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Antibiotics
Special Issues
Fight against Antimicrobial Resistance: The Innovative Strategies
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Fight against Antimicrobial Resistance: The Innovative Strategies

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics Use and Antimicrobial Stewardship".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 2517

Special Issue Editor

Prof. Dr. Qiang Sun

E-Mail Website
Guest Editor
1. Center for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
2. NHC Key Lab of Health Economics and Policy Research, Shandong University, Jinan 250012, China
Interests: health economics; health policy; public health; antimicrobial resistance

Special Issue Information

Dear Colleagues,

Antimicrobial resistance (AMR) has become a significant threat to global public health across the human, animal, plant, food, and environmental sectors, resulting in the delayed application of effective interventions, as well as increased mortality, morbidity, and costs. Currently, to restrain AMR, the United Nations is promoting a One Health approach. One Health addresses the relationships between human, animal, and environmental health, emphasizing that efforts must be made across all these sectors. Therefore, there is an urgent need to develop and implement cross-disciplinary and coordinated multi-faceted strategies (interventions) to curb bacterial resistance. Meanwhile, cross-departmental strategies should also be further strengthened for playing a more active role in fighting AMR.

In this Special Issue, we will present innovative strategies to fight AMR from a One Health perspective, for which interdisciplinary cooperations are between the epidemiology, antimicrobial stewardship, and specific interventions across health and computer science sectors. We welcome contributions that address any of the above topics.

Prof. Dr. Qiang Sun
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance
  • One Health
  • antibiotics
  • innovative strategies
  • intervention

Published Papers (2 papers)

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Research

12 pages, 518 KiB  
Article
Risk Factors Associated with Mortality in Acinetobacter baumannii Infections: Results of a Prospective Cohort Study in a Tertiary Public Hospital in Guayaquil, Ecuador
by Luz Abarca-Coloma, Miguel Puga-Tejada, Tamara Nuñez-Quezada, Otilia Gómez-Cruz, Carlos Mawyin-Muñoz, Shivan Barungi and Macarena Perán
Antibiotics 2024, 13(3), 213; https://doi.org/10.3390/antibiotics13030213 - 23 Feb 2024
Viewed by 993
Abstract
Antibiotic overuse and the resulting antimicrobial resistance pose significant global public health challenges, providing an avenue for opportunistic pathogens like Acinetobacter baumannii to thrive. This study will report the trends of Acinetobacter baumannii antimicrobial resistance patterns at the Hospital Teodoro Maldonado Carbo, Ecuador. [...] Read more.
Antibiotic overuse and the resulting antimicrobial resistance pose significant global public health challenges, providing an avenue for opportunistic pathogens like Acinetobacter baumannii to thrive. This study will report the trends of Acinetobacter baumannii antimicrobial resistance patterns at the Hospital Teodoro Maldonado Carbo, Ecuador. An observational, analytical, longitudinal, and prospective study was conducted involving patients diagnosed with hospital-acquired infections. Antimicrobial susceptibility testing was performed, followed by molecular analysis of carbapenemase genes in Acinetobacter baumannii isolates. We included 180 patients aged from 16 to 93 years. The hospital mortality rate was 63/180 (35%). Invasive mechanical ventilation (IMV) was indicated in 91/180 patients (50.4%). The overall survival (OS) rate in patients on IMV was 49.5% (45/91), with a median survival of 65 days. The OS rate in patients not on IMV was 80.9% (72/89), with a median survival of 106 days (HR 2.094; 95% CI 1.174–3.737; p = 0.012). From multivariate analysis, we conclude that ventilator-associated pneumonia is the most related factor to OS. Full article
(This article belongs to the Special Issue Fight against Antimicrobial Resistance: The Innovative Strategies)
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16 pages, 292 KiB  
Article
Clinical Uncertainty Influences Antibiotic Prescribing for Upper Respiratory Tract Infections: A Qualitative Study of Township Hospital Physicians and Village Doctors in Rural Shandong Province, China
by Liyan Shen, Ting Wang, Jia Yin, Qiang Sun and Oliver James Dyar
Antibiotics 2023, 12(6), 1027; https://doi.org/10.3390/antibiotics12061027 - 08 Jun 2023
Cited by 1 | Viewed by 1211
Abstract
Objective: This study aimed to explore how clinical uncertainty influences antibiotic prescribing practices among township hospital physicians and village doctors in rural Shandong Province, China. Methods: Qualitative semi-structured interviews were conducted with 30 township hospital physicians and 6 village doctors from rural Shandong [...] Read more.
Objective: This study aimed to explore how clinical uncertainty influences antibiotic prescribing practices among township hospital physicians and village doctors in rural Shandong Province, China. Methods: Qualitative semi-structured interviews were conducted with 30 township hospital physicians and 6 village doctors from rural Shandong Province, China. A multi-stage random sampling method was used to identify respondents. Conceptual content analysis together with Colaizzi’s method were used to generate qualitative codes and identify themes. Results: Three final thematic categories emerged during the data analysis: (1) Incidence and treatment of Upper Respiratory Tract Infections (URTIs) in township hospitals and village clinics; (2) Antibiotic prescribing practices based on the clinical experience of clinicians; (3) Influence of clinical uncertainty on antibiotic prescribing. Respondents from both township hospitals and village clinics reported that URTIs were the most common reason for antibiotic prescriptions at their facilities and that clinical uncertainty appears to be an important driver for the overuse of antibiotics for URTIs. Clinical uncertainty was primarily due to: (1) Diagnostic uncertainty (establishing a relevant diagnosis is hindered by limited diagnostic resources and capacities, as well as limited willingness of patients to pay for investigations), and (2) Insufficient prognostic evidence. As a consequence of the clinical uncertainty caused by both diagnostic and prognostic uncertainty, respondents stated that antibiotics are frequently prescribed for URTIs to prevent both prolonged courses or recurrence of the disease, as well as clinical worsening, hospital admission, or complications. Conclusion: Our study suggests that clinical uncertainty is a key driver for the overuse and misuse of prescribing antibiotics for URTIs in both rural township hospitals and village clinics in Shandong province, China, and that interventions to reduce clinical uncertainty may help minimize the unnecessary use of antibiotics in these settings. Interventions that use clinical rules to identify patients at low risk of complications or hospitalization may be more feasible in the near-future than laboratory-based interventions aimed at reducing diagnostic uncertainty. Full article
(This article belongs to the Special Issue Fight against Antimicrobial Resistance: The Innovative Strategies)
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