Pleiotropic Effects Elicited by the Activation of the Nrf2 Pathway
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 10 November 2024
Special Issue Editor
Interests: evaluation of cytoprotective; neuroprotective effects of food; food components in animal models and humans; antioxidants; nutraceutical and therapeutic discoveries
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
The imbalance of oxidative homeostasis in cells/tissues (oxidative stress) plays a relevant role in the aetiology of numerous different diseases. The Keap1-Nrf2 complex and the antioxidant response element (ARE) pathway are involved in the recruitment of key factors in the defence of cellular redox homeostasis.
It is important to underline that, in addition to the activation of antioxidant mechanisms, the activation of the Nrf2 pathway is responsible for the modulation of other important cellular mechanisms, such as lipid metabolism, the inflammatory response, and proteostasis.
In this regard, most of the studies conducted so far, using both in in vivo and in vitro experimental models, have had the objective of evaluating the possible involvement of Nrf2 in the antioxidant/protective capacity of natural or synthetic molecules, while their effectiveness for other protective mechanisms associated with Nrf2 activation (e.g., cytoprotection, immunomodulation, proteostasis) has been little addressed. Furthermore, although the pleiotropic capacity of Nrf2 has long been recognized when the measurement of these biological activities is included in an experimental design, their connection with Nrf2 is not generally discussed (as it is considered separate from Nrf2).
In this Special Issue, we aim to examine the modulatory capacity of natural/synthetic molecules on different cellular mechanisms, such as oxidoreductive/protein homeostasis, lipid metabolism, and the inflammatory response, and to discuss their interconnection with the activation of the Nrf2 pathway. We encourage authors to present research results, both in vitro and in vivo, that support the pleiotropic ability of Nrf2 activation and may provide new insights into the links between the different cellular mechanisms involved.
Dr. Paolo Bergamo
Guest Editor
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Keywords
- Nrf2 pathway
- protein homeostasis
- oxidative/ER stress
- unfolded protein response
- immune modulation/ inflammation
- autophagy
- apoptosis
- animal models of human disease
- in vitro (2D, 3D) models of disease
