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Antibiotics
Special Issues
Essential Oil and Plant Extracts: Chemical Composition and Antimicrobial Activity
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Essential Oil and Plant Extracts: Chemical Composition and Antimicrobial Activity

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Plant-Derived Antibiotics".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 5023

Special Issue Editors

Dr. Bojana Danilović

E-Mail Website
Guest Editor
Faculty of Technology, University of Niš, Bulevar Oslobođenja 124, 16000 Leskovac, Serbia
Interests: antimicrobial activity; essential oils; food preservation; antimicrobial coatings
Dr. Ivana Karabegović

E-Mail Website
Guest Editor
Faculty of Technology, University of Niš, Bulevar Oslobođenja 124, 16000 Leskovac, Serbia
Interests: food preservation; extraction techniques; optimization and mathematical modeling
Dr. Jelena Stanojević

E-Mail Website
Guest Editor
Faculty of Technology, University of Niš, Bulevar Oslobođenja 124, 16000 Leskovac, Serbia
Interests: mass spectrometry; chemical composition of essential oils and plant extracts; antioxidant activity; photochemistry

Special Issue Information

Dear Colleagues,

Essential oils and plant extracts are volatile and aromatic mixtures of various compounds with pronounced biological activity. Their chemical composition depends on the source from which they are derived and the type of their isolation, which affects the antimicrobial activity of the oil. Many studies have focused on the connection between the chemical composition of plant derivatives, such as essential oils and extracts, and their antimicrobial activity. Currently, researchers are focusing on the biological activity of these plant derivatives and their application in various matrices as food, pharmaceutical and cosmetic preparations. Therefore, the main subject of this Special Issue is the determination of the chemical composition of essential oils and plant extracts, and the examination of their antimicrobial activity. Manuscripts including the practical application of essential oils and plant extracts based on their antimicrobial activity in food protection, food packaging materials and other aspects related to the food industry are especially encouraged.

Dr. Bojana Danilović
Dr. Ivana Karabegović
Dr. Jelena Stanojević
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • essential oils
  • plant extracts
  • composition
  • antimicrobial activity
  • food protection
  • antimicrobial packaging

Published Papers (3 papers)

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Research

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13 pages, 1117 KiB  
Article
Polyphenolic Composition and Antimicrobial, Antioxidant, Anti-Inflammatory, and Antihyperglycemic Activity of Different Extracts of Teucrium montanum from Ozren Mountain
by Pero Sailović, Božana Odžaković, Darko Bodroža, Jelena Vulić, Jasna Čanadanović-Brunet, Jelena Zvezdanović and Bojana Danilović
Antibiotics 2024, 13(4), 358; https://doi.org/10.3390/antibiotics13040358 - 14 Apr 2024
Viewed by 1244
Abstract
Teucrium montanum has widespread use in folk medicine on the Balkan peninsula. In order to scientifically justify this use, the composition and biological activity of aqueous, ethanol, and acetone extract were investigated in this study. Moreover, acetone and ethanol extracts were obtained from [...] Read more.
Teucrium montanum has widespread use in folk medicine on the Balkan peninsula. In order to scientifically justify this use, the composition and biological activity of aqueous, ethanol, and acetone extract were investigated in this study. Moreover, acetone and ethanol extracts were obtained from the plant material previously exhausted by water extraction. A total of 27 compounds were detected in extracts by UHPLC-DAD-MS/MS analysis, with all of them present in acetone and ethanol extracts. Consequentially, the acetone and ethanol extracts showed higher contents of total phenols of 23% and 18%, respectively, compared to the water extract. The results indicated high biological potential in the investigated extracts. Among all extracts, the aqueous extract showed slightly higher antimicrobial potential, especially against Gram-positive strains, probably due to the release of components soluble in water from the dry unexhausted plant material. On the other hand, the acetone and ethanol extracts had significantly higher antioxidative (by 20%), anti-inflammatory activity (up to 3 and 4 times higher, respectively), and α-glucosidase inhibitory potential (3 times higher) than the aqueous extract. The results of this investigation reveal the great potential of the use of T. montanum in various branches of food, cosmetics, and the pharmaceutical industry. An important part of this research is a confirmation that, once exhausted by water extraction, for example by hydrodistillation, T. montanum plant material can be reused for obtaining valuable products with a wide range of biological activities. Full article
(This article belongs to the Special Issue Essential Oil and Plant Extracts: Chemical Composition and Antimicrobial Activity)
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15 pages, 828 KiB  
Article
Development and Validation of a Gas Chromatography–Mass Spectrometry Method for the Analysis of the Novel Plant-Based Substance with Antimicrobial Activity
by Viktor A. Filatov, Egor A. Ilin, Olesya Yu. Kulyak and Elena I. Kalenikova
Antibiotics 2023, 12(10), 1558; https://doi.org/10.3390/antibiotics12101558 - 22 Oct 2023
Viewed by 1592
Abstract
The research into new pharmaceutical substances based on essential oils, individual biologically active phytochemicals, and plant extracts is a priority in field of pharmaceutical sciences. A novel multicomponent substance based on Melaleuca alternifolia (M. alternifolia) leaf oil (TTO), 1,8-cineole (eucalyptol), and [...] Read more.
The research into new pharmaceutical substances based on essential oils, individual biologically active phytochemicals, and plant extracts is a priority in field of pharmaceutical sciences. A novel multicomponent substance based on Melaleuca alternifolia (M. alternifolia) leaf oil (TTO), 1,8-cineole (eucalyptol), and (-)-α-bisabolol with potent synergetic antimicrobial activity was investigated and suggested for the treatment of seborrheic dermatitis (SD) and dandruff. The objective of this research was to establish and validate a specific, accurate, and precise gas chromatography–mass spectrometry (GC–MS) method for further quantitative and qualitative analysis in order to ensure quality control. The main parameters of validation were suitability, specificity, linearity, accuracy, and intermediate precision according to the European Pharmacopoeia (XI edition), Russian Pharmacopoeia (XIV edition), and some parameters of ICH requirements. The peaks of fifteen chemical phytoconstituents were identified in the test sample solution with the prevalence of (−)-α-bisabolol (27.67%), 1,8-cineole (25.63%), and terpinen-4-ol (16.98%). These phytochemicals in the novel substance were chosen for standardization and validation of the GC–MS method. The chosen chromatographic conditions were confirmed for testing of the plant-based substance in a suitability test. It was established that the GC–MS method provides a significant separation, symmetry of peaks and resolution between phytochemicals. The calibration curves of each phytochemical had good linearity (R2 > 0.999) in five concentrations. In the same concertation range, the accuracy of terpinen-4-ol, 1,8-cineol, and (−)-α-bisabolol determination using the method of additives was 98.3–101.60%; the relative standard deviation (RSD) ranged from 0.89% to 1.51% and corresponded to requirements. The intraday and interday precision was ≤2.56%. Thus, the GC–MS method was validated to be specific, sensitive, linear, accurate, and precise. This GC–MS method could be recommended as a routine analytic technique for multicomponent plant-based substances-enriched terpenes. Full article
(This article belongs to the Special Issue Essential Oil and Plant Extracts: Chemical Composition and Antimicrobial Activity)
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Review

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28 pages, 973 KiB  
Review
Use of Essential Oils to Counteract the Phenomena of Antimicrobial Resistance in Livestock Species
by Carmine Lupia, Fabio Castagna, Roberto Bava, Maria Diana Naturale, Ludovica Zicarelli, Mariangela Marrelli, Giancarlo Statti, Bruno Tilocca, Paola Roncada, Domenico Britti and Ernesto Palma
Antibiotics 2024, 13(2), 163; https://doi.org/10.3390/antibiotics13020163 - 07 Feb 2024
Cited by 2 | Viewed by 1686
Abstract
Antimicrobial resistance is an increasingly widespread phenomenon that is of particular concern because of the possible consequences in the years to come. The dynamics leading to the resistance of microbial strains are diverse, but certainly include the incorrect use of veterinary drugs both [...] Read more.
Antimicrobial resistance is an increasingly widespread phenomenon that is of particular concern because of the possible consequences in the years to come. The dynamics leading to the resistance of microbial strains are diverse, but certainly include the incorrect use of veterinary drugs both in terms of dosage and timing of administration. Moreover, the drug is often administered in the absence of a diagnosis. Many active ingredients in pharmaceutical formulations are, therefore, losing their efficacy. In this situation, it is imperative to seek alternative treatment solutions. Essential oils are mixtures of compounds with different pharmacological properties. They have been shown to possess the antibacterial, anti-parasitic, antiviral, and regulatory properties of numerous metabolic processes. The abundance of molecules they contain makes it difficult for treated microbial species to develop pharmacological resistance. Given their natural origin, they are environmentally friendly and show little or no toxicity to higher animals. There are several published studies on the use of essential oils as antimicrobials, but the present literature has not been adequately summarized in a manuscript. This review aims to shed light on the results achieved by the scientific community regarding the use of essential oils to treat the main agents of bacterial infection of veterinary interest in livestock. The Google Scholar, PubMed, SciELO, and SCOPUS databases were used for the search and selection of studies. The manuscript aims to lay the foundations for a new strategy of veterinary drug use that is more environmentally friendly and less prone to the emergence of drug resistance phenomena. Full article
(This article belongs to the Special Issue Essential Oil and Plant Extracts: Chemical Composition and Antimicrobial Activity)
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