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Journals
Antioxidants
Special Issues
Natural Antioxidants in Animal Immunity—2nd Edition
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Natural Antioxidants in Animal Immunity—2nd Edition

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: closed (15 January 2024) | Viewed by 3903

Special Issue Editors

Prof. Dr. Xiang Zhong

E-Mail Website
Guest Editor
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
Interests: epitranscriptome; m6A RNA methylation; mucosal immunity; stem cells; gut–liver axis; nutrition metabolism; plant extracts
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Xin Wu

E-Mail Website
Guest Editor
Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China
Interests: nutrition metabolism and immunity; including amino acids; nucleotide and microelements with the physiological functions for the well-being of animals and people
Special Issues, Collections and Topics in MDPI journals
Dr. Vanessa Leone

E-Mail Website
Guest Editor
Department of Animal & Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA
Interests: animal biologics and metabolism; host–microbe interactions
Special Issues, Collections and Topics in MDPI journals
Dr. Lili Zhang

E-Mail Website
Guest Editor
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
Interests: nutrition metabolism; plant extracts; probiotics; intestinal barrier function; gut–liver axis; antioxidant
Special Issues, Collections and Topics in MDPI journals
Dr. Dan Wan

E-Mail Website
Guest Editor
Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China
Interests: innate immunity; gut microbial; microelement homeostasis; ferroptosis
Special Issues, Collections and Topics in MDPI journals
Dr. Li Dong

E-Mail Website
Guest Editor
College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Interests: intestine; inflammation; antioxidants; intestinal epithelial cells; intestinal stem cells; feed additives; nutritional regulation
Dr. Shuangshuang Guo

E-Mail Website
Guest Editor
School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China
Interests: poultry nutrition; gut health; probiotics; plant extracts; mucosal immunity

Special Issue Information

Dear Colleagues,

Our previous Special Issue on “Natural Antioxidants in Animal Immunity” (https://www.mdpi.com/journal/antioxidants/special_issues/Antioxidants_Animal_Immunity), published in the 2022 volume of Antioxidants, received an overwhelming number of submissions and was a successful compilation of research and review articles. As this is a rapidly evolving topic, we would like to further explore the role of natural antioxidants in animal immunity with a follow-up Special Issue for the year 2023. 

Antioxidant defence systems are essential for maintaining optimum health in animals. In the current intensive animal production systems, the environment, unbalanced nutrition, the administration of drugs, and physical and physiological stress cause an adverse effect on the immune function of different animal species, with the emergence and re-emergence of diseases. These phenomena affect animal health and decrease the animal production efficiency, thereby increasing production costs. A better understanding of immune system development and the factors that affect the immune system can lead to the production of more resilient animals with increased immune competence. Novel multidisciplinary collaborative research programs that integrate animal nutrition, mucosal immunology, cell metabolism, and molecular biology are urgently needed. Antioxidants such as polyphenols, antioxidant vitamins (C, E, A), and minerals (iron, zinc, selenium) generally enhance cellular and noncellular immunity by maintaining the functional and structural integrity of immune cells. Antioxidants may provide the strategic future of the industry, ensuring health in humans and animals.

This Special Issue particularly focuses on:

  • The molecular networks of immune system development in young animals.
  • Crosstalk between microbes (virus and microbiota) and mucosal immunity in animals.
  • The roles of RNA methylation in animal immunity.
  • The impact of oxidative stress on the immune function of animals.
  • The roles of antioxidants in animal immunity.

All scientific works (original research papers and long reviews) in this field are highly welcome.

Prof. Dr. Xiang Zhong
Prof. Dr. Xin Wu
Dr. Vanessa Leone
Dr. Lili Zhang
Dr. Dan Wan
Dr. Li Dong
Dr. Shuangshuang Guo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • animal
  • immunity
  • microbiota
  • virus
  • oxidative stress
  • iron or other microelement
  • plant extracts

Published Papers (2 papers)

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Research

19 pages, 5077 KiB  
Article
A Mixture of Formic Acid, Benzoic Acid, and Essential Oils Enhanced Growth Performance via Modulating Nutrient Uptake, Mitochondrion Metabolism, and Immunomodulation in Weaned Piglets
by Xinyu Wang, Tanyi Deng, Xuemei Zhou, Licui Chu, Xiangfang Zeng, Shihai Zhang, Wutai Guan and Fang Chen
Antioxidants 2024, 13(2), 246; https://doi.org/10.3390/antiox13020246 - 19 Feb 2024
Viewed by 1134
Abstract
This study aimed to evaluate the effects of a complex comprising formic acid, benzoic acid, and essential oils (AO3) on the growth performance of weaned piglets and explore the underlying mechanism. Dietary AO3 supplementation significantly enhanced the average daily gain (ADG) and average [...] Read more.
This study aimed to evaluate the effects of a complex comprising formic acid, benzoic acid, and essential oils (AO3) on the growth performance of weaned piglets and explore the underlying mechanism. Dietary AO3 supplementation significantly enhanced the average daily gain (ADG) and average daily feed intake (ADFI), while decreasing the feed conversion rate (FCR) and diarrhea rate (p < 0.05). Additionally, AO3 addition altered the fecal microflora composition with increased abundance of f_Prevotellaceae. LPS challenges were further conducted to investigate the detailed mechanism underlying the benefits of AO3 supplementation. The piglets fed with AO3 exhibited a significant increase in villus height and decrease in crypt depth within the jejunum, along with upregulation of ZO-1, occludin, and claudin-1 (p < 0.05) compared with those piglets subjected to LPS. Furthermore, AO3 supplementation significantly ameliorated redox disturbances (T-AOC, SOD, and GSH) and inflammation (TNF-α, IL-1β, IL-6, and IL-12) in both the serum and jejunum of piglets induced by LPS, accompanied by suppressed activation of the MAPK signaling pathway (ERK, JNK, P38) and NF-κB. The LPS challenge downregulated the activation of the AMPK signaling pathway, mRNA levels of electron transport chain complexes, and key enzymes involved in ATP synthesis, which were significantly restored by the AO3 supplementation. Additionally, AO3 supplementation restored the reduced transport of amino acids, glucose, and fatty acids induced by LPS back to the levels observed in the control group. In conclusion, dietary AO3 supplementation positively affected growth performance and gut microbiota composition, also enhancing intestinal barrier integrity, nutrient uptake, and energy metabolism, as well as alleviating oxidative stress and inflammation under LPS stimulation. Full article
(This article belongs to the Special Issue Natural Antioxidants in Animal Immunity—2nd Edition)
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19 pages, 5469 KiB  
Article
Effects of Tannic Acid Supplementation on the Intestinal Health, Immunity, and Antioxidant Function of Broilers Challenged with Necrotic Enteritis
by Huiping Xu, Xiaodan Zhang, Peng Li, Yimeng Luo, Jianyang Fu, Lu Gong, Zengpeng Lv and Yuming Guo
Antioxidants 2023, 12(7), 1476; https://doi.org/10.3390/antiox12071476 - 24 Jul 2023
Cited by 4 | Viewed by 1799
Abstract
Clostridium perfringens causes necrotic enteritis (NE) after proliferation in the intestine of poultry, resulting in considerable losses to the poultry industry. This study aimed to investigate the impact of tannic acid on the antioxidant, immunity, and gut health of broilers with NE. In [...] Read more.
Clostridium perfringens causes necrotic enteritis (NE) after proliferation in the intestine of poultry, resulting in considerable losses to the poultry industry. This study aimed to investigate the impact of tannic acid on the antioxidant, immunity, and gut health of broilers with NE. In the experiment, 630 one-day-old Cobb500 male chicks were randomly divided into six treatment groups, with seven replicate cages and with fifteen birds in each cage. The treatment groups were as follows: control group (NC), challenged group (PC), and challenged NE chickens treated with 250, 500, 750, and 1000 mg/kg tannic acid (PTA1, PTA2, PTA3, and PTA4, respectively). To induce NE, coccidia vaccine and Clostridium perfringens were administered on day 19 and days 22–28, respectively. Indexes related to antioxidant, immune, and intestinal health were measured on days 28 and 35. During the infection period, we observed significant increases in fecal water content, D-LA, TNF-α, and malondialdehyde concentrations (p < 0.05). Conversely, significant decreases were noted in chyme pH and in T-AOC, IL-4, and IL-10 concentrations (p < 0.05). The addition of tannic acid exhibited a linear decrease in fecal water content and TNF-α concentration (p < 0.05). Furthermore, tannic acid supplementation resulted in a quadratic curve decrease in D-LA concentration and linear increases in T-AOC, IL-4, and IL-10 (p < 0.05). Cecal microbiological analysis revealed that Ruminococcaceae and Butyricimona were dominant in PTA3. In conclusion, the dietary addition of tannic acid may reduce the negative effects of NE by increasing antioxidant and anti-inflammatory capacity, improving the intestinal barrier, and regulating the intestinal flora. Full article
(This article belongs to the Special Issue Natural Antioxidants in Animal Immunity—2nd Edition)
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