full article
(This article belongs to the Special Issue Advances in Nanoantioxidants)
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