Special Issue "Efficacy of Dietary Molecules in the Modulation of Redox Homeostasis of Rodent Models"
Deadline for manuscript submissions: closed (15 June 2023) | Viewed by 7512
Interests: evaluation of cytoprotective/neuroprotective effects of food/food components in animal models; nutrients; antioxidants; reactive oxygen radical; nutraceutical and therapeutic discoveries
Oxidoreductive homeostasis (redox state) has a critical importance for aerobic animals, and its imbalance (oxidative distress) has been implicated in the aging process, as well as in a number of pathological conditions. In recent decades, experimental models have been used (in silico, in vitro, and in vivo) to evaluate the modulatory capacity of food molecules on the redox state. Although the understanding of biochemical mechanisms is an important topic, there are conflicting data on the mechanisms underlying their modulatory capacity both for the use of non-specific markers and for the influence of the experimental model used.
Rodents (mice, rats) are the most widely used animal models in biomedical research, although economic, ethical, biological, and methodological factors limit their utilization. By contrast, their complexity, the influence of metabolic processes on bioactive molecules’ bioavailability, and the use of allometric conversion for the used doses greatly contribute to the translation of research results from animals to humans.
This Special Issue aims to collect documents dealing with the modulatory capacity of foods/food extracts/bioactive molecules on the redox state of healthy/diseased rodents through the use of responsible/specific biomarkers. Studies investigating the underlying molecular mechanisms and the contribution of different cellular pathways will be particularly appreciated.
Dr. Paolo Bergamo
Manuscript Submission Information
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- Dietary compounds
- Rodent models
- Antioxidant defenses
- Oxidative stress
- Redox signaling
- Cellular mechanisms underlying food/biomolecule-induced redox signaling