Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.5
4.8
Journals
Antibiotics
Special Issues
Strategies to Boost Antibiotic Activity
share announcement

Strategies to Boost Antibiotic Activity

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 5584

Special Issue Editors

Prof. Dr. Débora C. Coraça-Huber

E-Mail Website
Guest Editor
Research Laboratory for Biofilms and Implant Associated Infections (BIOFILM LAB), Experimental Orthopedics, Department of Orthopedic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria
Interests: biofilms; implant-infections; antimicrobials; local delivery systems
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Eliana Aparecida de Rezende Duek

E-Mail Website
Guest Editor
Department of Physiological Sciencesb, Faculty of Medical and Health Sciences, Pontifical Catholic University of São Paulo, Sorocaba, SP, Brazil
Interests: biomedical engineering; biomaterials; polimers; local delivery systems
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Marina Angélica Marciano da Silva

E-Mail Website
Guest Editor
Department of Restorative Dentistry, School of Dentistry of Piracicaba, State University of Campinas - FOP/UNICAMP, Piracicaba, SP, Brazil
Interests: dental medicine; bone cements; endodontics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

In conventional medicine, the aim of an acute treatment, during an infection, is the reduction in or the complete elimination of the invading pathogen via the administration of an antimicrobial substance, enabling the host immune system to resolve the infection and repair the affected tissue on its own. An interesting fact is that not all individuals react equally to an infectious pathogen. The outcomes of pathogen colonization and the development of clinical infection can be strictly related to the general health status of a patient. The World Health Organization (WHO) defined “health” as a state of complete physical, mental and social well-being, not merely the absence of disease. Not only the clinical signs of a disease but also the existence of comorbidities such as metabolic syndromes, hormonal disbalances, the presence of silent, chronic inflammations and underlying deficiencies in vitamins, minerals and trace elements can influence the body’s metabolism and the capacity of an organism to fight pathogens. Additionally, the quality of life of a patient may influence their susceptibility to infections. It is known that nutrition, stress and physical activity levels also influence the immune system. Research into and the development of novel antibiotics and antimicrobials, as well as the development of alternatives to conventional substances, are extremely important. However, should we not start considering the general health status of a patient more regularly prior to any type of treatment? Global approaches for improving the health status of a patient prior to surgical implantations (those that can be planned in advance) could strengthen organisms and guarantee more successful healing. Nutritional orientation, stress control, physical activity and weight loss could be examples of such measures. There is an urgent need to investigate measures and alternatives to the use of antibiotic substances, or even substances and general health status improvement strategies for boosting antibiotic activity in case their use is necessary. This Special Issue seeks manuscript submissions that further investigate these strategies. Submissions on the subject of antibiotic-boosting substances, natural antimicrobials and new antimicrobial substances are especially encouraged. Additionally, manuscripts on the subject of measures to improve patients’ global health status, such as nutrition, stress control and lifestyle changes, are encouraged.

Prof. Dr. Débora C. Coraça-Huber
Prof. Dr. Eliana Aparecida de Rezende Duek
Prof. Dr. Marina Angélica Marciano da Silva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Immune system
  • Natural antibiotics
  • Stress control
  • Antibiotics
  • Infections
  • Global health status
  • Nutrition
  • Lifestyle
  • Mindset

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

16 pages, 1927 KiB  
Article
Lyophilized Human Bone Allograft as an Antibiotic Carrier: An In Vitro and In Vivo Study
by Débora C. Coraça-Huber, Stephan J. M. Steixner, Stevo Najman, Sanja Stojanovic, Ronja Finze, Denis Rimashevskiy, Dina Saginova, Mike Barbeck and Reinhard Schnettler
Antibiotics 2022, 11(7), 969; https://doi.org/10.3390/antibiotics11070969 - 19 Jul 2022
Cited by 2 | Viewed by 2133
Abstract
Background: Antibiotics delivered from implanted bone substitute materials (BSM) can potentially be used to prevent acute infections and biofilm formation, providing high concentrations of antibiotics at the surgical site without systemic toxicity. In addition, BSM should allow osteoconductivity supporting bone healing without [...] Read more.
Background: Antibiotics delivered from implanted bone substitute materials (BSM) can potentially be used to prevent acute infections and biofilm formation, providing high concentrations of antibiotics at the surgical site without systemic toxicity. In addition, BSM should allow osteoconductivity supporting bone healing without further surgery. Promising results have been achieved using lyophilized bone allografts mixed with antibiotics. Methods: In this study specially prepared human bone allografts were evaluated as an antibiotic carrier in vitro and in vivo. The efficacy of different antibiotic-impregnated bone allografts was measured by drug release tests in vitro and in vivo and bacterial susceptibility tests using four bacterial species usually responsible for implant-associated infections. Results: The loading procedures of allograft bone substitutes with antibiotics were successful. Some of the antibiotic concentrations exceeded the MIC90 for up to 7 days in vitro and for up to 72 h in vivo. The susceptibility tests showed that S. epidermidis ATCC 12228 was the most susceptible bacterial species in comparison to the other strains tested for all antibiotic substances. Vancomycin and rifampicin showed the best results against standard and patient-isolated strains in vitro. In vivo, new bone formation was comparable in all study groups including the control group without antibiotic loading. Conclusions: Human bone allografts showed the capacity to act as customized loaded antibiotic carriers to prevent acute infections and should be considered in the management of bone infections in combination with systemic antimicrobial therapy. Full article
(This article belongs to the Special Issue Strategies to Boost Antibiotic Activity)
►▼ Show Figures

Figure 1

15 pages, 2656 KiB  
Article
Levofloxacin Cocrystal/Salt with Phthalimide and Caffeic Acid as Promising Solid-State Approach to Improve Antimicrobial Efficiency
by Noor Ul Islam, Muhammad Naveed Umar, Ezzat Khan, Fakhria A. Al-Joufi, Shaymaa Najm Abed, Muhammad Said, Habib Ullah, Muhammad Iftikhar, Muhammad Zahoor and Farhat Ali Khan
Antibiotics 2022, 11(6), 797; https://doi.org/10.3390/antibiotics11060797 - 13 Jun 2022
Cited by 12 | Viewed by 2567
Abstract
To overcome the issue of multidrug resistant (MDR) microbes, the exploration of ways to improve the antimicrobial efficiency of existing antibiotics is one of the promising approaches. In search of synthons with higher efficiency, in current investigations, cocrystal and amorphous salt of levofloxacin [...] Read more.
To overcome the issue of multidrug resistant (MDR) microbes, the exploration of ways to improve the antimicrobial efficiency of existing antibiotics is one of the promising approaches. In search of synthons with higher efficiency, in current investigations, cocrystal and amorphous salt of levofloxacin hemihydrate (LEV) were developed with phthalimide (PTH) and caffeic acid (CFA). New materials were characterized with the help of FT-IR, Raman spectroscopy, powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Shifting, attenuation, appearance/disappearance and broadening of bands were observed in the FT-IR and Raman spectra of the materials as evidence of the required product. The PXRD diffraction pattern observed for LEV-PTH indicated cocrystal while halo diffractogram of LEV-CFA revealed amorphous nature. DSC/TG analysis confirmed the hydrated nature of the cocrystal/salt. The dissolution rate and antimicrobial activity against selected strains, K.pneumonia, E. coli and S. typhi of parent drug and the new material were compared. The zone of inhibition (ZI) observed for 5 µg LEV-PTH was 30.4 + 0.36 (K. pneumonia), 26.33 + 0.35 (E. coli) and 30.03 + 0.25 mm (S. typhi) while LEV-CFA salt (5 µg) against the same strains inhibited 33.96 ± 0.25, 31.66 ± 0.35 and 27.93 ± 0.40 mm, respectively. These novel formulations enhance the dissolution rate as well as antibacterial efficiency and are expected to be potent against MDR bacterial strains. Full article
(This article belongs to the Special Issue Strategies to Boost Antibiotic Activity)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop