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Volume 78
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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.

Adv. Respir. Med., Volume 78, Issue 6 (October 2010) – 16 articles , Pages 379-465

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138 KiB  
Editorial
Od redakcji
by Pneumonologia i Alergologia Polska Editorial Office
Adv. Respir. Med. 2010, 78(6), 464-465; https://doi.org/10.5603/ARM.27706 - 29 Oct 2010
Viewed by 230
Abstract
Od Zjazdu Towarzystwa w Mikołajkach obejmuję stanowisko Pre-zesa Polskiego Towarzystwa Chorób Płuc [...] Full article
50 KiB  
Editorial
List of Reviewers 2010 Year
by Pneumonologia i Alergologia Polska Editorial Office
Adv. Respir. Med. 2010, 78(6), 462-463; https://doi.org/10.5603/ARM.27705 - 29 Oct 2010
Viewed by 253
Abstract
List of reviewers 2010 year [...] Full article
132 KiB  
Editorial
Visions in Addiction Medicine—Also for Pneumonologists?
by Albrecht Ulmer
Adv. Respir. Med. 2010, 78(6), 458-461; https://doi.org/10.5603/ARM.27707 - 29 Oct 2010
Viewed by 278
Abstract
My invitation as a physician for addictionmedicine from Germany certainly seems somewhatcurious to you [...] Full article
100 KiB  
Letter
Wolność wyboru to także odpowiedzialność za nieszkodzenie innym
by Jerzy Kozielski
Adv. Respir. Med. 2010, 78(6), 456-457; https://doi.org/10.5603/ARM.27704 - 29 Oct 2010
Viewed by 247
Abstract
Rozpowszechnienie nałogu palenia tytoniu,datowane od początku ubiegłego stulecia, zmieni-ło postać i częstość występowania związanychz nim chorób [...] Full article
67 KiB  
Editorial
“Advances in Pneumonology”—Over 20 Years Long Tradition
by Pneumonologia i Alergologia Polska Editorial Office
Adv. Respir. Med. 2010, 78(6), 454-455; https://doi.org/10.5603/ARM.27701 - 29 Oct 2010
Viewed by 244
Abstract
“Advances in Pneumonology”—Over 20 Years Long Tradition [...] Full article
355 KiB  
Editorial
Sesja Polskiego Towarzystwa Chorób Płuc z okazji setnej rocznicy śmierci Roberta Kocha
by Tadeusz M. Zielonka
Adv. Respir. Med. 2010, 78(6), 451-453; https://doi.org/10.5603/ARM.27700 - 29 Oct 2010
Viewed by 229
Abstract
Dla uczczenia rocznicy ogłoszenia przez Rober-ta Kocha odkrycia prątków gruźlicy Światowa Orga-nizacja Zdrowia (WHO, World Health Organization) ogłosiła 24 marca Dniem Walki z Gruźlicą [...] Full article
431 KiB  
Case Report
Primary Sjögren’s Syndrome with Two Extraglandular Sites Involvement—Case Report
by Monika Szturmowicz, Ewelina Wilińska, Anna Paczek, Liliana Wawrzyńska, Lucyna Opoka, Juliusz Gątarek, Renata Langfort, Ewa Rowińska-Zakrzewska and Adam Torbicki
Adv. Respir. Med. 2010, 78(6), 445-450; https://doi.org/10.5603/ARM.27697 - 29 Oct 2010
Viewed by 244
Abstract
Pierwotny zespół Sjögrena (pSS) jest przewlekłą postępującą chorobą zapalną o podłożu autoimmunologicznym, charakteryzującą się naciekiem limfocytarnym gruczołów wydzielania zewnętrznego, który prowadzi do zmniejszenia funkcji wydzielniczej tych gruczołów i w konsekwencji—do zespołu suchości. U 40–60% chorych dochodzi do rozwoju pozagruczołowych objawów choroby. W pracy [...] Read more.
Pierwotny zespół Sjögrena (pSS) jest przewlekłą postępującą chorobą zapalną o podłożu autoimmunologicznym, charakteryzującą się naciekiem limfocytarnym gruczołów wydzielania zewnętrznego, który prowadzi do zmniejszenia funkcji wydzielniczej tych gruczołów i w konsekwencji—do zespołu suchości. U 40–60% chorych dochodzi do rozwoju pozagruczołowych objawów choroby. W pracy opisano przypadek chorej na pierwotny zespół Sjögrena, przebiegający z zajęciem płuc i układu pokarmowego. Full article
223 KiB  
Review
Konsolidujące leczenie systemowe w zaawansowanym niedrobnokomórkowym raku płuca
by Renata Duchnowska
Adv. Respir. Med. 2010, 78(6), 439-444; https://doi.org/10.5603/ARM.27699 - 29 Oct 2010
Viewed by 291
Abstract
Standardowym postępowaniem w zaawansowanym niedrobnokomórkowym raku płuca jest paliatywna chemioterapia, ale jej wyniki nie są zadowalające. W większości przypadków przeprowadza się kilka cykli leczenia, ponieważ nie ma dowodów, że przedłużanie go przynosi istotną kliniczną korzyść. W ostatnich latach duże zainteresowanie wzbudziło nowe podejście [...] Read more.
Standardowym postępowaniem w zaawansowanym niedrobnokomórkowym raku płuca jest paliatywna chemioterapia, ale jej wyniki nie są zadowalające. W większości przypadków przeprowadza się kilka cykli leczenia, ponieważ nie ma dowodów, że przedłużanie go przynosi istotną kliniczną korzyść. W ostatnich latach duże zainteresowanie wzbudziło nowe podejście do leczenia podtrzymującego, polegające na jego kontynuowaniu z użyciem leków cytotoksycznych o udowodnionej skuteczności w II linii leczenia, takich jak docetaksel i pemetreksed lub leków molekularnie ukierunkowanych (erlotynib, gefitynib, cetuksymab i bewacyzumab). W pracy przedstawiono obecny stan wiedzy dotyczący tej strategii leczniczej, uwzględniający wyniki najważniejszych badań klinicznych z losowym doborem chorych oraz ich metaanaliz. Full article
198 KiB  
Review
Searching for Genes Influencing Tobacco Smoking Susceptibility
by Pneumonologia i Alergologia Polska Editorial Office
Adv. Respir. Med. 2010, 78(6), 432-438; https://doi.org/10.5603/ARM.27698 - 29 Oct 2010
Viewed by 246
Abstract
Numerous studies indicate genetical background of susceptibility to tobacco smoking. The current review presents new achievements and perspectives in searching for genes involved in tobacco smoking and dependence, which have been described in recent years as a result of the development of molecular [...] Read more.
Numerous studies indicate genetical background of susceptibility to tobacco smoking. The current review presents new achievements and perspectives in searching for genes involved in tobacco smoking and dependence, which have been described in recent years as a result of the development of molecular techniques. It has been emphasized that tobacco smoking is a complex, polygenic behavior. Presence of multiple gene-gene and gene-environment interactions makes it difficult to find a strong genetic association. The causes of inconsistency in the results of candidate gene association studies, as well as the new perspectives in searching for genetic determinants of tobacco smoking, are also widely discussed. In particular, the focus is on the genome-wide association studies which allow the complex analysis of links between thousands of single nucleotide polymorphisms with smoking phenotypes. Full article
187 KiB  
Guidelines
Updated Recommendations on Systemic Treatment of Non-Small Cell Lung Cancer and Malignant Pleural Mesothelioma
by Jacek Jassem, Wojciech Biernat, Kazimierz Drosik, Rafał Dziadziuszko, Radzisław Kordek, Jerzy Kozielski, Dariusz M. Kowalski, Maciej Krzakowski, Jacek Nikliński, Włodzimierz Olszewski, Tadeusz Orłowski, Rodryg Ramlau, Kazimierz Roszkowski-Śliż and Witold Rzyman
Adv. Respir. Med. 2010, 78(6), 418-431; https://doi.org/10.5603/ARM.27703 - 29 Oct 2010
Viewed by 254
Abstract
Updated recommendations on systemic treatment of non-small cell lung cancer and malignant pleural mesothelioma [...] Full article
205 KiB  
Guidelines
Nowa klasyfikacja TNM w raku płuca
by Anna Wrona and Jacek Jassem
Adv. Respir. Med. 2010, 78(6), 407-417; https://doi.org/10.5603/ARM.27702 - 29 Oct 2010
Cited by 4 | Viewed by 377
Abstract
W pracy omówiono nową klasyfikację TNM w raku płuca oraz przedstawiono jej historię. Siódme wydanie klasyfikacji TNM raka płuca zostało opublikowane na początku 2009 roku przez Międzynarodową Unię do Walki z Rakiem (UICC) i Amerykański Wspólny Komitet Raka (AJCC). Wprowadzone zmiany opierają się [...] Read more.
W pracy omówiono nową klasyfikację TNM w raku płuca oraz przedstawiono jej historię. Siódme wydanie klasyfikacji TNM raka płuca zostało opublikowane na początku 2009 roku przez Międzynarodową Unię do Walki z Rakiem (UICC) i Amerykański Wspólny Komitet Raka (AJCC). Wprowadzone zmiany opierają się na wynikach analiz danych zgromadzonych w ramach międzynarodowego projektu zrealizowanego przez Międzynarodowe Towarzystwo do Badań nad Rakiem Płuca (IASLC). Do bazy danych włączono 81 495 chorych z całego świata (68 463 z rozpoznaniem raka niedrobnokomórkowego i 13,032—raka drobnokomórkowego) leczonych różnymi metodami w latach 1990–2000. Zebrane dane poddano zewnętrznej i wewnętrznej walidacji. Wielkość guza uznano za czynnik rokowniczy: guzy T1 podzielono na podkategorie T1a (≤ 2 cm) i T1b (> 2 cm–≤ 3 cm), guzy T2 na T2a (> 3 cm–≤ 5 cm) i T2b (> 5 cm–≤ 7 cm), a guzy > 7 cm włączono do kategorii T3. Obecność dodatkowych guzków nowotworowych w tym samym płacie co guz pierwotny zakwalifikowano do cechy T3, a w innym płacie, ale po tej samej stronie—do T4. Nie dokonano zmian w klasyfikacji cechy N. Cechę M1 podzielono na podkategorie M1a (dodatkowe guzki nowotworowe w drugim płucu, rozsiew opłucnowy) oraz M1b (przerzuty odległe). Duże guzy T2 (T2bN0M0) przesunięto ze stopnia IB do stopnia IIA, małe guzy T2 (T2aN1M0)—z IIB do IIA, a T4N0-N1M0—ze stopnia IIIB do IIIA. W odniesieniu do drobnokomórkowego raka płuca zalecono stosowanie klasyfikacji TNM zamiast dotychczasowego podziału na postać ograniczoną i rozsianą. Full article
98 KiB  
Article
Immigrants Treated for Tuberculosis in Mazovian Centre of Lung Diseases and Tuberculosis in Otwock
by Jacek Jagodziński and Tadeusz M. Zielonka
Adv. Respir. Med. 2010, 78(6), 399-406; https://doi.org/10.5603/ARM.27696 - 29 Oct 2010
Viewed by 281
Abstract
Introduction: Migrationof population contributes to the transmission of tuberculosis (TB), particularly multidrug-resistant tuberculosis. In the countries of Western Europe, the immigrantsí inflow contributes to the deterioration of the epidemiological situation. Majority of newly detected TB cases in some countries were affirmed among [...] Read more.
Introduction: Migrationof population contributes to the transmission of tuberculosis (TB), particularly multidrug-resistant tuberculosis. In the countries of Western Europe, the immigrantsí inflow contributes to the deterioration of the epidemiological situation. Majority of newly detected TB cases in some countries were affirmed among immigrant and foreign born population. In Poland, this problem has not been investigated up to 2005. The aim of the study was the assessment of the occurrence of tuberculosis in immigrants treated in the Mazovian Centre for Treatment of Lung Diseases and Tuberculosis in Otwock. Material and methods: This work had a retrospective character. The number of cases of tuberculosis in immigrants admitted between 2002 and 2007 was calculated from the data base of theMazovian Centre for Treatment of Lung Diseases and Tuberculosis; 125 patients, whose basic demographic data, bacteriological status and the radiological changes suggested TB, were included in the study. Results: The foreigners made up to 0.5–1.7% all tuberculosis cases treated in Mazovian Centre for Treatment of Lung Diseases and Tuberculosis. Among confirmed cases, twenty four nationalities were seen. Nationals of the Russian Federation (coming from the Republic of Chechnya) formed the biggest group (24%), followed by the Vietnamese (21%) and the Ukrainians (12%). Most of all cases were young men (77%; average age—34 years). Children made up to 12% of all cases. Tuberculosis of the lungs was predominating, and there were culture confirmed extrapulmonary locations in 13.6% of cases. Bacteriological confirmation was achieved in 53% of cases, but up to 22.7% cases were resistant to one of the antituberculosis medicines and 13.6% was multidrug-resistant. Conclusions: Despite the fact, that immigrants made up a small proportion among all the patient treated for tuberculosis in Mazovia, their number systematically increases. High proportion of multidrug-resistant tuberculosis reported in foreign-born cases is a concern. Full article
171 KiB  
Article
Prevalence of Home Mechanical Ventilation in Poland
by Jacek Nasiłowski, Zbigniew Szkulmowski, Marek Migdał, Witalij Andrzejewski, Wojciech Drozd, Małgorzata Czajkowska-Malinowska, Andrzej Opuchlik and Ryszarda Chazan
Adv. Respir. Med. 2010, 78(6), 392-398; https://doi.org/10.5603/ARM.27695 - 29 Oct 2010
Cited by 2 | Viewed by 348
Abstract
Introduction: Home mechanical ventilation (HMV) is increasingly used in the treatment of chronic respiratory failure further to rapid technological development, increasing number of elderly people and extension of indications. The aim of the study was to assess: prevalence of HMV in Poland, [...] Read more.
Introduction: Home mechanical ventilation (HMV) is increasingly used in the treatment of chronic respiratory failure further to rapid technological development, increasing number of elderly people and extension of indications. The aim of the study was to assess: prevalence of HMV in Poland, the proportions of lung disease and neuromuscular patients using HMV and the type of interface (invasive v. non-invasive). Material and methods: The questionnaire was sent to all institutions providing HMV in Poland and to regional departments of National Health System (NHS). Results: All NHS departments responded. They reported 846 HMV users, 31% of whom were children. The prevalence of HMV in Poland was assessed as 2.2 patient per 100.000 population without striking differences between provinces. Among 39 HMV centers in Poland 12 (31%) answered. They reported 206 patients (24% of all HMV users). Proportion of ventilation mode consisted of 59% (122 pts) treated via a tracheostomy and 41% (84 pts) with non invasive ventilation (NIV). 168 patients (82%) had neuromuscular diseases (ND), majority of them muscular dystrophy—57 patients ( 34% of ND) and amyotrophic lateral sclerosis—39 patients (23% of ND). There were only 38 patients (18%) with lung and thoracic cage diseases: 17 with COPD and 10 with kyphoscoliosis. Conclusions: The prevalence of HMV treatment in Poland has developed dramatically in the last decade, but is still very low comparing to other European countries, especially due to very low number of patients with lung and chest wall diseases. The prevalence of invasive mode of ventilation is extremely high. The most important factors which inhibit development of HMV in Poland are: omission of respiratory physicians in the process of qualification, lack of national guidelines, sophisticated demands for HMV providers. The awareness of the need of HMV especially in patients with respiratory failure due to obesity hypoventilation syndrome and restrictive lung diseases should be increased among chest physicians.
Full article
151 KiB  
Article
The Results of Molecular Epidemiologic Investigations in Patients Infected with Strains of the Genus Acinetobacter
by Joanna Nowak, Agnieszka Pacholczyk, Violetta Petroniec, Beata Dziedzicka and Zofia Zwolska
Adv. Respir. Med. 2010, 78(6), 386-391; https://doi.org/10.5603/ARM.27694 - 29 Oct 2010
Cited by 1 | Viewed by 325
Abstract
Introduction: Acinetobacter spp. is an important opportunistic pathogen responsible for increasing number of nosocomial infections. The majority of infections are of epidemic origin, and treatment has become difficult because many strains are resistant to a wide range of antibiotics. The aim of [...] Read more.
Introduction: Acinetobacter spp. is an important opportunistic pathogen responsible for increasing number of nosocomial infections. The majority of infections are of epidemic origin, and treatment has become difficult because many strains are resistant to a wide range of antibiotics. The aim of this study was to investigate the local infections caused by various species of the genus Acinetobacter, occurring in the hospital wards IGiChP in periods of increased prevalence: August 2007 and February and March 2008. Material and methods: Twenty three strains of Acinetobacter spp. were isolated from 19 patients residing in the same period and the same hospital ward (2007–2013 strains from 11 patients, 2008–2010 strains from 8 patients). Acinetobacter isolates obtained from these patients were characterized by phenotypic methods and genotypically by arbitrarily primed PCR (AP-PCR). Results: All strains of Acinetobacter (n = 23) were multi-drug resistant. Used AP-PCR method showed 10 genotypes among the all strains. Acinetobacter spp. strains cultivated in 2007 and 2008 belonged to one genotype, came from patients hospitalized on the same wards, which confirms the transmission of infection in the patientís residence. Conclusions: The same genotype Acinetobacter baumannii strains isolated from two patients in 2007, and two patients in 2008, showed the presence of bacteria in the hospital environment. In the present study, we also established the usefulness of AP-PCR in molecular epidemiological investigations.
Full article
39 KiB  
Editorial
Recommendations on Systemic Treatment of Non-Small Cell Lung Cancer and Malignant Pleural Mesothelioma
by Maciej Krzakowski
Adv. Respir. Med. 2010, 78(6), 384-385; https://doi.org/10.5603/ARM.27693 - 29 Oct 2010
Viewed by 239
Abstract
Lung cancer causes about 1.2 million deathsworldwide annually [...] Full article
71 KiB  
Editorial
The New Recommendations of the 7th Edition of the TNM Classification for Lung Cancer in Pathologic Assessment (pTNM)
by Renata Langfort
Adv. Respir. Med. 2010, 78(6), 379-383; https://doi.org/10.5603/ARM.27692 - 29 Oct 2010
Cited by 1 | Viewed by 224
Abstract
The paper entitled “Nowa klasyfikacja TNMw raku pluca” (The new TNM classification for lungcancer) by Anna Wrona and Jacek Jassem [...] Full article
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