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Antioxidants
Special Issues
Plant Phenolics: Extraction, Analysis and Their Antioxidant Properties
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Plant Phenolics: Extraction, Analysis and Their Antioxidant Properties

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 20 July 2024 | Viewed by 1567

Special Issue Editors

Prof. Dr. Vicente Micol

E-Mail Website
Guest Editor
Instituto de Investigación, Desarrollo e Innovación en Biotecnologia Sanitaria at Miguel Hernández University, Elche, Spain
Interests: natural compounds; polyphenols; metabolic disorders; obesity; cancer; antimicrobial; skin; cosmetics
Special Issues, Collections and Topics in MDPI journals
Dr. Francisco Javier Álvarez-Martínez

E-Mail Website
Guest Editor
Institute of Research, Development and Innovation in Healthcare Biotechnology of Elche (IDiBE), Miguel Hernández University (UMH), Alicante, Spain
Interests: antimicrobial; antimicrobial resistance; natural compounds; oxidative stress; polyphenols; skin health

Special Issue Information

Dear Colleagues,

Plant polyphenols are secondary metabolites bearing important biological activities. Plant species, origin and even season influence the qualitative and quantitative polyphenolic composition of plant extracts, but these factors are not the only ones influencing the quality of the final polyphenolic product. Extraction, purification drying and downstream processes impact the final composition of the products and deserve to be studied and correlated within analytical and biological activity parameters.

This Special Issue aims to collect original papers focused on the influence of the extractive procedures (including pre- and processing strategies) on the biological activity of plant polyphenolic products, with an especial interest in their antioxidant properties. Reviews covering the actual state of the art of the main extractive techniques are also welcome. The influence of these techniques should always be accompanied by analytical and/or biological activity data that allow the real impact of the study to be understood. The inclusion of mass balances, yields and any other quantitative data is also encouraged. Furthermore, in pursuit of a sustainable world, industrial processes are forced to follow a new model of responsible production and consumption that minimizes waste generation and maintains, as long as possible, the value of products, materials and resources in the economy, avoiding greater pressure on the environment. All these aspects would also be considered.

Prof. Dr. Vicente Micol
Dr. Francisco Javier Álvarez-Martínez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant polyphenols
  • extraction
  • drying
  • biological activity
  • sustainable processes
  • circular economy
  • antioxidant properties 
  • flavonoids
  • tannins
  • phenolic acids
  • anthocyanins
  • coumarins
  • lignans
  • quinones
  • stilbens
  • curcuminoids

Published Papers (1 paper)

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Research

21 pages, 8025 KiB  
Article
Chemical Characterization of Honeysuckle Polyphenols and Their Alleviating Function on Ultraviolet B-Damaged HaCaT Cells by Modulating the Nrf2/NF-κB Signaling Pathways
by Shuo-Lei Zheng, Yu-Mei Wang, Chang-Feng Chi and Bin Wang
Antioxidants 2024, 13(3), 294; https://doi.org/10.3390/antiox13030294 - 28 Feb 2024
Viewed by 926
Abstract
Scientific evidence attests that the epidermis receives excessive ultraviolet B (UVB) radiation, triggering the generation of substantial quantities of reactive oxygen species (ROS), which disrupted the delicate equilibrium of oxidation–reduction, leading to oxidative stress and inflammation. The historical use of honeysuckle polyphenols (HPs) [...] Read more.
Scientific evidence attests that the epidermis receives excessive ultraviolet B (UVB) radiation, triggering the generation of substantial quantities of reactive oxygen species (ROS), which disrupted the delicate equilibrium of oxidation–reduction, leading to oxidative stress and inflammation. The historical use of honeysuckle polyphenols (HPs) has garnered our attention due to their efficacy in inhibiting oxidative damage. In this study, HPs were prepared from honeysuckle flowers employing an ultrasonic-assisted extraction method and quantitatively analyzed by a LC–MS/MS, and the mechanisms underlying HPs’ antioxidative and anti-inflammatory effects on a UVB-irradiated HaCaT cell model were systematically investigated. The results showed that HPs had a significant cellular repair effect on UVB-irradiated HaCaT cells (p < 0.001). The mechanism of action indicated that HPs could allow Nrf2 to enter the nucleus by regulating the dissociation of Nrf2 from Keap1, which further increases the activity of downstream proteases (SOD and CAT), increases ROS scavenging, and reduces the intracellular malondialdehyde (MDA) level. In addition, HPs could down-regulate Toll-like receptor 4 (TLR4) and inhibit NF-κB (P65) dissociating from IκBα, resulting in a decrease in NF-κB (P65) entry into the nucleus and a decrease in inflammatory factors (TNF-α, IL-6, and IL-1β). In addition, four key compounds in HPs, including chlorogenic acid, quercetin, isorhamnetin, and luteolin, were selected to verify the mechanism of HPs repairing UVB damage using molecular docking techniques. The experiment suggested that four key active compounds could effectively occupy the Kelch homologue (Kelch) structural domain of Keap1, competitively bind with Nrf2, and facilitate the promotion of Nrf2 binding, ultimately enhancing the translocation of Nrf2 into the nucleus. In addition, four key active compounds could effectively interact with NF-κB (P65) through hydrogen bonding, van der Waals forces, and electrostatic forces to inhibit its entry into the nucleus. In summary, HPs can effectively repair the damage of HaCaT cells by UVB radiation and can be used to develop health and cosmetic products for the treatment of UV radiation-induced diseases. Full article
(This article belongs to the Special Issue Plant Phenolics: Extraction, Analysis and Their Antioxidant Properties)
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