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Antibiotics
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Local Antibiotics: Antibiotic Loaded Bone Cement and Drug Containing Medical...
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Local Antibiotics: Antibiotic Loaded Bone Cement and Drug Containing Medical Devices in Orthopaedic Surgery

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics Use and Antimicrobial Stewardship".

Deadline for manuscript submissions: closed (30 March 2024) | Viewed by 1983

Special Issue Editors

Prof. Dr. Christian O. Fölsch

E-Mail Website
Guest Editor
1. Universitätsklinikum Gießen und Marburg, Gießen, Germany
2. Klinik für Orthopädie und Orthopädische Chirurgie, Klinikstraße 33, Gießen, Germany
Interests: biomaterials; arthroplasty; antibiotics in revision surgery
Dr. Klaus Dieter Kühn

E-Mail Website
Guest Editor
Department of Orthopaedics and Orthopaedic Surgery, Medical University Graz, Auenbruggerplatz 34, 8036 Graz, Austria
Interests: antibiotics

Special Issue Information

Dear Colleagues,

The increasing number of joint replacements worldwide leads to more infections of implants. Biofilm and antibiotic resistance still make the prevention and treatment of implant-associated infections challenging. The improvement of diagnostic procedures for the early detection of infections is important to improve outcomes and avoid the removal of implants.

Depending on the clinical situation and the bacterial detection, the treatment of choice might be the primary change of an implant, or a two-stage procedure is performed. Different regimes of antibiotic treatment are proposed, since the duration and choice of antibiotic application remain controversial.

Immediate antibiotic treatment is necessary to prevent biofilm formation. A combined systemic antibiotic treatment as well as the local application of antibiotics and antibacterial substances might improve the outcomes of infected implants. For two-stage revisions of joint replacements, the application of a cement spacer, including antibiotics, is established. The combination of several antibiotics and the dose applied are relevant for the antimicrobial effect, since their influence on the mechanic stability of the cement has to be considered. The duration of antibiotic treatment should be performed individually.

Prof. Dr. Christian O. Fölsch
Dr. Klaus Dieter Kühn
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biofilm
  • antibiotic resistance
  • implant-associated infections
  • local antibiotic application
  • cement spacer
  • antibacterial substances
  • antibiotic carrier

Published Papers (2 papers)

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Research

24 pages, 3326 KiB  
Article
Impact of Anti-Mycotic Drugs on the Osteogenic Response of Bone Marrow Mesenchymal Stem Cells In Vitro
by Tim Niklas Bewersdorf, Jakob Hofmann, Sebastian Findeisen, Christian Schamberger, Thomas Lingner, Ulrike Sommer, Gerhard Schmidmaier and Tobias Grossner
Antibiotics 2024, 13(2), 186; https://doi.org/10.3390/antibiotics13020186 - 15 Feb 2024
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Abstract
The treatment of fungal bone infections and infected non-unions is a huge challenge in modern trauma and orthopedics, which normally contain the local and systemic administration of anti-fungal drugs. Although frequently used, little is known about the impact of systemic and locally administered [...] Read more.
The treatment of fungal bone infections and infected non-unions is a huge challenge in modern trauma and orthopedics, which normally contain the local and systemic administration of anti-fungal drugs. Although frequently used, little is known about the impact of systemic and locally administered fungicides on the osteogenic regenerative capabilities of infected bone tissue, especially upon the osteogenesis of human bone marrow mesenchymal stem cells (BM-hMSCs). This study evaluates the effects of the three most common fungicides for the systemic treatment of bone infections, Voriconazole (VOR), liposomal Amphotericin B (LAMB), and Fluconazole (FLU), as well as the effects of VOR and LAMB-loaded Polymethylmethacrylate (PMMA) cement chips in different concentrations upon the osteogenic response of BM-hMSCs in vitro. Within this study, we compared the ability of BM-hMSC to differentiate into osteoblast-like cells and synthesize hydroxyapatite as assessed by radioactive 99mTechnetium-Hydroxydiphosphonate (99mTc-HDP) labeling, cell proliferation, and analyses of supernatants upon various osteogenic parameters. Our results revealed that VOR added to the cell culture medium affects the osteogenic potential of BM-hMSC negatively, while there were no detectable effects of LAMB and FLU. Moreover, we showed dose-dependent negative effects of high- and extended-dose fungicide-loaded PMMA cement due to cytotoxicity, with a higher cytotoxic potential of VOR than LAMB, while low-dose fungicide-loaded PMMA had no significant effect on the osteogenic potential of BM-hMSC in vitro. Full article
(This article belongs to the Special Issue Local Antibiotics: Antibiotic Loaded Bone Cement and Drug Containing Medical Devices in Orthopaedic Surgery)
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14 pages, 3390 KiB  
Article
Impact of Antibiotic-Loaded PMMA Spacers on the Osteogenic Potential of hMSCs
by Jakob Hofmann, Tim Niklas Bewersdorf, Ulrike Sommer, Thomas Lingner, Sebastian Findeisen, Christian Schamberger, Gerhard Schmidmaier and Tobias Großner
Antibiotics 2024, 13(1), 44; https://doi.org/10.3390/antibiotics13010044 - 03 Jan 2024
Viewed by 897
Abstract
Antibiotic-loaded PMMA bone cement is frequently used in modern trauma and orthopedic surgery. Although many of the antibiotics routinely applied are described to have cytotoxic effects in the literature, clinical experience shows no adverse effects for bone healing. To determine the effects of [...] Read more.
Antibiotic-loaded PMMA bone cement is frequently used in modern trauma and orthopedic surgery. Although many of the antibiotics routinely applied are described to have cytotoxic effects in the literature, clinical experience shows no adverse effects for bone healing. To determine the effects of antibiotic-loaded PMMA spacers on osteogenesis in vitro, we cultivated human bone marrow mesenchymal stem cells (BM-hMSCs) in the presence of PMMA spacers containing Gentamicin, Vancomycin, Gentamicin + Clindamycin as well as Gentamicin + Vancomycin in addition to a blank control (agarose) and PMMA containing no antibiotics. The cell number was assessed with DAPI staining, and the osteogenic potential was evaluated by directly measuring the amount of hydroxyapatite synthesized using radioactive 99mTc-HDP labelling as well as measuring the concentration of calcium and phosphate in the cell culture medium supernatant. The results showed that Gentamicin and Vancomycin as well as their combination show a certain amount of cytotoxicity but no negative effect on osteogenic potential. The combination of Gentamicin and Clindamycin, on the other hand, led to a drastic reduction in both the cell count and the osteogenic potential. Full article
(This article belongs to the Special Issue Local Antibiotics: Antibiotic Loaded Bone Cement and Drug Containing Medical Devices in Orthopaedic Surgery)
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