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Antibiotics
Special Issues
Antimicrobial Nanoformulations against Bacterial Infections
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Antimicrobial Nanoformulations against Bacterial Infections

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Materials and Surfaces".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 3420

Special Issue Editor

Dr. Akhilesh Rai

E-Mail Website
Guest Editor
CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
Interests: antimicrobial nanoformulation; antimicrobial peptides; antimicrobial resistance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Multidrug-resistant bacteria pose a major threat to human health, causing prominent economic and healthcare burdens to patients. MDR bacteria cause more than 3 million infections annually in the USA alone, leading to 35000 deaths. The generation of MDR bacteria also impacts the clinical outcomes of cancer therapy, transplantation, and surgical procedures. Without serious and coordinated efforts globally, MDR bacteria may rampantly kill people during infections as antibiotics will not be active to combat them. Therefore, it is important to develop alternative formulations to combat MDR bacterial infections.

Various compositions of nanoparticles (NPs) with an inherent antimicrobial property or loaded with antimicrobial agents such as antibiotics, antimicrobial peptides, and small cationic molecules are developed to effectively kill bacteria and eliminate biofilms. Additionally, these NPs are also explored to evaluate the therapeutic efficacy of animal models. Besides NPs, hydrogels containing antimicrobial agents, photothermal energy-generating NPs, and photodynamic therapy are extensively used to treat various infections.

The Special Issue aims to highlight the current research efforts in the design of antimicrobial nanoformulations for the treatment of infectious diseases in vitro and animal models. Moreover, this Issue will focus on the synthesis of antimicrobial NPs and hydrogels and their antimcirobial efficacy in killing wide strains of Gram-positive and Gram-negative bacteria. Other topics include the synergistic antimicrobial action of NPs combined with antibiotics, antimicrobial peptides, cationic molecules, photothermal therapy, and photodynamic therapy.

On behalf of Antibiotics, you are cordially invited to contribute an article to the Special Issue “Antimicrobial Nanoformulations against Bacterial Infections”. Research articles, reviews, and mini-reviews are welcome.

Dr. Akhilesh Rai
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial peptide-NPs
  • antibiotics-coated NPs
  • antimicrobial hydrogel
  • antimicrobial photoresponsive NPs
  • antimicrobial photodynamic therapy
  • infection

Published Papers (2 papers)

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Research

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18 pages, 3528 KiB  
Article
Gatifloxacin Loaded Nano Lipid Carriers for the Management of Bacterial Conjunctivitis
by Poorva H. Joshi, Ahmed Adel Ali Youssef, Mihir Ghonge, Corinne Varner, Siddharth Tripathi, Narendar Dudhipala and Soumyajit Majumdar
Antibiotics 2023, 12(8), 1318; https://doi.org/10.3390/antibiotics12081318 - 15 Aug 2023
Cited by 2 | Viewed by 1413
Abstract
Bacterial conjunctivitis (BC) entails inflammation of the ocular mucous membrane. Early effective treatment of BC can prevent the spread of the infection to the intraocular tissues, which could lead to bacterial endophthalmitis or serious visual disability. In 2003, gatifloxacin (GTX) eyedrops were introduced [...] Read more.
Bacterial conjunctivitis (BC) entails inflammation of the ocular mucous membrane. Early effective treatment of BC can prevent the spread of the infection to the intraocular tissues, which could lead to bacterial endophthalmitis or serious visual disability. In 2003, gatifloxacin (GTX) eyedrops were introduced as a new broad-spectrum fluoroquinolone to treat BC. Subsequently, GTX use was extended to other ocular bacterial infections. However, due to precorneal loss and poor ocular bioavailability, frequent administration of the commercial eyedrops is necessary, leading to poor patient compliance. Thus, the goal of the current investigation was to formulate GTX in a lipid-based drug delivery system to overcome the challenges with the existing marketed eyedrops and, thus, improve the management of bacterial conjunctivitis. GTX-NLCs and SLNs were formulated with a hot homogenization–probe sonication method. The lead GTX-NLC formulation was characterized and assessed for in vitro drug release, antimicrobial efficacy (against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa), and ex vivo permeation. The lead formulation exhibited desired physicochemical characteristics, an extended release of GTX over a 12 h period, and was stable over three months at the three storage conditions (refrigerated, room temperature, and accelerated). The transcorneal flux and permeability of GTX from the GTX-NLC formulation were 5.5- and 6.0-fold higher in comparison to the commercial eyedrops and exhibited a similar in vitro antibacterial activity. Therefore, GTX-NLCs could serve as an alternative drug delivery platform to improve treatment outcomes in BC. Full article
(This article belongs to the Special Issue Antimicrobial Nanoformulations against Bacterial Infections)
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Review

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23 pages, 2172 KiB  
Review
Recent Advances in the Development of Antibiotics-Coated Gold Nanoparticles to Combat Antimicrobial Resistance
by Partha Pratim Sarma, Akhilesh Rai and Pranjal K. Baruah
Antibiotics 2024, 13(2), 124; https://doi.org/10.3390/antibiotics13020124 - 26 Jan 2024
Cited by 1 | Viewed by 1642
Abstract
Antimicrobial resistance (AMR) has become an alarming threat to the successful treatment of rapidly growing bacterial infections due to the abuse and misuse of antibiotics. Traditional antibiotics bear many limitations, including restricted bioavailability, inadequate penetration and the emergence of antimicrobial-resistant microorganisms. Recent advances [...] Read more.
Antimicrobial resistance (AMR) has become an alarming threat to the successful treatment of rapidly growing bacterial infections due to the abuse and misuse of antibiotics. Traditional antibiotics bear many limitations, including restricted bioavailability, inadequate penetration and the emergence of antimicrobial-resistant microorganisms. Recent advances in nanotechnology for the introduction of nanoparticles with fascinating physicochemical characteristics have been predicted as an innovative means of defence against antimicrobial-resistant diseases. The use of nanoparticles provides several benefits, including improved tissue targeting, better solubility, improved stability, enhanced epithelial permeability and causes minimal side effects. However, except for gold nanoparticles (AuNPs), the biological safety of the majority of metal nanoparticles remains a serious problem. AuNPs appear to be promising for drug delivery and medicinal applications because of their minimal toxicity, biocompatibility, functional flexibility, chemical stability and versatile biological activities, such as their antiviral, antifungal, anti-inflammatory and antimicrobial properties. Hence, we are focusing on the gold nanoparticles possessing antimicrobial activity in this article. This review will cover recent strategies in the preparation of gold nanoparticles, with special emphasis placed on antibiotics-coated AuNPs with enhanced antimicrobial properties and how they fight against disease-causing bacteria and eradicate biofilms, along with their activities and physicochemical properties. Full article
(This article belongs to the Special Issue Antimicrobial Nanoformulations against Bacterial Infections)
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