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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.

Adv. Respir. Med., Volume 78, Issue 5 (August 2010) – 7 articles , Pages 315-378

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178 KiB  
Case Report
Gastric Sarcoidosis—A Case Report
by Dariusz Ziora, Barbara Trzepióra and Jerzy Kozielski
Adv. Respir. Med. 2010, 78(5), 374-378; https://doi.org/10.5603/ARM.27712 - 10 Aug 2010
Cited by 2 | Viewed by 225
Abstract
Gastrointestinal sarcoidosis is very rare manifestation of the illness. This article presents patient who had been diagnosed for several months because of abdominal pain, vomiting and significant weight loss. Numerous gastric endoscopy examina- tions showed the difficult healing ulcers in the stomach, progressive [...] Read more.
Gastrointestinal sarcoidosis is very rare manifestation of the illness. This article presents patient who had been diagnosed for several months because of abdominal pain, vomiting and significant weight loss. Numerous gastric endoscopy examina- tions showed the difficult healing ulcers in the stomach, progressive thickening of the mucosal folds with narrowing of the lumen, lack of peristalsis and the rigidity of the walls. Histological examination of the specimen of the ventricular mucosa revealed chronic inflammation, as well as suspicion of tumor infiltration. Finally gastric sarcoidosis has been diagnosed on the basis of CT with double contrast, and histopathological examination of biopsis of stomach collected during laparotomy. Full article
352 KiB  
Case Report
Recurrence of Endobronchial Lipoma
by Lucyna Opoka, Katarzyna Lewandowska, Renata Langfort and Piotr Rudziński
Adv. Respir. Med. 2010, 78(5), 369-373; https://doi.org/10.5603/ARM.27711 - 10 Aug 2010
Viewed by 201
Abstract
Benign tumours of the lung and endobronchial tree are uncommon. Endobronchial lipomas are extremely rare, with an incidence ranging from 0.1 to 0.5% of all lung tumours. Endobronchial lipomas originate from fat cells located in the peribronchial (and occasionally the submucosal) tissue of [...] Read more.
Benign tumours of the lung and endobronchial tree are uncommon. Endobronchial lipomas are extremely rare, with an incidence ranging from 0.1 to 0.5% of all lung tumours. Endobronchial lipomas originate from fat cells located in the peribronchial (and occasionally the submucosal) tissue of the main bronchi. This paper presents the case of a patient in whom, four years after transbronchial resection of an endobronchial lipoma, recurrence of the lesion in the same lung was confirmed. The diagnosis was made on the basis of a CT scan, which detected lesions with previously identified morphology. Full article
112 KiB  
Article
The Comparison between Two Methods for Typing of Nontuberculous Mycobacteria: High Pressure Liquid Chromatography and Molecular Assay Genotype Mycobacterium CM/AS
by Aleksandra Safianowska, Renata Walkiewicz, Patrycja Nejman-Gryz, Ryszarda Chazan and Hanna Grubek-Jaworska
Adv. Respir. Med. 2010, 78(5), 363-368; https://doi.org/10.5603/ARM.27710 - 10 Aug 2010
Viewed by 498
Abstract
Introduction: The GenoType Mycobacterium CM and the GenoType Mycobacterium AS (HAIN Lifescience, Germany) were evaluated for the ability to differentiate mycobacterial species of clinical isolates. Serial use of the both assays is aimed to identify 38 different molecular patterns, of which 24 patterns [...] Read more.
Introduction: The GenoType Mycobacterium CM and the GenoType Mycobacterium AS (HAIN Lifescience, Germany) were evaluated for the ability to differentiate mycobacterial species of clinical isolates. Serial use of the both assays is aimed to identify 38 different molecular patterns, of which 24 patterns can be assigned to single species, 10 patterns are allocated to two or more Mycobacterium species, and 4 patterns correspond to Mycobacterium species and gram-positive bacteria with a high G + C content. The analysis of mycolic acids by high pressure liquid chromatography (HPLC) was the reference method. Materials and methods: A set of 127 nontuberculous mycobacterial isolates on Loewenstein-Jensen media, derived from different patients between 1999 and 2007, was analyzed. The strains were primary classified by HPLC following the diagnostic procedure, and retyped by GenoType Mycobacterium CM/AS. Results: In total, results obtained by both methods were interpretable for 113 strains. Concordant results were obtained for 105 (93%) mycobacterial strains. One out of 8 incorcondantly classified strains, which was classified as M. abscessus/M. chelonae by HPLC, displayed a pattern of M. tuberculosis complex by a molecular method. Eleven clinical strains were differentiated only by one of used methods, either by HPLC (6 strains) or by GenoType CM/AS (5 strains). Three strains were not classified at all. Conclusions: Our results show that the GenoType Mycobacterium CM/AS system represents a useful tool to identify mycobacterial clinical isolates. The molecular system is as rapid and reliable as the HPLC, but much easier to perform and more friendly for the environment. Full article
141 KiB  
Article
Markers of Fibrosis and Inflammation in Exhaled Breath Condensate (EBC) and Bronchoalveolar Lavage Fluid (BALF) of Patients with Pulmonary Sarcoidosis: A Pilot Study
by Anna Kowalska, Elżbieta Puścińska, Justyna Czerniawska, Anna Goljan-Geremek, Monika Czystowska, Adriana Roży, Joanna Chorostowska-Wynimko and Dorota Górecka
Adv. Respir. Med. 2010, 78(5), 356-362; https://doi.org/10.5603/ARM.27709 - 10 Aug 2010
Cited by 3 | Viewed by 238
Abstract
Introduction: Sarcoidosis is a disease of unknown aetiology. Little is known of the predictive factors of fibrosis. It has been suggested that PAI-1, uPA, TGF-β1, VEGF, IL-8, TNF-α influence this process. The aim of the study was to assess airway [...] Read more.
Introduction: Sarcoidosis is a disease of unknown aetiology. Little is known of the predictive factors of fibrosis. It has been suggested that PAI-1, uPA, TGF-β1, VEGF, IL-8, TNF-α influence this process. The aim of the study was to assess airway inflammatory and fibrosis markers in EBC in sarcoidosis and the effects of fibreoptic bronchoscopy (FOB), bronchoalveolar lavage fluid (BALF), transbronchial lung biopsy (TBLB) and bronchial mu- cosa membrane biopsy on their production in the airways. Material and methods: The study group consisted of 11 patients (five women, six men, mean age 40 ± 9 yrs, mean ± SD) with sarcoidosis stage I–III. PAI-1 (ng/mL), uPA (ng/mL), TGF-β1 (pg/mL), VEGF (pg/mL), IL-8 (pg/mL), TNF-α (pg/mL) levels were measured in BALF and EBC collected before, and 48 h after, FOB. Results: No significant changes in EBC levels of VEGF, PAI-1, TGF-β1, TNF-α (respectively: 8.02 ± 4.97 pg/mL; 1.1 ± 1.2 ng/mL; 2909.7 ± 206.6 pg/mL; 10.7 ± 19.9 pg/mL) after FOB were observed when compared to baseline. In contrast, IL-8 concentration in EBC (pg/mL) decreased after FOB (0.073 ± 0.13 vs. 0.061 ± 0.1, p = 0.006) and was significantly lower than in BALF (BALF 0.95 ± 0.62, p < 0.05). Also, the mean level of VEGF was higher in BALF than in EBC both pre- and post- FOB (BALF 66.38 ± 36.95, EBC pre-FOB 6.75 ± 3.67 and EBC post-FOB 8.02 ± 4.97). A significant relationship between TNF-a in post-FOB EBC and BALF was also shown (β = 0.63, p = 0.04). Conclusions: FOB does not significantly affect levels of airway inflammation and fibrosis markers present in EBC before and after FOB; they were also comparable to the concentrations marked by BALF. The lack of correlation between marker levels in EBC and BALF indicates that these methods are not equivalent. Due to the possibility of repetition, and the less invasive, simpler method of the EBC test, it would seem reasonable to continue this research on a larger number of patients. Full article
259 KiB  
Guidelines
Zasady postępowania diagnostycznego i opieki nad chorymi z wrodzonym niedoborem alfa-1 antytrypsyny
by Joanna Chorostowska-Wynimko, Ewa Niżankowska-Mogilnicka, Agnieszka Bakuła, Dorota Górecka, Marek Kulus, Paweł Kuca, Kazimierz Roszkowski-Śliż, Marek Sanak, Piotr Socha and Paweł Śliwiński
Adv. Respir. Med. 2010, 78(5), 348-355; https://doi.org/10.5603/ARM.27714 - 10 Aug 2010
Viewed by 231
Abstract
Niedobór alfa-1 antytrypsyny (AAT, alpha-1 antitrypsin) jest najczęstszą uwarunkowaną genetycznie chorobą w populacji osób dorosłych rasy kaukaskiej [...] Full article
435 KiB  
Guidelines
Zalecenia Polskiego Towarzystwa Chorób Płuc rozpoznawania i leczenia przewlekłej obturacyjnej choroby płuc (POChP)
by Władysław Pierzchała, Adam Barczyk, Dorota Górecka, Paweł Śliwiński and Jan Zieliński
Adv. Respir. Med. 2010, 78(5), 318-347; https://doi.org/10.5603/ARM.27713 - 10 Aug 2010
Cited by 1 | Viewed by 287
Abstract
Pierwsze krajowe Zalecenia Postępowania w przewlekłej obturacyjnej chorobie płuc (POChP) powstały w 1998 roku z inicjatywy prof. Jana Zielińskigo i prof. Józefa Małolepszego oraz dr. Władysława Pierzchały przy wsparciu organizacyjnym firmy Boehringer Ingelheim i pracy twórczej zespołu autorów Polskiego Towarzystwa Ftyzjopneumonologicznego [...] Full article
392 KiB  
Editorial
Polskie Towarzystwo Chorób Płuc w latach 2006–2010
by Władysław Pierzchała
Adv. Respir. Med. 2010, 78(5), 315-317; https://doi.org/10.5603/ARM.27708 - 10 Aug 2010
Viewed by 201
Abstract
Szanowni Koleżanki i Koledzy [...] Full article
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