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Antioxidants
Special Issues
Novel Antioxidant Mechanisms for Health and Diseases
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Novel Antioxidant Mechanisms for Health and Diseases

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1559

Special Issue Editor

Dr. Yoshihisa Koyama

E-Mail Website
Guest Editor
Department of Neuroscience and Cell Biology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita 565-0871, Osaka, Japan
Interests: antioxidant therapy; hydrogen

Special Issue Information

Dear Colleagues,

Antioxidant therapy effectively addresses oxidative-stress-related diseases. These conditions arise from the depletion of endogenous antioxidants, which leads to oxidative stress. Therefore, supplementation with exogenous antioxidants, including vitamins and polyphenols, has been suggested. However, some studies report potential drawbacks, such as neutralizing beneficial reactive oxygen species (ROS) or requiring excessive doses for effectiveness, making clinical application challenging. Oxidative stress plays a role in various contexts, from pathological conditions to fatigue and the side effects of anticancer drugs. Therefore, rapid and precise replenishment of antioxidants that specifically counteract harmful ROS is crucial.

Emerging approaches to antioxidant treatment offer new perspectives. Nutrigenomics-based treatments aim to enhance the body's antioxidant capacity by influencing gene expression through dietary choices. Nano-antioxidant therapy employs inorganic substances to continuously generate antioxidants within the body. There are also treatments that increase the production of antioxidants by regulating the microbiome. These treatments are innovative antioxidant therapies that differ from those used in the past, aiming to enhance the body's antioxidant capacity by modifying the internal environment. The objective of this Special Issue is to delve into these novel antioxidant treatments to gain a better understanding of the new mechanisms that regulate antioxidant activity in the body. We hope that this Special Issue will lead to the discovery of new antioxidant treatments for oxidative-stress-related diseases.

Dr. Yoshihisa Koyama
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant therapy
  • reactive oxygen species
  • oxidative stress
  • nano-antioxidant therapy
  • nutrigenomics
  • microbiome

Published Papers (2 papers)

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Research

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14 pages, 1647 KiB  
Article
TNFRSF1B Signaling Blockade Protects Airway Epithelial Cells from Oxidative Stress
by Javier Checa, Pau Fiol, Marta Guevara and Josep M. Aran
Antioxidants 2024, 13(3), 368; https://doi.org/10.3390/antiox13030368 - 18 Mar 2024
Viewed by 779
Abstract
Progressive respiratory airway destruction due to unresolved inflammation induced by periodic infectious exacerbation episodes is a hallmark of cystic fibrosis (CF) lung pathology. To clear bacteria, neutrophils release high amounts of reactive oxygen species (ROS), which inflict collateral damage to the neighboring epithelial [...] Read more.
Progressive respiratory airway destruction due to unresolved inflammation induced by periodic infectious exacerbation episodes is a hallmark of cystic fibrosis (CF) lung pathology. To clear bacteria, neutrophils release high amounts of reactive oxygen species (ROS), which inflict collateral damage to the neighboring epithelial cells causing oxidative stress. A former genome-wide small interfering RNA (siRNA) screening in CF submucosal gland cells, instrumental for mucociliary clearance, proposed tumor necrosis factor receptor superfamily member 1B (TNFRSF1B; TNFR2) as a potential hit involved in oxidative stress susceptibility. Here, we demonstrate the relevance of TNFRSF1B transcript knock-down for epithelial cell protection under strong oxidative stress conditions. Moreover, a blockade of TNFR signaling through its ligand lymphotoxin-α (LTA), overexpressed in airway epithelial cells under oxidative stress conditions, using the anti-tumor necrosis factor (TNF) biologic etanercept significantly increased the viability of these cells from a toxic oxidizing agent. Furthermore, bioinformatic analyses considering our previous RNA interference (RNAi) screening output highlight the relevance of TNFRSF1B and of other genes within the TNF pathway leading to epithelial cell death. Thus, the inhibition of the LTα3-TNFR2 axis could represent a useful therapeutic strategy to protect the respiratory airway epithelial lining from the oxidative stress challenge because of recurrent infection/inflammation cycles faced by CF patients. Full article
(This article belongs to the Special Issue Novel Antioxidant Mechanisms for Health and Diseases)
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Review

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15 pages, 838 KiB  
Review
The Impact of Curcumin, Resveratrol, and Cinnamon on Modulating Oxidative Stress and Antioxidant Activity in Type 2 Diabetes: Moving beyond an Anti-Hyperglycaemic Evaluation
by Michalina Banaszak, Ilona Górna, Dagmara Woźniak, Juliusz Przysławski and Sławomira Drzymała-Czyż
Antioxidants 2024, 13(5), 510; https://doi.org/10.3390/antiox13050510 - 24 Apr 2024
Viewed by 444
Abstract
Research indicates that up to half of the population resorts to dietary supplements for managing diseases such as type 2 diabetes rather than changing their nutritional habits. These supplements not only aim to have an anti-hyperglycaemic effect but also seek to reduce oxidative [...] Read more.
Research indicates that up to half of the population resorts to dietary supplements for managing diseases such as type 2 diabetes rather than changing their nutritional habits. These supplements not only aim to have an anti-hyperglycaemic effect but also seek to reduce oxidative stress to prevent diabetes complications. This systematic literature systematic review aims to evaluate the efficacy of curcumin, resveratrol, and cinnamon in modulating oxidative stress and antioxidant activity in individuals with type 2 diabetes. Data were collected from PubMed, Web of Sciences, and Scopus databases regarding the impact of curcumin, resveratrol, and cinnamon on total antioxidant capacity (TAC), malondialdehyde (MDA), tumour necrosis factor α (TNF-α), interleukin 6 (IL-6), and high-sensitivity C-reactive protein (hs-CRP) levels for this review. Effect sizes for each study were calculated using Cohen’s or Hedges’s d coefficient. Parameters of oxidative stress and inflammatory status, such as TAC, MDA, TNF-α, IL-6, and hs-CRP, improved following phytochemicals. Additionally, curcumin, resveratrol, and cinnamon exhibited regulatory effects on carbohydrate metabolism by reducing glucose, insulin, and glycated haemoglobin concentrations and lipid metabolism by lowering total cholesterol (TC), low-density lipoprotein (LDL), and triglycerides (TG) and increasing high-density lipoprotein (HDL). Incorporating curcumin, resveratrol, and cinnamon into diets may be beneficial for maintaining organism homeostasis and improving metabolic control in individuals with type 2 diabetes. However, the conflicting results reported in the literature highlight the need for further detailed investigations into the effectiveness of phytochemical use for type 2 diabetes. Full article
(This article belongs to the Special Issue Novel Antioxidant Mechanisms for Health and Diseases)
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