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Journals
Antioxidants
Special Issues
Oxidative Stress and Biomarkers in Metabolic Disorders
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Oxidative Stress and Biomarkers in Metabolic Disorders

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 1322

Special Issue Editors

Dr. Patrice Maboudou

E-Mail Website
Guest Editor
Centre de Bio-Pathologie, CHRU Lille, 59000 Lille, France
Interests: human metabolism; metabolic disease; biomarkers; biochemistry; cell biology
Dr. Guillaume Grzych

E-Mail Website
Guest Editor
CHU Lille, Centre de Biologie Pathologie Génétique, Service Hormonologie Métabolisme Nutrition Oncologie, F-59000 Lille, France
Interests: biochemistry; nitrous oxide; biomarkers; human metabolism; human genetics; genomics

Special Issue Information

Dear Colleagues,

Oxidative stress is an imbalance between the production of free radicals and the capacity of the antioxidant defense system to neutralize these reactive oxygen species. It is associated with various chronic diseases such as cardiovascular diseases, diabetes, cancer, and aging. Oxidative stress causes cellular damage by oxidizing macromolecules, including lipids, proteins, and DNA. This damage can disrupt metabolic pathways and lead to cellular dysfunction. Conversely, dysregulations of cellular intermediary metabolism can also lead to dysregulations of oxidative stress, such as a decrease in antioxidant molecules like glutathione.

We invite you to submit your studies and reviews related to dysregulations of human metabolism in the context of oxidative stress, whether as causes or consequences of oxidative dysregulation and associated pathologies. Articles may focus on biochemical or metabolomic approaches to evaluate oxidative stress.

Dr. Patrice Maboudou
Dr. Guillaume Grzych
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • metabolic disorders
  • human metabolism
  • biomarkers
  • cardiovascular diseases
  • cancer
  • metabolomics
  • chronic diseases

Published Papers (1 paper)

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Research

21 pages, 1809 KiB  
Article
Advanced Oxidation Protein Products Are Strongly Associated with the Serum Levels and Lipid Contents of Lipoprotein Subclasses in Healthy Volunteers and Patients with Metabolic Syndrome
by Iva Klobučar, Lidija Hofmann, Hansjörg Habisch, Margarete Lechleitner, Lucija Klobučar, Matias Trbušić, Gudrun Pregartner, Andrea Berghold, Tobias Madl, Saša Frank and Vesna Degoricija
Antioxidants 2024, 13(3), 339; https://doi.org/10.3390/antiox13030339 - 11 Mar 2024
Viewed by 965
Abstract
The association between advanced oxidation protein products (AOPPs) and lipoprotein subclasses remains unexplored. Therefore, we performed comprehensive lipoprotein profiling of serum using NMR spectroscopy and examined the associations of lipoprotein subclasses with the serum levels of AOPPs in healthy volunteers (HVs) and patients [...] Read more.
The association between advanced oxidation protein products (AOPPs) and lipoprotein subclasses remains unexplored. Therefore, we performed comprehensive lipoprotein profiling of serum using NMR spectroscopy and examined the associations of lipoprotein subclasses with the serum levels of AOPPs in healthy volunteers (HVs) and patients with metabolic syndrome (MS). The serum levels of AOPPs were significantly positively correlated with the serum levels of very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and low-density lipoprotein (LDL); however, they were significantly negatively correlated with high-density lipoprotein (HDL). These lipoproteins (and their subclasses) differed markedly regarding the direction of correlations between their lipid contents and AOPPs. The strength of the correlations and the relative contributions of the subclasses to the correlations were different in the HVs and patients with MS. As revealed by orthogonal partial least squares discriminant analyses, the serum levels of IDL were strong determinants of AOPPs in the HVs, whereas the serum levels of VLDL and the lipid content of LDL were strong determinants in both groups. We conclude that IDL, VLDL, and LDL facilitate, whereas HDL diminishes the bioavailability of serum AOPPs. The presence of MS and the lipid contents of the subclasses affect the relationship between lipoproteins and AOPPs. Full article
(This article belongs to the Special Issue Oxidative Stress and Biomarkers in Metabolic Disorders)
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